Manufacturer/Distributor: Opsonin Pharma Limited
Generic Name: Prednisolone 5 mg
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Precodil is a steroid. It is used for treatment of wide variety of medical conditions such as severe allergic reactions, asthma, rheumatic disorders and skin and eye disorders. It provides relief by preventing the release of substances that cause inflammation and by suppressing the immune system. Precodil should be taken with food to avoid an upset stomach. It should be swallowed whole with water at the same time(s) each day. Your doctor will decide the dose and how often you should take them. This may change from time to time depending on how well they are working. You should take this medicine regularly to get the most benefit, even if you feel fine. The most common side effect of this medicine is reduction in bone density, weight gain, mood changes, upset stomach, and behavioural changes. Talk to your doctor if these bother you or do not go away. Taking Precodil can also make it harder for you to fight off infections. Tell your doctor if you have any signs of infection such as fever or sore throat. Let your doctor know about any medical issues you have, especially poor blood circulation, diabetes and immune system problems and about other medicines you are taking (particularly steroids).
Uses of Precodil
Side effects of Precodil
Common
How to use Precodil
Take this medicine in the dose and duration as advised by your doctor. Dissolve it in a glass of water before taking it. Precodil may be taken with or without food, but it is better to take it at a fixed time.
How Precodil works
Precodil is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.
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Brief Description
Indication
Rheumatoid arthritis, Multiple sclerosis, Allergic and inflammatory disorders, Nephrotic syndrome, Idiopathic thrombocytopenic purpura, Joint inflammations, Moderate to severe asthma, Infantile spasms
Administration
Should be taken with food.
Adult Dose
Oral Allergic and inflammatory disorders Adult: 5-60 mg daily in 2-4 divided doses. Maintenance: 2.5-15 mg daily. Withdrawal should be gradual after long-term therapy. Poorly controlled, moderate to severe asthma, COPD Adult: Patients with at least 2 exacerbations/yr requiring oral corticosteroids: 40-60 mg daily in 1-2 divided doses; usually given as a short course treatment over 10-14 days until symptom resolution and patient achieves a peak expiratory flow (PEF) of at least 80% of his or her personal best. Rheumatoid arthritis Adult: Initially, 5-7.5 mg daily, adjusted as necessary. Elderly: 5 mg daily. Multiple sclerosis Adult: 200 mg daily for 1 wk followed by 80 mg every other day for 1 mth. Bells Palsy 60 mg PO qDay for 5 days; then taper down by 10 mg daily for 5 days for total duration time of 10 days
Child Dose
Inflammation 0.1-2 mg/kg/day PO in single daily dose or divided q6-12hr; not to exceed 80 mg/day Acute Asthma 1-2 mg/kg/day in single daily dose or divided q12hr for 3-5 days Nephrotic Syndrome First 4 weeks: 60 mg/m²/day or 2 mg/kg/day PO divided q8hr until urine is protein free for 3 consecutive days; not to exceed 28 days; dose not to exceed 80 mg/day Subsequent 4 weeks: 40 mg/m² or 1-1.5 mg/kg PO every other day; not to exceed 80 mg/day Maintenance in frequent relapses: 0.5-1 mg/kg/dose PO every other day for 3-6 months Idiopathic thrombocytopenic purpura Child: 1-10 yr: 1-2 mg/kg daily (max: 14 days) or 4 mg/kg daily (max: 4 days).
Contraindication
Live vaccines; herpes simplex keratitis, systemic infections.
Mode of Action
Prednisolone decreases inflammation by inhibition of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system by reducing the activity and production of the lymphocytes and eosinophils.
Precaution
Patients with hypothyroidism, cirrhosis, ulcerative colitis, CHF, convulsive disorders, thrombophlebitis, peptic ulcer, elderly. DM, hypertension, psychological disturbances, osteoporosis; pregnancy, lactation. Adrenal suppression and infection. May cause irreversible growth retardation, glaucoma, corneal perforation. Lactation: Excreted in breast milk; use caution
Side Effect
Acne,Adrenal suppression,Delayed wound healing,Diabetes mellitus,GI perforation,Glucose intolerance,Hepatomegaly,Hypokalemic alkalosis,Increased transaminases,Insomnia,Menstrual irregularity,Myopathy,Neuritis,Osteoporosis,Peptic ulcer,Perianal pruritus,Pituitary adrenal axis suppression,Pseudotumor cerebri (on withdrawal),Psychosis,Seizure,Ulcerative esophagitis,Urticaria,Vertigo,Weight gain Potentially Fatal: Acute adrenal insufficiency precipitated by infection, trauma or surgery in patients on long-term therapy or following cessation of such therapy. CV collapse following rapid IV injection.
Interaction
Efficacy may be reduced by phenytoin, phenobarb, rifampicin. Corticoids may reduce the effects of diuretics, hypoglycaemics, anticholinesterases, salicylates.
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