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Dinogest is prescribed for the treatment of endometriosis. It belongs to the progestin class of medications, which work by reducing the effects of estrogen on tissues such as the endometrium (uterine lining) and breasts. By limiting estrogen’s influence, Dinogest helps reduce pelvic pain associated with endometriosis.
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✅ Description:
Dienogest functions as a progesterone receptor (PR) agonist with weak receptor affinity but strong progestagenic effects on the endometrium, leading to endometrial atrophy with prolonged use. It exhibits antiproliferative, immunologic, and antiangiogenic properties, suppressing both normal and ectopic endometrial tissue growth by reducing endogenous estradiol levels.
Continuous use of Dienogest creates a high-progesterone, moderately low-estrogen environment, initially causing decidualization (thinning) of the endometrial lining. Additionally, it has anti-androgenic properties, which may help improve acne and hirsutism.
✔️ Dinogest 2: Most side effects occur within the first few months of treatment and tend to decrease over time.
- Common side effects:
- Headache (9%)
- Breast tenderness (5.4%)
- Depressed mood (5.1%)
- Acne (5.1%)
- Other possible side effects:
- Nervous system: Migraine, irritability, mood changes
- Cardiac: Palpitations, circulatory issues (uncommon)
- Vascular: Low blood pressure (uncommon)
- Gastrointestinal: Nausea, abdominal pain, bloating
- Metabolic: Weight gain (3.6%)
✔️ Dosage & Administration
- Starting the medication: Treatment can begin on any day of the menstrual cycle.
- Recommended dose: 2 mg per day without interruption, taken at the same time daily with or without food.
- Missed doses: If a dose is missed, the patient should take only 2 mg as soon as they remember and continue with the next scheduled dose.
- Vomiting or diarrhea: If a tablet is not absorbed due to vomiting or diarrhea, a replacement 2 mg dose should be taken.
- Children: Not recommended for use before the onset of menstruation. The safety and effectiveness in adolescents (under 18 years) have not been well established.
- Elderly: Not intended for use in postmenopausal women.
✔️ Dinogest 2: Direction of Use:
Take Dinogest 2 in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush, or break it. Dinogest 2 may be taken with or without food, but it is better to take it at a fixed time.
✔️ Drug Interactions
Dienogest is metabolized primarily by the CYP3A4 enzyme. Medications that induce or inhibit CYP3A4 can alter Dienogest levels in the body.
- CYP3A4 inhibitors (increase Dienogest levels):
- Azole antifungals: Ketoconazole, Itraconazole, Fluconazole
- Macrolide antibiotics: Erythromycin, Clarithromycin, Roxithromycin
- Calcium channel blockers: Verapamil, Diltiazem
- Protease inhibitors: Ritonavir, Saquinavir, Indinavir, Nelfinavir
- Antidepressants: Nefazodone, Fluvoxamine, Fluoxetine
- Cimetidine (used for stomach ulcers and reflux)
✔️ Dinogest should not be used in individuals with:
- Hypersensitivity to Dienogest or its ingredients
- Active venous thromboembolism (VTE)
- Cardiovascular diseases (heart attack, stroke, ischemic heart disease)
- Diabetes with vascular complications
- Severe liver disease or liver tumors
- Hormone-dependent cancers (e.g., breast cancer)
- Unexplained vaginal bleeding
✔️ Pregnancy & Lactation
- Pregnancy: While no harmful effects have been observed in animal studies or pregnant women, Dienogest should not be used during pregnancy, as endometriosis treatment is unnecessary during this period.
- Breastfeeding: Not recommended, as the drug may pass into breast milk. A decision should be made whether to discontinue breastfeeding or stop Dienogest treatment.
✔️ Precautions & Warnings
- Pregnancy prevention: Women should confirm they are not pregnant before starting Dinogest. If contraception is needed, nonhormonal methods (e.g., barrier methods) are recommended.
- Menstrual cycle changes: Most women experience irregular bleeding patterns during treatment.
- Liver disease: Contraindicated in individuals with current or past severe liver disease.
- Fertility concerns: Ovulation is usually suppressed while on Dinogest, but the drug is not a contraceptive.
✔️ Storage Conditions
- Store below 30°C, away from light and moisture.
- Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
