MM Kit is indicated for early Menstrual Regulation (MR)/termination of pregnancy up to 9 weeks (63 days) of gestation.
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Mifepristone is a medication used to induce abortion in the early stages of pregnancy. It is used until week ten of pregnancy (up to 70 days after the first day of your last menstrual period). Mifepristone inhibits the production of a natural substance (progesterone), which is required for the continuation of your pregnancy. It is typically used in conjunction with another medication known as misoprostol. If you have a rare abnormal pregnancy that is outside the womb, you should not use mifepristone (ectopic pregnancy). In this case, it will not result in an abortion. It has the potential to rupture an ectopic pregnancy, resulting in severe bleeding.
Composition of mifepristone & Misoprostol (MM KIT):
It is unsafe to consume alcohol with MM-Kit.
MM-Kit is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects on the developing baby.
MM-Kit is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
MM-Kit may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
There is limited information available on the use of MM-Kit in patients with kidney disease. Please consult your doctor.
MM-Kit is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of MM-Kit may not be needed in these patients. Please consult your doctor.
Mifton (Mifepristone): Mifepristone is a synthetic steroid with an anti-progestational activity that results from competitive interaction with progesterone at progesterone-receptor sites. Based on studies with various oral doses in several animals, species the compound inhibits the activity of endogenous or exogenous progesterone and the Menstrual Regulation (MR) results. During pregnancy, the compound sensitizes the myometrium to the contraction-inducing activity of prostaglandins.
Misotol (Misoprostol): Misoprostol is a synthetic analog of prostaglandin E1. It causes myometrial contraction by interacting with specific receptors on myometrial cells. This interaction results in a change in calcium concentration, thereby initiating muscle contraction. By interacting with prostaglandin receptors, Misoprostol causes the cervix to soften and the uterus to contract, resulting in the expulsion of the uterine contents.
Only qualified medical professionals who can assess an embryo's gestational age and diagnose ectopic pregnancies can prescribe the MM Kit. In addition, qualified medical professionals must be able to provide surgical intervention/MVA (Manual Vacuum Aspiration) in cases of incomplete abortion or severe bleeding, or have plans in place to provide such care through others, and be able to ensure patient access to medical facilities equipped to provide blood transfusions and resuscitation, if necessary.
Day 1 (First visit): Mifepristone administration
Day 2 (Second visit): Misoprostol administration
Day 10 to 14 (Third visit): post-treatment examination
Mifton (Mifepristone): The treatment procedure is designed to induce vaginal bleeding and uterine cramping necessary for Menstrual Regulation (MR).
Misotol (Misoprostol): Gastro-intestinal side-effects like
Pain due to uterine contractions, severe vaginal bleeding, shock, pelvic pain, and uterine rupture (requiring surgical repair, hysterectomy, and/or salpingo-oophorectomy).
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. MM-Kit is to be taken with food.
MM-Kit is a combination of two medicines: Mifepristone and Misoprostol, which causes abortion. Mifepristone blocks the effects of progesterone, a natural female hormone that is needed for the pregnancy to sustain. Without this hormone, the lining of the uterus (womb) breaks down as it does during a menstrual period and stops the growth of the pregnancy. Mifepristone increases contractions of the uterus to cause abortion.
Use in Patients
Use in Patients
Mifton (Mifepristone): No serious adverse reactions were reported in tolerance studies in healthy nonpregnant female and healthy male subjects where Mifepristone was administered in single doses greater than threefold of 600mg for Menstrual Regulation (MR). If a patient ingests a massive overdose, she should be observed closely for signs of adrenal failure.
Misotol (Misoprostol): Clinical signs that may indicate an overdose are a sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea, fever, palpitations, hypotension, or bradycardia. Symptoms should be treated with supportive therapy. However, because Misoprostol is metabolized like a fatty acid, it is unlikely that dialysis would be an appropriate treatment for overdosage.
Pregnancy:
Mifton (Mifepristone):
Lactation:
Mifton (Mifepristone):
Misotol (Misoprostol):
Mifton (Mifepristone): Although specific drug or food interactions with Mifepristone have not been studied, on the basis of this drug's metabolism by CYP 3A4, it is possible that Ketoconazole, Itraconazole, Erythromycin, and grapefruit juice may inhibit its metabolism (increasing serum levels of mifepristone).
Misotol® (Misoprostol): Misoprostol has not been shown to interfere with the beneficial effects of aspirin on signs and symptoms of rheumatoid arthritis. Misoprostol does not exert clinically significant effects on the absorption, blood levels, and antiplatelet effects of therapeutic doses of aspirin.
Administration of Mifepristone is contraindicated in patients with any one of the following conditions: History of allergy or known hypersensitivity to Mifepristone, Misoprostol or another prostaglandin, confirmed or suspected ectopic pregnancy or undiagnosed adnexal mass (the treatment procedure will not be effective to terminate an ectopic pregnancy), IUD in place, chronic adrenal failure, hemorrhagic disorders or concurrent anticoagulant therapy, inherited porphyria, If a patient does not have adequate access to medical facilities equipped to provide emergency treatment of incomplete process, blood transfusions, and emergency resuscitation during the period from the first visit until discharged by the administering physician.
Discard any unused medicine properly. Do not flush it in the toilet or throw it into the drain.