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Azin 500mg Tablet 1 Strip
Azithromycin is acid-stable and well-absorbed when taken orally, with enhanced absorption on an empty stomach. Peak plasma levels occur within 2.1–3.2 hours. It accumulates significantly in phagocytes and is delivered directly to infection sites, where it is released during phagocytosis. Tissue concentrations can be over 50 times greater than plasma levels due to lipid solubility and ion trapping.
The drug has a long half-life, allowing for once-daily or short-course dosing. After a single 500 mg dose, azithromycin exhibits a terminal half-life of about 68 hours. It is mainly eliminated via bile in an unchanged form, with only 6% excreted unchanged in urine over one week.
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✅ Description:
Azin is prescribed for infections caused by susceptible organisms. These include:
- Lower respiratory tract infections (e.g., bronchitis, pneumonia)
- Upper respiratory tract infections (e.g., sinusitis, pharyngitis, tonsillitis)
- Otitis media
- Skin and soft tissue infections
- Sexually transmitted infections, such as non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis
To ensure effectiveness, complete the entire prescribed course of Azin 500 mg, even if symptoms improve early. Premature discontinuation may result in relapse and resistance.
Common side effects include diarrhea, which usually resolves after treatment ends. Consult a doctor if it persists or if there’s blood in stool. Discontinue use and seek immediate medical help if you experience symptoms like rash, facial or throat swelling, or breathing difficulty.
Take Azin 500 mg orally 1 hour before or 2 hours after meals. Avoid taking antacids within 2 hours before or after taking this medicine.
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✔️ Side Effects
Generally well-tolerated. Mild to moderate GI disturbances are common:
- Nausea, abdominal pain, vomiting, flatulence, diarrhea
- Other possible reactions:
- Skin rashes, photosensitivity
- Rare but serious hypersensitivity reactions
- Reversible elevation of liver enzymes
Rare: cholestatic jaundice, hearing disturbances (with high or prolonged doses), neutrophil count reduction
✔️ Mechanism of Action / Microbiology
Azithromycin binds to the 50S ribosomal subunit of bacteria, inhibiting protein synthesis without affecting nucleic acid synthesis. It is effective against:
Gram-positive bacteria:
- Staphylococcus aureus
- Streptococcus pneumoniae
- Streptococcus pyogenes
- Streptococcus agalactiae
- Viridans group streptococci
- Groups C, F, and G streptococci
Gram-negative bacteria:
- Haemophilus influenzae
- Haemophilus ducreyi
- Moraxella catarrhalis
- Neisseria gonorrhoeae
- Bordetella pertussis
- Legionella pneumophila
Others:
- Chlamydia pneumoniae
- Chlamydia trachomatis
- Mycoplasma pneumoniae
Anaerobes:
- Peptostreptococcus species
- Prevotella bivia
Its activity is unaffected by beta-lactamase enzymes.
✔️ Dosage & Administration
Adults (Oral):
- 500 mg once daily for 3 days, or
- 500 mg on day 1, followed by 250 mg daily on days 2–5
- For STIs due to Chlamydia trachomatis: 1 g as a single dose or 500 mg on day 1, followed by 250 mg daily for 2 days
Children (Oral):
- 10 mg/kg daily for 3 days (for children over 6 months)
- 15–25 kg: 200 mg/day
- 26–35 kg: 300 mg/day
- 36–45 kg: 400 mg/day
- Typhoid fever: 500 mg daily for 7–10 days
- Renal impairment: No adjustment needed for CrCl >40 ml/min; use cautiously in severe impairment.
- Hepatic impairment: Avoid due to primary hepatic elimination.
- Driving/operating machinery: No known impairment effects.
✔️ Overdose Effects:
No specific data available. Symptoms may include:
- Severe nausea, vomiting, diarrhea
- Hearing loss
- Management involves gastric lavage and supportive care.
✔️ Drug Interactions
- Antacids: Avoid taking within 2 hours of Azin.
- Cyclosporine: Monitor blood levels closely if co-administered.
- Digoxin: Monitor levels, as metabolism may be affected.
- Ergot derivatives: Avoid combination due to risk of ergotism.
- Theophylline/Carbamazepine/Methylprednisolone/Warfarin: No significant interaction, but monitoring is advisable.
- Terfenadine: No QT prolongation has been reported for concurrent use.
✔️ Contraindications
- Hypersensitivity to azithromycin or other macrolides
- Co-use with ergot derivatives
- Patients with liver disease
✔️ Use in Pregnancy & Lactation
- Pregnancy Category B: No fetal harm in animal studies, but human data is limited. Use only if necessary.
- Breastfeeding: Unknown if excreted in milk; use with caution.
✔️ Precautions
- Watch for signs of allergic reactions, especially during initial doses.
- Recurrent reactions may require extended observation and management.
- Use cautiously in patients with moderate to severe renal impairment.
✔️ Storage
Store in a cool, dry place, protected from heat and light. Keep out of children's reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
