Dotfix 2mg Tablet 1 Strip

✔️ Uses of Dotfix 2:

• Treatment of gout: Helps manage and prevent gout attacks by lowering uric acid levels.
• Management of hyperuricemia: Reduces elevated uric acid levels in the blood to prevent crystal formation that causes joint inflammation.

✔️ Common side effects include:

• Gouty arthritis
• Limb discomfort (1% to less than 5% of patients)
• Loose stools
• Increased y-GTP levels
• Arthralgia (joint pain)
• Kidney stones
• Nephrocalcinosis (calcium deposits in kidneys)
• Increased urinary y2 macroglobulin
• Increased blood creatinine levels

✔️ Missed Dose:

If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. If it's near the next dose, skip the missed dose. Never take two doses at once.

✔️ Overdose:

If you accidentally take too much, consult your doctor or pharmacist immediately.

✔️ Dosage & Administration:

• Initial Dose: The usual starting dose is 0.5 mg once daily.
• Gradual Dose Increase: After 2 weeks, increase the dose to 1 mg once daily, and after 6 weeks, increase to 2 mg once daily.
• Maintenance Dose: The maintenance dose is typically 2 mg once daily, but it can be adjusted based on the patient’s condition. The maximum dose is 4 mg once daily.

✔️ Precautions Related to Dosage and Administration:

• In the early stages of treatment, rapid reduction in blood uric acid levels may trigger gouty arthritis attacks (gout flare-ups). Therefore, gradual dose escalation is recommended.
• Patients should be monitored closely when the dose is increased.

✔️ Drug Interactions:

• Pyrazinamide: This drug may weaken the effect of Dotfix because it suppresses uric acid secretion in the kidneys, potentially interfering with Dotfix's ability to increase uric acid excretion.
• Salicylic Acid (Aspirin): This can reduce the effectiveness of Dotfix by suppressing uric acid excretion.

✔️ Contraindications:

Dotfix should not be used in patients with known hypersensitivity to any of its components.

✔️ Pregnancy & Lactation:

• Pregnancy: Dotfix should be used only if the therapeutic benefits outweigh the potential risks. Consult a doctor before use during pregnancy.
• Lactation: Dotfix is excreted in breast milk. Consult your doctor before breastfeeding.

✔️ Precautions & Warnings:

• Gouty Arthritis: Rapid reduction of uric acid levels can trigger gout attacks. If a flare occurs before or during treatment, continue treatment but add medications like colchicine or NSAIDs to manage symptoms.
• Urolithiasis (Kidney Stones): Use Dotfix cautiously in patients with a history of kidney stones, as it may worsen symptoms due to increased uric acid excretion.
• Renal Impairment: Use with caution in patients with renal dysfunction. It should be avoided in patients with oliguria (low urine output) or anuria (no urine output), as it may not be effective.
• Hepatic Impairment: Use Dotfix with caution in patients with liver dysfunction. Close monitoring is necessary due to potential liver damage observed with other uricosuric agents.

✔️ Storage Conditions:

• Store below 30°C, in a dry place, away from light.
• Keep out of reach of children.