Generic name: Glyceryl Trinitrate (Nitroglycerine) 400mcg
Company Name: Healthcare Pharmaceuticals Limited
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Indications
Nitroglycerin sublingual spray is used to treat angina pectoris brought on by coronary artery disease for either prophylaxis or immediate relief.
Pharmacology
The primary pharmacological action of nitroglycerin is the unwinding of vascular smooth muscle, which has more obvious effects on veins and fringe supply routes while also having a vasodilator effect on both. Enlargement of the post-capillary vessels, including large veins, promotes blood pooling at the heart's periphery and reduces venous return, which lowers the weight of the heart's cleared-out ventricular end-diastole (pre-load). Reduced systemic vascular resistance and blood vessel weight are caused by artery unwinding (after-load).
Administration & Dosage
Interaction
When alcohol is combined with Nitroglycerin, it can cause severe hypotension and collapse. Oral Nitroglycerin may improve dihydroergotamine bioavailability. When calcium channel blockers, phenothiazines, and tricyclic antidepressants are taken together, orthostatic hypotension can occur.
Contraindications
Hypersensitivity to nitrates or any other formulation component. Hypertrophic obstructive cardiomyopathy causes hypotension, hypovolemia, severe anemia, cerebral haemorrhage and brain trauma, mitral stenosis, and angina. Phosphodiesterase inhibitors for the treatment of erectile dysfunction are given at the same time.
Side Effect
Headache, facial flushing, dizziness, nausea, vomiting, feelings of weakness, postural hypotension, and reflex tachycardia are all possible nitrate side effects.
Pregnancy & Lactation
Pregnancy Classification C. In pregnant women, there are no adequate and well-controlled studies. Nitroglycerin should only be administered to pregnant women if absolutely necessary. Whether nitroglycerin is excreted in human milk is unknown. Because many drugs are excreted in human milk, care should be taken when administering Nitroglycerin spray to a nursing mother.
Precautions & Warnings
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.