Itrakill SB 65mg Capsule

✔️ Side Effects

• Nausea or upset stomach
• Headache
• Dizziness
• Diarrhea or constipation

✔️ For 100 mg and 200 mg Preparations

Non-Systemic Fungal Infections

• Vulvovaginal Candidiasis: 200 mg twice daily for 1 day.
• Pityriasis Versicolor: 200 mg once daily for 7 days.
• Tinea Corporis and Tinea Cruris: 100 mg once daily for 15 days or 200 mg once daily for 7 days.
• Tinea Pedis and Tinea Manuum: 100 mg once daily for 30 days.
• Oropharyngeal Candidiasis: 100 mg once daily for 15 days. In patients with AIDS or neutropenia, the dose may be increased to 200 mg once daily for an additional 15 days.
• Onychomycosis (Nail Fungal Infection):
  • Continuous therapy: 200 mg once daily for 3 months.
  • Pulse therapy: 200 mg twice daily for 7 days, followed by a 21-day treatment-free interval.
  • Two pulse courses are generally recommended for fingernails and three courses for toenails.

Systemic Fungal Infections

• Aspergillosis: 200 mg once daily for 2–5 months; increase to 200 mg twice daily for invasive or widespread infections.
• Candidiasis: 100–200 mg once daily for 3 weeks to 7 months; increase to 200 mg twice daily for severe or disseminated disease.
• Non-Meningeal Cryptococcosis: 200 mg once daily for 10 weeks.
• Cryptococcal Meningitis: 200 mg twice daily for 2–6 months.
• Histoplasmosis: 200 mg once or twice daily for approximately 8 months.
• Maintenance Therapy in AIDS: 200 mg once daily until immune recovery.
• Neutropenia Prophylaxis: 200 mg once daily until immune recovery.

Treatment duration and dosage for systemic infections should be individualized according to clinical response.

✔️ For 65 mg and 130 mg Preparations

Non-Systemic Fungal Infections

• Vulvovaginal Candidiasis: 130 mg twice daily for 1 day.
• Pityriasis Versicolor: 65 mg twice daily for 7 days.
• Tinea Corporis and Tinea Cruris: 65 mg once daily for 15 days or 65 mg twice daily for 7 days.
• Tinea Pedis and Tinea Manuum: 65 mg once daily for 30 days.
• Oropharyngeal Candidiasis: 65 mg once daily for 15 days. In AIDS or neutropenic patients, the dose may be increased to 65 mg twice daily for 15 days.
• Onychomycosis:
  • Continuous therapy: 65 mg twice daily for 3 months.
  • Pulse therapy: 130 mg twice daily for 7 days, repeated after a 21-day interval.
  • Two courses are generally recommended for fingernails and three courses for toenails.

Systemic Fungal Infections

• Aspergillosis: 65 mg twice daily for 2–5 months; increase to 130 mg twice daily if required.
• Candidiasis: 65–130 mg once daily for 3 weeks to 7 months; increase to 65 mg twice daily for severe infections.
• Non-Meningeal Cryptococcosis: 65 mg twice daily for 10 weeks.
• Cryptococcal Meningitis: 130 mg twice daily for 2–6 months.
• Histoplasmosis: 130 mg once or twice daily for approximately 8 months.
• Maintenance Therapy in AIDS: 65 mg twice daily until immune recovery.
• Neutropenia Prophylaxis: 65 mg twice daily until immune recovery.

Dosage and treatment duration should be adjusted based on the patient's response to therapy.

✔️ For 50 mg Capsules (Pediatric Use)

Treatment of Non-Systemic and Systemic Fungal Infections

Applicable for conditions such as:

• Pityriasis versicolor
• Tinea corporis
• Tinea cruris
• Tinea pedis
• Tinea manuum
• Oropharyngeal candidiasis
• Onychomycosis
• Aspergillosis
• Candidiasis
• Non-meningeal cryptococcosis
• Cryptococcal meningitis
• Histoplasmosis

Children Older Than 4 Weeks to Less Than 12 Years

• Usual dose: 1.25–2 mg/kg per dose twice daily (maximum initial dose 100 mg per dose).
• For severe infections, the dose may be increased up to 5 mg/kg per dose twice daily (maximum initial dose 100 mg per dose).
• Further dose adjustments should be guided by therapeutic drug monitoring.
• Doses should be rounded to the nearest 50 mg for easier administration.

Children 12 Years and Older

• Usual dose: 50–100 mg once daily.
• In severe infections, the dose may be increased to 100 mg twice daily.

Prophylaxis in Children 2 Years and Older

• 2.5 mg/kg once daily (maximum initial daily dose 200 mg).
• Dose adjustments should be made according to therapeutic drug monitoring and clinical response.

✔️ Inform your doctor if you are taking any of the following medicines, as they may interact.

• Acid reducers (antacids, PPIs): May lower the absorption of Itraconazole, making it less effective.
• Statins (cholesterol-lowering drugs): Itraconazole can increase the levels of these drugs in your blood, increasing the risk of muscle damage.
• Blood thinners: Taking Itraconazole with certain blood thinners can increase the risk of bleeding.

✔️ Safety Information:

• Monitor your liver: Your doctor may require regular blood tests to check your liver function while you are taking this medicine.
• Check the oral liquid: If you are using the liquid form, inspect the solution before use; it should be clear and free of particles.
• Watch for heart failure signs: Stop taking the medication and seek emergency care if you develop unexpected shortness of breath or swelling in your ankles.
• Limit acid reducers: Avoid taking antacids within 2 hours of taking Itraconazole capsules, as they can prevent the medicine from being absorbed properly.

✔️ Storage:

Store in a cool and dry place away from sunlight