Bacron Ointment is indicated for the topical treatment of skin infections such as impetigo caused by Staphylococcus aureus and Streptococcus pyogenes. It is also effective in managing folliculitis and furunculosis.
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Mupirocin is a naturally occurring topical antibiotic produced by the fermentation of Pseudomonas fluorescens. It exhibits strong antibacterial activity against a wide spectrum of pathogens commonly responsible for skin infections, including Staphylococcus aureus (both methicillin-sensitive and methicillin-resistant strains), Streptococcus pyogenes, and certain Gram-negative bacteria, such as Escherichia coli and Haemophilus influenzae.
The drug acts by inhibiting bacterial protein synthesis through reversible and specific binding to bacterial isoleucyl-tRNA synthetase. This unique mechanism minimizes the risk of cross-resistance with other classes of antibiotics. Mupirocin demonstrates bactericidal activity at topical concentrations, although its minimum bactericidal concentration (MBC) is typically 8–30 times higher than the minimum inhibitory concentration (MIC).
Apply a small amount of Bacron Ointment to the affected area three times daily for up to 10 days, or as directed by a physician.
Pediatric Use:
Safety and efficacy have been established in children aged 2 months to 16 years, based on well-controlled clinical studies in pediatric impetigo.
No clinically significant drug interactions have been reported with Bacron Ointment.
Bacron Ointment is contraindicated in patients with known hypersensitivity to Mupirocin or any component of the formulation.
Adverse reactions are generally mild and localized, including:
Animal studies have shown no evidence of fetal harm. However, due to limited clinical experience in pregnant women, Mupirocin should be used during pregnancy only if the potential benefit justifies the possible risk.
It is unknown whether Mupirocin is excreted in human milk; therefore, caution is advised when used by nursing mothers.
Store below 25°C, protected from light and moisture.
Do not freeze. Keep out of reach of children.
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