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Diclomol 1% Gel 20g Tube
Diclomol contains Diclofenac Sodium, a powerful non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, anti-rheumatic, and antipyretic properties. It also has mild uricosuric effects.
Diclofenac works by inhibiting prostaglandin biosynthesis, which plays a key role in pain, inflammation, and fever. When taken with or after food, it is rapidly and completely absorbed through the gastrointestinal tract, reaching peak plasma concentration within approximately 2 hours. At therapeutic levels, 99.7% of the drug binds to plasma proteins. It is metabolized in the liver and undergoes first-pass metabolism.
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✅ Description:
- Rheumatology: Used for treating inflammatory and degenerative rheumatic conditions such as chronic involutive polyarthritis, ankylosing spondylitis, osteoarthritis, spondylarthrosis, acute gout, and peri-articular rheumatic disorders.
- Surgery and Traumatology: Effective for managing pain and inflammation in cases of sprains, bruises, dislocations, fractures, soft tissue injuries, and post-surgical recovery.
- Obstetrics and Gynecology: Recommended for conditions like primary dysmenorrhea, episiotomy, adnexitis, endometritis, parametritis, salpingitis, and mastitis.
- Otorhinolaryngology (ENT): Used as a pre-operative medication to reduce pain, swelling, and inflammation.
- Dentistry: Helps alleviate post-operative and post-traumatic pain, swelling, and inflammation.
- Other Uses: Prescribed for pain relief and inflammation management in patients who have undergone surgery on the urogenital tract, as well as for renal and biliary colic.
Always take this medication under the supervision of a registered physician.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Diclofenac Gel (Topical Use):
- Adults: Apply 2–4 g of gel on the affected area 3–4 times daily. Rub in lightly. Can be used alongside oral diclofenac for additional relief.
✔️ Drug Interactions
- Lithium & Digoxin: May elevate plasma concentrations of these drugs.
- Anticoagulants: May slightly increase the risk of bleeding, though studies show no major impact on anticoagulant effects.
- Oral Antidiabetic Agents: No significant impact on blood sugar control when taken with diclofenac.
- Cyclosporin: Co-administration may increase nephrotoxicity.
- Methotrexate: Severe toxicity may occur if taken within 24 hours of NSAIDs.
- Quinolone Antibiotics: Increased risk of seizures when combined with NSAIDs.
- Other NSAIDs & Steroids: May increase adverse effects when used together. With aspirin, both drugs may have reduced plasma levels, though clinical significance is unclear.
✔️ Diclomol is generally well-tolerated, with mild and temporary side effects. Some possible reactions include:
- Gastrointestinal issues: Mild epigastric pain, nausea, diarrhea, or bloating.
- Neurological effects: Dizziness or headache.
- Skin reactions: Rash, eczema, and redness (especially with Diclofenac Gel).
- Peripheral edema: Mild swelling in some cases.
✔️ Diclomol should not be used in patients who:
- Are allergic to diclofenac or any of its ingredients.
- Have a peptic ulcer or gastrointestinal bleeding.
- Have a history of asthma, urticaria, or acute rhinitis triggered by aspirin or other NSAIDs.
- Should not apply Diclofenac Gel under airtight dressings.
✔️ Pregnancy & Lactation
- Diclofenac should only be used during pregnancy if necessary.
- The lowest effective dose is recommended.
- It is not advised in the first trimester due to a lack of clinical data.
- A small amount may pass into breast milk, but no harmful effects have been reported in infants.
✔️ Precautions & Warnings
- Long-term use may increase the risk of peptic ulcers or gastrointestinal bleeding.
- Elderly patients require careful monitoring.
- Diclofenac Gel should not come into contact with the eyes or mucous membranes.
- Wash your hands after applying the gel and do not ingest it.
✔️ Storage:
- Store in a cool, dry place, away from light.
- Keep below 30°C.
- Keep out of children’s reach.
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