Precodil 20mg (10pcs)

Psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute and subacute bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, post-traumatic osteoarthritis are all examples of rheumatic disorders. Primary or secondary adrenocortical insufficiency, congenital adrenal hyperplasia, nonsuppurative thyroiditis, hypercalcemia linked with malignancy are all examples of endocrine disorders. Pemphigus, bullous dermatitis herpetiformis, severe erythema multiforme, exfoliative dermatitis, mycosis fungoides, and severe psoriasis are all dermatologic diseases. Seasonal or perennial allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, serum sickness, and medication hypersensitivity responses are examples of allergic states. Symptomatic sarcoidosis, berylliosis, fulminating, aspiration pneumonitis are examples of respiratory diseases. Idiopathic thrombocytopenic purpura, secondary thrombocytopenia, acquired (autoimmune) hemolytic anemia, erythroblastopenia are all examples of hematologic disorders (RBC anemia).

Edema: To produce diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic or lupus erythematosus type. Ulcerative colitis and regional enteritis are two gastrointestinal diseases.

Pharmacology

Prednisolone is a glucocorticoid-primarily adrenocorticoid adrenocorticoid adrenocorticoid adrenocorticoid adrenocorticoid Prednisolone directly inhibits the Phospholipase A2 enzyme, which is responsible for the synthesis of many inflammatory mediators such as leukotrienes, SRS-A, prostaglandins, and others. Following oral treatment, prednisolone is promptly and thoroughly absorbed from the GI system. Prednisolone is protein-bound in the plasma at 70-90 percent and is removed with a half-life of 2 to 4 hours. It is mostly processed in the liver and eliminated in the urine.

Dosage & Administration

Adult-

Nephrotic Syndrome:

• Initial: 2 mg/kg/day (maximum 80 mg/day) in divided doses 3 to 4 times/day until urine is protein free for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose given every other day for 4 weeks.
• Maintenance dose: 0.5 to 1 mg/kg/ dose given every other day for 3 to 6 months.

Anti-inflammatory: 5 to 60 mg per day in divided doses 1 to 4 times/day.

Acute Asthma: 40-60 mg/day PO in single daily dose or divided q12 hr for 3-10 days.

Allergic Conditions:

• Day 1: 10 mg PO before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime.
• Day 2: 5 mg PO before breakfast, after lunch, and after dinner and 10 mg at bedtime.
• Day 3: 5 mg PO before breakfast, after lunch, after dinner, and at bedtime.
• Day 4: 5 mg PO before breakfast, after lunch, and at bedtime.
• Day 5: 5 mg PO before breakfast and at bedtime.
• Day 6: 5 mg PO before breakfast.

Pediatric-

Asthma:

• 1 year: Acute: 10 mg orally every 12 hours. Maintenance: 10 mg orally every other day.
• 1 to 4 years: Acute: 20 mg orally every 12 hours. Maintenance: 20 mg orally every other day.
• 5 to 12 years: Acute: 30 mg orally every 12 hours. Maintenance: 30 mg orally every other day.
• 12 years: Acute: 40 mg orally every 12 hours. Maintenance: 40 mg orally every other day.

Anti-inflammatory: 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

Immunosuppression: 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

Interaction

Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone, and Rifampin all diminish the effectiveness of prednisolone. Prednisolone lowers the level of potassium in the blood. If hypokalemia occurs, digitalis can induce cardiac arrhythmias. Immunization should be done with extreme caution.

Contraindications

Unless specialized anti-infective medication is used, systemic infections can occur. Any component can cause hypersensitivity. Because of the possibility of perforation, ocular herpes simplex.

Side Effects

Increased hunger, indigestion, anxiety, or restlessness are common adverse effects. Darkening or lightening of skin tone, dizziness or lightheadedness, flushing of the face or cheeks, hiccups, increased perspiration, and the impression of spinning are less common or unusual adverse effects.

Pregnancy & Lactation

This medication is not suggested for use during pregnancy unless your doctor deems it necessary. It should be used only if the predicted benefit to the mother outweighs any potential danger to the unborn. Corticosteroids are found in breast milk and have the potential to inhibit development, interfere with endogenous corticosteroid synthesis, and produce other undesirable consequences.

Precautions & Warnings

Diabetes, hypertension, psychological disorders, osteoporosis, postmenopausal women, pregnancy, and chronic nephritis all necessitate vigilance. Prednisolone usage for an extended period of time can result in Cushing's syndrome, hyperglycemia, muscle weakness, increased susceptibility to infection, delayed wound healing, and mental problems.