Turboclav 250mg Tablet 4pcs

✔️ Uses of Turboclav 250mg Tablet

Turboclav 250 is indicated for the treatment of infections caused by sensitive bacteria, including:

• Pharyngitis/Tonsillitis
• Acute Bacterial Otitis Media
• Acute Bacterial Maxillary Sinusitis
• Lower Respiratory Tract Infections, including pneumonia
• Acute Bacterial Exacerbation of Chronic Bronchitis
• Uncomplicated Skin and Skin-Structure Infections
• Uncomplicated Urinary Tract Infections
• Bone and Joint Infections
• Uncomplicated Gonorrhea
• Early Lyme Disease
• Septicemia
• Meningitis

✔️ How does Turboclav 250mg Tablet work?

Turboclav 250 combines Cefuroxime, which inhibits bacterial cell wall synthesis, and Clavulanic Acid, which inhibits beta-lactamase enzymes that degrade Cefuroxime. This combination extends the antibacterial spectrum of Cefuroxime to include many resistant bacteria.

✔️ Side Effects of Turboclav 250mg Tablet

Common side effects include nausea, vomiting, diarrhea, abdominal discomfort, or pain. Rarely, renal dysfunction, anaphylaxis, angioedema, pruritis, rash, and serum sickness-like urticaria may occur.

✔️ Quick Suggestions:

• Complete the full course of treatment even if you feel better.
• Take with food to avoid an upset stomach.
• Diarrhea may occur; probiotics may help.
• Avoid using leftover medicine for future infections.
• Seek immediate medical help for allergic reactions.

✔️ Indication of Turboclav 250mg Tablet

Turboclav is indicated for the treatment of the following infections:

• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains), or Streptococcus pyogenes.
• Acute Bacterial Maxillary Sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non-beta-lactamase producing strains).
• Lower Respiratory Tract Infections including pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, and E. coli.
• Acute Bacterial Exacerbation of Chronic Bronchitis and Secondary Bacterial Infections of Acute Bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains), or Haemophilus parainfluenzae (beta-lactamase negative strains).
• Uncomplicated Skin and Skin-Structure Infections caused by Staphylococcus aureus (including beta-lactamase producing strains) or Streptococcus pyogenes.
• Uncomplicated Urinary Tract Infections caused by E.coli or Klebsiella pneumoniae.
• Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
• Uncomplicated Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae.
• Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi.
• Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E.coli, Haemophilus influenzae (including ampicillin-resistant strains), and Klebsiella spp.
• Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseria meningitidis, and Staphylococcus aureus (penicillinase and non-penicillinase producing strains).
• Switch Therapy (Injectable to oral).

✔️ Pharmacology

• Cefuroxime: A second-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by interfering with the transpeptidation process, making it effective against a wide range of Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains.
• Clavulanic Acid: A beta-lactamase inhibitor that protects Cefuroxime from degradation by beta-lactamase enzymes, thereby extending its spectrum of activity.

✔️ Dosage & Administration of Turboclav 250mg Tablet

Adolescents and Adults (13 years and older):

• Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
• Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
• Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
• Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
• Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
• Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
• Uncomplicated Gonorrhoea: 1000 mg b.i.d. single dose
• Community-acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
• MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
• Early Lyme disease: 500 mg b.i.d. for 20 days

Pediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
• Acute otitis media: 30 mg/kg/day b.i.d for 10 days
• Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
• Impetigo: 30 mg/kg/day b.i.d for 10 days

Turboclav tablets may be taken without regard to food.

✔️ Interaction

• Probenecid: Concomitant administration increases the area under the serum concentration versus time curve by 50%.
• Gastric Acid-Reducing Drugs: May lower the bioavailability of Cefuroxime.

✔️ Contraindications

• Known allergy to cephalosporins.
• Patients with Pseudomembranous Colitis.

✔️ Pregnancy & Lactation

• Should be avoided in the first trimester if possible. Can be safely used in later pregnancy to treat urinary and other infections.
• Excreted in small quantities into breast milk. The potential for sensitizing the infant should be considered.

✔️ Precautions & Warnings

Use with caution in patients receiving concurrent treatment with potent diuretics and those with a history of colitis.

✔️ Storage Conditions:

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.