Clavusef 250mg Tablet

Uses of Clavusef 250mg Tablet

Bacterial Infections.

How does Clavusef 250mg Tablet work?

Cefuroxime acts by inhibiting the cell wall synthesis of bacteria, which is responsible for bacterial infection. However, bacteria make an enzyme (beta-lactamases), which can destroy cefuroxime. Clavulanic acid inactivates this enzyme and hence helps cefuroxime to function optimally.

Side effects of

• Diarrhea
• Abdominal Pain
• Confusion
• Fever
• Redness Of Skin
• Change In Taste
• Constipation
• Dizziness

Quick Suggestions:

• Clavusef 250mg Tablet is used to treat various types of bacterial infections in the body of the urinary tract, respiratory tract, and sexually transmitted diseases.
• Take this capsule in the exact dose and duration as prescribed by the doctor.
• Complete the entire course of treatment with this medicine as prescribed by your doctor. Do not miss any dose and do not take more than the prescribed dose.
• Inform your doctor if you are pregnant, planning on becoming pregnant, or breastfeeding before starting the Clavusef 250mg Tablet.
• Also, inform your doctor about all other medicines that you take and your complete medical history.
• Diarrhea, nausea, vomiting, stomach pain, and indigestion can be seen as side effects of this medicine, inform your doctor if the side effects do not resolve over time.
• Inform your doctor if you have an allergy to this medicine or penicillin antibiotics.

Indication

Clavusef 250mg Tablet is used for the treatment of various bacterial infections such as:

• Pharyngitis and/or tonsillitis
• Acute bacterial otitis media
• Acute bacterial maxillary sinusitis
• Lower respiratory tract infections including pneumonia
• Acute bacterial exacerbations of chronic bronchitis and secondary bacterial infections of acute bronchitis
• Skin and skin structure infections
• Urinary tract infections
• Bone and joint infections
• Gonorrhoea (uncomplicated and disseminated gonococcal infections)
• Early Lyme disease (erythema migrans)
• Septicemia
• Meningitis
• Switch therapy (injectable to oral) after surgery when the patient’s condition is improved

Pharmacology

Cefuroxime, the cephalosporin antibiotic in Clavusef 250mg Tablet, works by binding to one or more of the penicillin-binding proteins (PBPs) in the bacterial cell wall. PBPs are enzymes involved in the synthesis of peptidoglycan, a crucial component of the bacterial cell wall. By binding to these PBPs, Cefuroxime inhibits the final transpeptidation step of peptidoglycan synthesis, which is essential for the assembly and integrity of the bacterial cell wall. As a result, bacterial cell wall biosynthesis is disrupted, leading to cell wall defects and ultimately bacterial cell death.

Clavulanic acid, the beta-lactamase inhibitor in Clavusef 250mg Tablet, serves to enhance the activity of Cefuroxime against certain bacteria. Beta-lactamases are enzymes produced by bacteria that can inactivate and degrade beta-lactam antibiotics, including Cefuroxime, by hydrolyzing the beta-lactam ring present in these antibiotics. Clavulanic acid has a high affinity for and binds to specific beta-lactamases, rendering them inactive. By inhibiting beta-lactamase activity, Clavulanic acid prevents the degradation of Cefuroxime by beta-lactamases, allowing Cefuroxime to exert its antibacterial effect effectively.

The addition of Clavulanic acid to Cefuroxime in Clavusef 250mg Tablet broadens the spectrum of bacteria that can be effectively targeted. It extends the antibacterial activity of Cefuroxime to include bacteria that are normally resistant to Cefuroxime and other penicillins and cephalosporins due to the production of beta-lactamases. By inhibiting beta-lactamase activity, Clavulanic acid enhances the effectiveness of Cefuroxime against these resistant bacteria.

Dosage & Administration of Clavusef 250mg Tablet

Adult Dose:

• Pharyngitis or Tonsillitis: 250 mg twice daily for 5-10 days.
• Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days.
• Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily for 10 days.
• Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily for 5-10 days.
• Community-acquired pneumonia: 250-500 mg twice daily for 5-10 days.
• Uncomplicated skin & skin-structure infections: 250-500 mg twice daily for 10 days.
• MDR (Multi-Drug Resistant) Typhoid fever: 500 mg twice daily for 10-14 days.
• Uncomplicated urinary tract infection: 250 mg twice daily for 7-10 days.
• Uncomplicated gonorrhea: 1000 mg single dose.
• Lyme disease: 500 mg twice daily for 20 days.

Child Dose (Paediatric patients, 3 months to 12 years):

• Pharyngitis or Tonsillitis: 20 mg/kg/day in two divided doses for 5-10 days.
• Acute otitis media: 30 mg/kg/day in two divided doses for 10 days.
• Acute bacterial maxillary sinusitis: 30 mg/kg/day in two divided doses for 10 days.
• Community-acquired pneumonia: 30 mg/kg/day in two divided doses for 5-10 days.
• MDR Typhoid fever: 30 mg/kg/day in two divided doses for 10-14 days.
• Uncomplicated skin & skin-structure infections: 30 mg/kg/day in two divided doses for 10 days.
• Uncomplicated urinary tract infection: 20 mg/kg/day in two divided doses for 7-10 days.

Please note that these dosage recommendations are provided as a general guideline. The actual dosage and duration of treatment may vary based on individual factors and the specific instructions given by your healthcare provider. It is important to consult with a doctor or healthcare professional for personalized dosing instructions and to ensure appropriate use of the medication.

Interaction

• Antacids (Esomeprazole, Omeprazole): There may be a potential interaction between Clavusef 250mg Tablet and antacids that contain esomeprazole or omeprazole. These antacids can reduce the absorption of Clavusef 250mg Tablet, so it is generally recommended to take them at different times or with a time gap between doses. It's best to follow your doctor's instructions on how to take these medications together.
• Anticoagulants (Warfarin): Clavusef 250mg Tablet may interact with anticoagulants such as warfarin. Clavusef 250mg Tablet can affect the metabolism and clearance of warfarin, potentially increasing the risk of bleeding. Close monitoring of your clotting parameters (INR) is important if you are taking both medications together. Your doctor may need to adjust the dosage of warfarin if necessary.
• Anti-gout (Probenecid): Probenecid, an anti-gout medication, can interact with Clavusef 250mg Tablet. Probenecid can inhibit the excretion of Clavusef 250mg Tablet, leading to increased levels of Clavusef 250mg Tablet in the blood. Your doctor may need to adjust the dosage of Clavusef 250mg Tablet if you are also taking probenecid.
• Diuretics (Furosemide): There may be an interaction between Clavusef 250mg Tablet and diuretics like furosemide. Furosemide can increase the concentration of Clavusef 250mg Tablet in the blood by reducing its elimination. Your doctor may need to monitor your response to Clavusef 250mg Tablet if you are taking it concomitantly with furosemide.
• Oral Contraceptives (Estrogen, Progesterone): Clavusef 250mg Tablet Tablet may interfere with the effectiveness of oral contraceptives. It is recommended to use additional methods of contraception, such as barrier methods while taking Clavusef 250mg Tablet to ensure adequate contraception.
• Regarding drug-food interactions, no specific interactions have been established for Clavusef 250mg Tablet with food.
• For drug-disease interactions, it is important to inform your doctor if you have colitis, seizures, are undergoing dialysis, or have kidney and liver dysfunction. These conditions may require special monitoring or dosage adjustments when taking Clavusef 250mg Tablet.
• It's crucial to consult with your doctor or healthcare professional about any specific drug interactions or concerns you may have, as they can provide personalized advice based on your medical history and current medications.

Contraindications

If you are allergic to cefuroxime or clavulanic acid or any of the ingredients of the Clavusef 250mg Tablet.

If you have a history of a severe allergy to any other antibiotics like penicillins.

Pregnancy & Lactation

Antibiotics should be avoided if at all possible throughout the first trimester. Cefuroxime-Clavulanic Acid, on the other hand, can be safely used to treat urinary and other infections later in pregnancy. Cefuroxime-Clavulanic Acid is excreted in modest amounts in breast milk. However, the possibility of the newborn being sensitized should be considered.

Precautions & Warnings

• Allergy and Pre-existing Conditions: It is crucial to inform your doctor if you have any allergies, especially to antibiotics, or if you have kidney or liver problems. These factors can influence the suitability and dosage adjustments of Clavusef 250mg Tablet for your specific situation.
• Avoid Self-Medication: It is important not to take Clavusef 250mg Tablet on your own without proper medical advice. Self-medication can lead to antibiotic resistance, where antibiotics become ineffective against specific bacterial infections. Always consult your doctor before initiating treatment with Clavusef 250mg Tablet.
• Colitis: If you have colitis, which refers to inflammation of the colon, it is necessary to consult your doctor before taking Clavusef 250mg Tablet. They can assess the potential risks and benefits and determine the most appropriate course of action.
• Concurrent Use with Potent Diuretics: If you are receiving treatment with potent diuretics, it is important to use Clavusef 250mg Tablet with caution. Your doctor can monitor your response to treatment and make any necessary dosage adjustments.
• Pregnancy and Breastfeeding: If you are pregnant or planning for pregnancy, it is essential to consult your doctor before taking Clavusef 250mg Tablet. Similarly, if you are breastfeeding, it is advisable to avoid Clavusef 250mg Tablet as it may pass into breast milk and could potentially affect the nursing infant.
• Alcohol Consumption: It is recommended to avoid alcohol consumption while taking Clavusef 250mg Tablet. Alcohol can interact with the medication and may cause unpleasant side effects or reduce the effectiveness of the treatment.

Storage Conditions

Store the Clavusef 250mg Tablet at room temperature, protected from light and moisture.

Keep it out of the reach of children and pets.