Ruvan Z 5/10 Tablet

✔️ How Ruvan Z 5/10 Works

Ruvan Z 5/10 Tablet contains two lipid-lowering medicines that work through complementary mechanisms.

Rosuvastatin inhibits HMG-CoA reductase, an enzyme involved in cholesterol production in the liver. This increases the removal of LDL cholesterol from the blood and lowers LDL and other atherogenic lipid levels.

Ezetimibe reduces the absorption of dietary and biliary cholesterol from the small intestine by inhibiting the NPC1L1 cholesterol transporter.

Together, these medicines provide a greater reduction in LDL cholesterol than either medicine alone and help reduce cholesterol-related cardiovascular risk when used appropriately.

✔️ How to Take Ruvan Z 5/10 Tablet

• Take Ruvan Z 5/10 Tablet exactly as prescribed by your doctor.
• It may be taken with or without food.
• Swallow the tablet whole with a glass of water.
• Do not crush or chew the tablet.
• Try to take it at the same time each day.
• Continue your prescribed diet and exercise programme during treatment.
• Do not stop treatment without consulting your doctor.

The dose and duration of treatment depend on your cholesterol level, cardiovascular risk, response to treatment, kidney function, and other medical conditions.

✔️ Side Effects:

• Headache
• Dizziness
• Constipation
• Nausea
• Diarrhea
• Abdominal discomfort or stomach pain
• Flatulence
• Muscle pain
• Weakness or fatigue
• Increased blood glucose levels
• Increased liver enzyme levels
• Protein in the urine

✔️ Stop taking the medicine and seek immediate medical attention if you develop:

• Severe or unexplained muscle pain, tenderness, or weakness, particularly if accompanied by fever or reddish-brown urine, as this may indicate serious muscle injury.
• Severe allergic reactions, including swelling of the face, lips, tongue, or throat, difficulty breathing or swallowing, wheezing, severe dizziness, fainting, hives, or widespread rash.
• Severe skin reactions, including blistering, peeling, or extensive skin rash, especially when accompanied by fever or joint pain.
• Possible liver problems, such as unusual tiredness or weakness, loss of appetite, upper abdominal pain, dark urine, yellowing of the skin or eyes, nausea, or vomiting.

✔️ Before taking Ruvan Z 5/10 Tablet, inform your doctor if you:

• Have diabetes
• Are overweight or obese
• Have high blood pressure
• Have thyroid problems, particularly untreated hypothyroidism
• Have kidney or liver disease
• Have a history of muscle pain or weakness during treatment with cholesterol-lowering medicines
• Have a personal or family history of muscle disorders
• Consume large amounts of alcohol
• Have previously experienced liver or muscle problems with statin therapy

✔️ Management of Common Side Effects

Constipation

Eat fibre-rich foods such as fresh fruits, vegetables, and whole grains. Drink adequate fluids and maintain regular physical activity. Consult your doctor if constipation persists.

Dizziness

Rest and avoid driving or operating machinery while you feel dizzy. Avoid excessive alcohol consumption, as it may worsen dizziness.

Headache

Rest, stay adequately hydrated, and avoid excessive alcohol consumption. Consult your doctor if the headache is severe or persistent.

Nausea

Take the medicine as directed, with or without food. Choose simple meals and avoid foods that worsen your symptoms. Consult your doctor if nausea persists or becomes severe.

✔️ Drug Interactions

Inform your doctor about all medicines, supplements, and herbal products you are taking. Important interactions may occur with:

• Cyclosporine, which can substantially increase rosuvastatin exposure
• Gemfibrozil and other fibrates, which may increase the risk of muscle toxicity
• Warfarin and other anticoagulants, which may require monitoring
• Fusidic acid, particularly systemic fusidic acid, because of the risk of serious muscle toxicity with statins
• Certain antiviral medicines used for HIV or hepatitis C, which may increase rosuvastatin exposure
• Regorafenib and certain other medicines that can affect rosuvastatin concentrations
• Bile acid sequestrants, such as cholestyramine and colesevelam, which can reduce ezetimibe absorption; appropriate separation between doses may be required
• Antacids containing aluminium or magnesium, which can reduce rosuvastatin absorption; they should generally be taken at least 2 hours after rosuvastatin
• Other lipid-lowering medicines, particularly fibrates and high-dose niacin, which may increase the risk of muscle-related adverse effects

✔️ Who Should Not Take Ruvan Z 5/10 Tablet?

Ruvan Z 5/10 Tablet may not be suitable for patients who:

• Are allergic to ezetimibe, rosuvastatin, or any component of the medicine
• Are pregnant or planning to become pregnant
• Are breastfeeding
• Have active liver disease
• Have unexplained, persistent muscle pain or weakness
• Have previously experienced serious muscle problems associated with statin treatment
• Have certain severe kidney problems requiring dose adjustment or alternative treatment
• Are taking medicines that can significantly increase the risk of rosuvastatin-related muscle toxicity

✔️ Allergy

Do not take Ruvan Z 5/10 Tablet if you are allergic to ezetimibe, rosuvastatin, or any of the other ingredients in the formulation.

✔️ Use in Pediatrics

The safety and effectiveness of the combination product depend on the patient's age and formulation. It should be used in children and adolescents only when prescribed by an appropriate healthcare professional.

✔️ Use in Elderly Patients

Elderly patients may have a higher risk of statin-associated muscle problems, particularly when other risk factors are present. Your doctor may monitor you more closely during treatment.

✔️ Storage:

• Store at room temperature as directed on the product packaging.
• Protect from excessive heat, moisture, and direct light.
• Keep the medicine in its original packaging.
• Keep out of reach and sight of children.
• Do not use the medicine after the expiry date.