Suspension. Manufacturer/Distributor: Orion pharma. Generic Name: Azithromycin 35 ml PFS
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Azalid 35 ml Powder For Solution is used to treat infections in the lower respiratory tract, such as bronchitis and pneumonia, as well as infections in the upper respiratory tract, such as sinusitis and pharyngitis/tonsillitis, otitis media, and skin and soft tissue infections. Azalid 35 ml Powder For Solution is used to treat non-gonococcal urethritis and cervicitis caused by Chlamydia trachomatis in both men and women with sexually transmitted infections.
Azithromycin is stable to acid, so it can be taken orally without protecting stomach acid. Easily absorbed; greater absorption on an empty stomach. For oral dosage forms, the time for adults to reach maximum concentration is 2.1 to 3.2 hours. Due to the high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, high concentrations of azithromycin are released. The concentration of azithromycin in tissues can be 50 times higher than in plasma. This is due to ion trapping and high fat solubility. The half-life of
Azithromycin allows a single high-dose administration, but it can still maintain the antibacterial level in the infected tissue for several days. After a single administration of 500 mg, the plasma concentration of azithromycin showed a multiphasic decline, the average apparent plasma clearance rate was 630 ml/min, and the terminal elimination half-life was 68 hours. The extended terminal half-life is believed to be due to the massive absorption and subsequent release of the drug from the tissue. The bile excretion of azithromycin (mainly unchanged) is the main route of elimination. Over the course of a week, approximately 6% of the administered dose appeared as the parent drug in the urine.
Microbiology: Azithromycin works by binding to the 50S ribosomal subunit of susceptible microorganisms, which interferes with the synthesis of microbial proteins. Nucleic acid synthesis is not affected. In vitro and in clinical infections, azithromycin has been shown to be active against most isolates of the following microorganisms:
Oral-
Adult:
Children:
Azithromycin Injection (For IV Infusion only): The recommended dose of Azithromycin for injection for the treatment of adult patients with community-acquired pneumonia due to the indicated organisms is:
Reconstitution procedure of suspension-
Azithromycin should be taken at least 1 hour before or 2 hours after meal.
In the presence of food or an antacid, azithromycin absorption is reduced. Because of the risk of ergotism from Azithromycin's interaction with the cytochrome P-450 system, it should be avoided in patients receiving ergot alkaloids. Because macrolides raise digoxin and cyclosporin plasma concentrations, caution should be used while taking them together. Azithromycin has not been found to interact with Warfarin, Theophylline, Carbamazepine, Methylprednisolone, or Cimetidine.
Patients who are hypersensitive to Azalid 35 ml Powder For Solution or any other macrolide antibiotic should avoid taking it. Ergot derivatives and azithromycin should not be taken together. Patients with hepatic disorders should avoid Azalid 35 ml Powder For Solution.
Azalid 35 ml Powder For Solution is a well-tolerated antibiotic with few adverse effects. Nausea, vomiting, abdominal discomfort (pain/cramps), flatulence, diarrhea, headache, dizziness, and skin rashes are among the side effects, which are reversible as the medication is stopped.
Azithromycin falls into the B pregnancy category. Azithromycin has been shown in animal reproductive tests to cause no harm to the fetus. In pregnant women, there are no sufficient and well-controlled trials. Because animal reproduction studies do not always reflect human response, Azalid 35 ml Powder For Solution should only be administered during pregnancy if there are no other options. Azithromycin is not known to be secreted in breast milk. As a result, when Azithromycin is given to a nursing woman, vigilance should be observed.
As with any antibiotic, observation for signs of superinfection with non-susceptible organisms, including fungi, is recommended. No dose adjustment is needed in patients with renal impairment.
Macrolides
Keep in a dry place away from light and heat. Keep out of the reach of children.
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