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Bestron 0.45mg+20mg Tablet
Conjugated Estrogen+Bazedoxifene || 0.45mg+20mg
- Treatment of moderate to severe vasomotor symptoms due to menopause
- Prevention of osteoporosis in postmenopausal women
This medication works by modulating estrogen receptor activity. Conjugated estrogens act on estrogen receptors to relieve symptoms of estrogen deficiency, while bazedoxifene selectively blocks estrogen’s effects on the uterus, offering endometrial protection.
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✅ Description:
Bestron is a combination therapy comprising conjugated estrogens and bazedoxifene (a selective estrogen receptor modulator or SERM). It is prescribed for women with an intact uterus to manage moderate to severe menopausal symptoms (such as hot flashes and vaginal dryness) and to prevent postmenopausal osteoporosis. The estrogen component alleviates menopausal symptoms, while bazedoxifene helps maintain bone density and lowers the risk of estrogen-induced endometrial cancer.
✔️ Dosage & Administration
Adult Dose: One tablet orally once daily, with or without food.
Pediatric Use: Not indicated for use in children.
Renal Impairment: Use with caution; dose adjustment may be necessary. Consult a physician.
✔️ Side Effects
- High blood pressure
- Thromboembolic events
- Liver or thyroid dysfunction
- Breast lumps or abnormal bleeding
- Muscle cramps, fatigue
- Gastrointestinal upset (nausea, diarrhea)
- Throat irritation, confusion
✔️ Interaction
No direct interaction studies are available
Estrogens are metabolized by CYP3A4; use with CYP3A4 inhibitors may increase estrogen levels, raising the risk of endometrial hyperplasia
✔️ Contraindications
- Undiagnosed vaginal bleeding
- Current or history of breast or estrogen-dependent cancer
- Active or past thromboembolic events (e.g., DVT, PE)
- Active arterial thromboembolic disease
- Severe liver dysfunction
- Known hypersensitivity to any components
- Known thrombophilic disorders
✔️ Precautions
- Not recommended for cardiovascular disease or dementia prevention
- Increased risk of endometrial cancer with unopposed estrogen in women with a uterus
- Regular monitoring is advised during prolonged use
✔️ Pregnancy & Lactation
Not for use during pregnancy or breastfeeding
May reduce breast milk quality and production
✔️ Storage:
- Store below 30°C
- Protect from light and moisture
- Keep out of reach of children
- Use within 60 days of opening the foil pouch
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
