Generic Name: Cefuroxime 125 mg + Clavulanic Acid 31.25 mg/5 ml Manufacturer/Distributor: Opsonin Pharma Limited
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Clavusef 70 ml Suspension is prescribed to treat infections caused by sensitive bacteria.
Cefuroxime is a bactericidal second-generation cephalosporin antibiotic that kills a wide spectrum of Gram-positive and Gram-negative bacteria, including many beta-lactamase-producing strains. Cefuroxime works by interfering with the transpeptidation process, which stops bacteria from making cell walls.
Streptomyces clavuligerus produces clavulanic acid, a naturally derived beta lactamase inhibitor. It has a structure comparable to beta lactam antibiotics, and it binds to beta-lactamase enzymes and inactivates them irreversibly. Clavulanic acid protects Cefuroxime against breakdown by beta lactamase enzymes, making it an effective therapy for beta lactamase-related bacterial infections.
Adolescents and adults (13 years and older)-
Paediatric Patients (3 months to 12 years)-
Cefuroxime-Clavulanic Acid tablets should not be taken with meals.
The area under the serum concentration versus time curve increases by 50% when probenecid and Cefuroxime-Clavulanic Acid are given together. A drug that lowers stomach acidity may diminish Cefuroxime bioavailability and negate the impact of postprandial absorption.
Clavusef 70 ml Suspension is not recommended for people who have a documented cephalosporin allergy or who have Pseudomembranous Colitis.
Clavusef 70 ml Suspension is generally well tolerated. However, nausea, vomiting, diarrhea, stomach discomfort, or pain are possible adverse effects. Prolonged use of Cefuroxime and Clavulanic acid together, like other broad-spectrum antibiotics, can lead to nonsusceptible microorganism overgrowth. Renal failure, allergy, angioedema, and pruritis occur seldom (0.2 percent).
Antibiotics should be avoided if at all feasible throughout the first trimester. Cefuroxime-Clavulanic Acid, on the other hand, can be safely used to treat urinary and other infections later in pregnancy. Cefuroxime-Clavulanic Acid is excreted in tiny amounts in breast milk. However, the potential of the child being sensitized should be considered.
Cefuroxime should be used with caution in individuals who are taking strong diuretics and have a history of colitis.
Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.
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