Conasyd 1% Dermal Cream

Uses of Conasyd 1% Dermal Cream

• Fungal infections of the vagina

How does Conasyd 1% Dermal Cream work?

Conasyd 1% Dermal Cream works by stopping the growth of fungi to relieve the symptoms you may have and clear the infection. 

Side Effects of Conasyd 1% Dermal Cream

Occasional local transient and mild irritation. If hypersensitivity reactions develop, treatment should be discontinued, and appropriate therapy instituted.

Quick Suggestions:

• Conasyd 1% Dermal Cream helps treat vaginal fungal infections. It reduces vaginal burning, itching, and discharge.
• It is inserted into the vagina using an applicator, usually at night before going to bed.
• Avoid contact with your eyes. If accidental exposure occurs, rinse immediately with plenty of water.
• It can damage condoms and diaphragms and make them ineffective at preventing pregnancy. Ask your doctor about other suitable methods of preventing pregnancy.
• It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
• Inform your doctor immediately if you get a fever, chills, stomach pain, or a bad-smelling vaginal discharge.
• Inform your doctor if your condition does not improve after 3 days, lasts more than 7 days, or if the infection returns within two months.

Indications:

Tioconazole is employed for the local treatment of vulvovaginal candidiasis (moniliasis). Confirmation of the diagnosis is recommended through KOH smears and/or cultures, focusing on candidal vulvovaginitis. Other microorganisms causing vulvovaginitis should be ruled out with appropriate tests. Studies have indicated a comparable cure rate for women taking oral contraceptives and those not taking such agents when treated with Tioconazole.

Pharmacology

Tioconazole binds to 14-demethylase, a cytochrome P-450 enzyme, inhibiting ergosterol synthesis, a crucial component of yeast membranes. This action leads to increased cellular permeability. Tioconazole may also affect endogenous respiration, interact with membrane phospholipids, inhibit yeast transformation, and impede ion transport pathways.

Dosage & Administration:

• Topical Application: Apply and massage gently into the affected and surrounding skin area once or twice a day. In intertriginous areas, apply sparingly to avoid maceration. Duration of use ranges from 1-6 weeks.
• Vaginal Candidiasis: For adults, administer intravaginally at bedtime as a single dose. For children aged 12 and above, administer at bedtime as a single dose.

Interaction

Conasyd should not be administered with food. Studies have indicated a significant reduction in the bioavailability of isoniazid when administered with food.

Contraindications

Tioconazole is contraindicated in individuals sensitive to imidazole antifungal agents or other components of the ointment.

Pregnancy & Lactation

Pregnancy Category C: Use during pregnancy should be considered only if the potential benefits justify the potential risks to the fetus. Studies in animals have shown adverse effects, but controlled studies in women are not available.

Precautions & Warnings

Not for ophthalmic use.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.