Axim 500mg Tablet 1 Strip

✔️ Parenteral Administration

Injectable cefuroxime should be administered by a qualified healthcare professional.

Adults:

• Usual dose: 750 mg three times daily by IM or IV injection.
• For severe infections: up to 1.5 g three times daily by IV injection may be used.
• In some severe infections, the frequency may be increased to four times daily under specialist supervision.

Children above 3 months:

• 30–100 mg/kg/day in 3 or 4 equally divided doses.
• A dose of 60 mg/kg/day is appropriate for many infections.

Neonates:

• 30–100 mg/kg/day in 2 or 3 equally divided doses.

Surgical prophylaxis:

• 1.5 g IV at induction of anaesthesia. Additional doses may be given according to the surgical procedure and clinical risk.

Pneumonia:

• 1.5 g IV twice daily for 2–3 days, followed by appropriate oral therapy when clinically indicated.

Acute exacerbation of chronic bronchitis:

• 750 mg IM or IV twice daily for 2–3 days, followed by 500 mg orally twice daily for 5–10 days when clinically appropriate.

Gonorrhoea:

• 1.5 g as a single IM dose may be used according to the prescribed regimen.

Meningitis:

• Adults: 3 g IV three times daily.
• Children above 3 months: 200–240 mg/kg/day IV in 3 or 4 divided doses, subsequently reduced according to clinical improvement.
• Neonates: dosing should be individualized by the treating physician.

Bone and joint infections:

• Adults: 1.5 g IV four times daily.
• Children above 3 months: up to 150 mg/kg/day in divided doses, without exceeding the recommended adult maximum.

✔️ Oral Tablet or Suspension | Cefuroxime

Adults and adolescents 13 years and older:

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days.
• Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days.
• Acute exacerbation of chronic bronchitis: 250–500 mg twice daily for 10 days.
• Secondary bacterial infection of acute bronchitis: 250–500 mg twice daily for 5–10 days.
• Uncomplicated skin and skin-structure infections: 250–500 mg twice daily for 10 days.
• Uncomplicated urinary tract infections: 250 mg twice daily for 7–10 days.
• Uncomplicated gonorrhoea: 1,000 mg as a single dose.
• Community-acquired pneumonia: 250–500 mg twice daily for 5–10 days.
• MDR typhoid fever: 500 mg twice daily for 10–14 days.
• Early Lyme disease: 500 mg twice daily for 20 days.

Children 3 months to 12 years:

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses for 5–10 days.
• Acute otitis media: 30 mg/kg/day in two divided doses for 10 days.
• Acute bacterial maxillary sinusitis: 30 mg/kg/day in two divided doses for 10 days.
• Impetigo: 30 mg/kg/day in two divided doses for 10 days.

The exact dose and duration should be determined by the treating physician based on the infection, age, body weight, kidney function, and clinical response.

✔️ Cefuroxime is generally well tolerated. Possible side effects include:

• Nausea, vomiting, diarrhoea, or abdominal discomfort
• Skin rash or itching
• Headache or dizziness
• Injection-site pain or irritation with parenteral administration
• Temporary changes in liver enzymes
• Candida overgrowth with prolonged antibiotic use

✔️ Axim is contraindicated in patients with:

• Known hypersensitivity to cefuroxime or other cephalosporin antibiotics.
• A history of severe immediate hypersensitivity reactions to beta-lactam antibiotics should be carefully considered before treatment.

✔️ Drug Interactions

No major clinically significant interactions are commonly expected, but patients should inform their doctor about all medicines they are taking. Particular caution may be required with medicines that can affect kidney function or with drugs that may alter cefuroxime elimination.

✔️ Pregnancy & Lactation

Cefuroxime should be used during pregnancy only when clearly indicated by a healthcare professional. Cefuroxime can pass into breast milk; therefore, caution is advised when it is administered to breastfeeding women. Consult a doctor before using this medicine during pregnancy or lactation.

✔️ Precautions and Warnings

• Use cefuroxime only for bacterial infections that are susceptible to the medicine.
• Use with caution in patients with a history of colitis or significant gastrointestinal disease.
• Dose adjustment may be necessary in patients with impaired kidney function.
• Patients receiving potent diuretics should be monitored, particularly when renal function is compromised.
• Patients with a history of severe allergy to penicillins or other beta-lactam antibiotics should inform their doctor before treatment because cross-hypersensitivity can occur.
• Prolonged or repeated use may result in overgrowth of non-susceptible organisms, including fungi.
• Seek medical attention if severe or persistent diarrhoea develops during or after treatment.

✔️ Storage:

• Store below 30°C in a cool, dry place.
• Protect from light and moisture.
• Keep out of reach of children.
• Reconstituted injectable preparations should be stored only according to the manufacturer's specified conditions and used within the recommended stability period.