MM Kit | 200mg+200mcg | Uses, Dosage | Home Delivery | ePharma
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MM Kit is indicated for early Menstrual Regulation (MR)/termination of pregnancy up to 9 weeks (63 days) of gestation. 


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Description:

Mifepristone is a medication used to induce abortion in the early stages of pregnancy. It is used until week ten of pregnancy (up to 70 days after the first day of your last menstrual period). Mifepristone inhibits the production of a natural substance (progesterone), which is required for the continuation of your pregnancy. It is typically used in conjunction with another medication known as misoprostol. If you have a rare abnormal pregnancy that is outside the womb, you should not use mifepristone (ectopic pregnancy). In this case, it will not result in an abortion. It has the potential to rupture an ectopic pregnancy, resulting in severe bleeding.

Composition of mifepristone & Misoprostol (MM KIT):

  • Each box contains 2 blister strips.
  • Mifton strip: Each strip contains 1 tablet of Mifepristone INN 200 mg.
  • Misotol strip: Each strip contains 4 tablets of Misoprostol USP 200 microgram each.

Safety Advices


Alcohol
UNSAFE

It is unsafe to consume alcohol with MM-Kit.


Pregnancy
UNSAFE

MM-Kit is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects on the developing baby.


Breastfeeding
UNSAFE

MM-Kit is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.


Driving
UNSAFE

MM-Kit may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.


Liver
CONSULT YOUR DOCTOR

There is limited information available on the use of MM-Kit in patients with kidney disease. Please consult your doctor.


Kidney
SAFE IF PRESCRIBED

MM-Kit is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of MM-Kit may not be needed in these patients. Please consult your doctor.

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Pharmacology

Mifton (Mifepristone): Mifepristone is a synthetic steroid with an anti-progestational activity that results from competitive interaction with progesterone at progesterone-receptor sites. Based on studies with various oral doses in several animals, species the compound inhibits the activity of endogenous or exogenous progesterone and the Menstrual Regulation (MR) results. During pregnancy, the compound sensitizes the myometrium to the contraction-inducing activity of prostaglandins.

Misotol (Misoprostol): Misoprostol is a synthetic analog of prostaglandin E1. It causes myometrial contraction by interacting with specific receptors on myometrial cells. This interaction results in a change in calcium concentration, thereby initiating muscle contraction. By interacting with prostaglandin receptors, Misoprostol causes the cervix to soften and the uterus to contract, resulting in the expulsion of the uterine contents.

Dosage & Administrations of MM Kit:

Only qualified medical professionals who can assess an embryo's gestational age and diagnose ectopic pregnancies can prescribe the MM Kit. In addition, qualified medical professionals must be able to provide surgical intervention/MVA (Manual Vacuum Aspiration) in cases of incomplete abortion or severe bleeding, or have plans in place to provide such care through others, and be able to ensure patient access to medical facilities equipped to provide blood transfusions and resuscitation, if necessary.

Day 1 (First visit): Mifepristone administration

  • One tablet of Mifepristone (200 mg) is taken in a single oral dose under the supervision of a qualified medical professional in a clinic, medical office, or hospital.

Day 2 (Second visit): Misoprostol administration

  • 24-48 hours after ingesting the Mifepristone tablet, the patient takes four 200-microgram tablets(800 micrograms) of Misoprostol buccally or sublingually. Misoprostol tablets can be administered by the patient herself (place two tablets on each side of the cheek & gum or under the tongue). She should wait for 30 minutes.
  • During the period immediately following the administration of Misoprostol, the patient may need medication for cramps or gastrointestinal symptoms. The patient should be given instructions on what to do if significant discomfort, excessive bleeding, or other adverse reactions occur and should be given a phone number to call if she has questions following the administration of Misoprostol.

Day 10 to 14 (Third visit): post-treatment examination

  • Patients must return to the clinic, medical office, or hospital within 10 to 14 days after the administration of mifepristone. This visit is very important to confirm by clinical examination or ultrasonography scan that a complete termination of pregnancy has occurred.
Uses of MM-Kit
  • Medical Abortion
Quick Suggestions:
  • The MM-Kit aids in the termination of a pregnancy.
  • It can cause dizziness and sleepiness when driving or doing anything that requires concentration.
  • It does not affect fertility. To prevent pregnancy, use contraception.
  • Termination of pregnancy
MM KIT Side Effects

Mifton (Mifepristone): The treatment procedure is designed to induce vaginal bleeding and uterine cramping necessary for Menstrual Regulation (MR). 

  • Common side effects: Nausea/Vomiting and Diarrhea.
  • Rare side effects: Pelvic pain, Fainting, Headache, Dizziness, and Asthenia

Misotol (Misoprostol): Gastro-intestinal side-effects like 

  • Diarrhea
  • Abdominal pain
  • Flatulence
  • Dyspepsia
  • Headache
  • Vomiting and constipation
  • Shivering
  • Hyperthermia
  • Dizziness

Pain due to uterine contractions, severe vaginal bleeding, shock, pelvic pain, and uterine rupture (requiring surgical repair, hysterectomy, and/or salpingo-oophorectomy).

How to use MM-Kit

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. MM-Kit is to be taken with food.

How does MM-Kit work?

MM-Kit is a combination of two medicines: Mifepristone and Misoprostol, which causes abortion. Mifepristone blocks the effects of progesterone, a natural female hormone that is needed for the pregnancy to sustain. Without this hormone, the lining of the uterus (womb) breaks down as it does during a menstrual period and stops the growth of the pregnancy. Mifepristone increases contractions of the uterus to cause abortion.

Use in Impairmnet patients:

Use in Patients 

  • With Hepatic Impairment: Misotol® (Misoprostol): Patients with hepatic disease should receive the decreased dose.

Use in Patients 

  • With Renal Impairment: Misotol® (Misoprostol): No routine dosage adjustment is recommended in older patients or patients with renal impairment but the dosage may need to be reduced if the usual dose is not tolerated.
Overdosage of MM KIT:

Mifton (Mifepristone): No serious adverse reactions were reported in tolerance studies in healthy nonpregnant female and healthy male subjects where Mifepristone was administered in single doses greater than threefold of 600mg for Menstrual Regulation (MR). If a patient ingests a massive overdose, she should be observed closely for signs of adrenal failure.

Misotol (Misoprostol): Clinical signs that may indicate an overdose are a sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea, fever, palpitations, hypotension, or bradycardia. Symptoms should be treated with supportive therapy. However, because Misoprostol is metabolized like a fatty acid, it is unlikely that dialysis would be an appropriate treatment for overdosage.

Use of MM Kit in Pregnancy and Lactation:

Pregnancy:

Mifton (Mifepristone): 

  • It is indicated for Menstrual Regulation (MR) (through 63 days of pregnancy) and has no other approved indication for use during pregnancy. Patients who have an ongoing pregnancy at the last visit have a risk of fetal malformation resulting from the treatment. Surgical termination is recommended to manage Menstrual Regulation (MR) treatment failures.

Lactation:

Mifton (Mifepristone):

  • It is not known whether Mifepristone is excreted through human milk. Many hormones with a similar chemical structure, however, are excreted in breast milk. Since the effects of Mifepristone on infants are unknown, breastfeeding women should consult with their doctor to decide if they should discard their breastmilk for a few days following the administration of the medications.

Misotol (Misoprostol): 

  • Although it is not known whether Misoprostol or Misoprostol is excreted through human milk, Misoprostol should not be administered to nursing mothers because the potential excretion of misoprostol acid could cause diarrhea in nursing infants.
MM KIT Drug Interaction

Mifton (Mifepristone): Although specific drug or food interactions with Mifepristone have not been studied, on the basis of this drug's metabolism by CYP 3A4, it is possible that Ketoconazole, Itraconazole, Erythromycin, and grapefruit juice may inhibit its metabolism (increasing serum levels of mifepristone).

Misotol® (Misoprostol): Misoprostol has not been shown to interfere with the beneficial effects of aspirin on signs and symptoms of rheumatoid arthritis. Misoprostol does not exert clinically significant effects on the absorption, blood levels, and antiplatelet effects of therapeutic doses of aspirin.

Contraindication

Administration of Mifepristone is contraindicated in patients with any one of the following conditions: History of allergy or known hypersensitivity to Mifepristone, Misoprostol or another prostaglandin, confirmed or suspected ectopic pregnancy or undiagnosed adnexal mass (the treatment procedure will not be effective to terminate an ectopic pregnancy), IUD in place, chronic adrenal failure, hemorrhagic disorders or concurrent anticoagulant therapy, inherited porphyria, If a patient does not have adequate access to medical facilities equipped to provide emergency treatment of incomplete process, blood transfusions, and emergency resuscitation during the period from the first visit until discharged by the administering physician.

Precaution and Warnings:
  • The patient should not give a combination of Mifepristone & Misoprostol to anyone else.
  • The combination of Mifepristone & Misoprostol has been prescribed for the patient's specific condition, it may not be the correct treatment for another person, and may be dangerous to the other person if she is or were to become pregnant. Any Intra Uterine Device [IUD] should be removed before treatment with Mifepristone begins.
  • Menstrual Regulation (MR) by surgery is recommended in cases when a combination of Mifepristone & Misoprostol fails to cause Menstrual Regulation (MR).
  • Patients who have an ongoing pregnancy at the last visit have a risk of fetal malformation resulting from the treatment.
  • Surgical termination/MVA is recommended to manage Menstrual Regulation (MR)/ termination of pregnancy failures.
MM KIT Storage
  • Store the MM KIT at room temperature in a clean and dry place, protected from moisture, sunlight, and heat.
  • Keep the medicine away from children and pets.
Disposal of MM KIT

Discard any unused medicine properly. Do not flush it in the toilet or throw it into the drain.

Frequently Asked Questions (FAQ)

Mifepristone and Misoprostol are up to 95-98% effective in ending a pregnancy when used together, depending on how far along the pregnancy is.

Mifepristone is usually taken orally in a clinic or doctor's office, while Misoprostol is usually taken at home 24-48 hours later. Your healthcare provider will provide detailed instructions on how to take both medications.

The abortion process typically takes about one to two weeks from start to finish, depending on how far along the pregnancy is.

Yes, MM Kit is usually taken at home, but it's important to follow your healthcare provider's instructions and have someone with you during the process.

Like all medical procedures, there are risks associated with a medical abortion, including infection, heavy bleeding, and incomplete abortion. However, serious complications are rare.

Yes, it is possible to get pregnant again after a medical abortion. However, it's recommended to wait at least two weeks before having sex to reduce the risk of infection

Your healthcare provider will monitor your symptoms and may perform a follow-up exam or ultrasound to confirm that the abortion was successful.

The legality of Mifepristone and Misoprostol varies by country and region. It's important to check local laws and regulations before seeking a medical abortion.

Mifepristone and Misoprostol are two medications used together in a medical abortion, also known as an abortion pill. Mifepristone is taken first to block the hormone progesterone, which is necessary for pregnancy. Misoprostol is taken a few days later to induce contractions and expel the pregnancy.
Ratings & Reviews

5
Verified Buyer
11 Mar, 2023
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Rakib
5
Verified Buyer
01 Jan, 2024

Hi, there!



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