Amphoject is indicated for the following:
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Systemic Fungal Infections-
* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Increased toxicity with flucytosine. Drug induced renal toxicity enhanced in presence of other nephrotoxic medications. Antagonises effects of azole antifungals.
Amphotericin B is contraindicated in those patients who have demonstrated or have known hypersensitivity to amphotericin B deoxycholate or any other constituents of the product unless, in the opinion of the treating physician, the benefit of therapy outweighs the risk.
Common side effects are Fever, chills, convulsions, malaise; nausea, vomiting, diarrhoea, anorexia; tinnitus, vertigo, hearing loss; hypotension, hypertension, cardiac arrhythmias; peripheral neuropathy; phloebitis, pain at Inj site, disturbances in renal function and renal toxicity.
Pregnancy Category B. There have been no adequate and well-controlled studies of Amphotericin B in pregnant women. It is not known whether Amphotericin B is excreted in human milk.
As with any Amphoject-containing product the drug should be administered by medically trained personnel. During the initial dosing period, patients should be under close clinical observation. Amphoject has been shown to be significantly less toxic than Amphoject deoxycholate; however, adverse events may still occur.
Other Antifungal preparations
Aseptically add 12 mL of Sterile Water for Injection, to each Amphoject vial to yield a preparation containing 4 mg Amphoject/mL. Immediately after the addition of water, shake the vial vigorously for 30 seconds to completely disperse the Amphoject. This forms a yellow, translucent suspension. Visually inspect the vial for particulate matter and continue shaking until completely dispersed.
Unopened vials of lyophilized material are to be stored at temperatures up to 25°C. The reconstituted product concentrate may be stored for up to 24 hours at 2-8° C.
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