Generic Name: Paracetamol 125mg
Manufacturer/Distributor: Beximco Pharmaceuticals Ltd.
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Indications
Fever, common cold, influenza, headache, toothache, earache, body ache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum discomfort, inflammatory pain, and post-vaccination pain in children are among the conditions for which paracetamol is prescribed. It's also used to treat rheumatic and osteoarthritic pain, as well as joint stiffness.
Pharmacology
Paracetamol is an analgesic and antipyretic with just a little anti-inflammatory effect. Paracetamol (Acetaminophen) is considered to work largely in the central nervous system (CNS), raising the pain threshold by blocking both isoforms of the cyclooxygenase enzymes COX-1, COX-2, and COX-3, which are involved in prostaglandin (PG) production. Paracetamol is a para aminophenol derivative that possesses analgesic, antipyretic, and anti-inflammatory effects. One of the most commonly used, safest, and fastest-acting analgesics is paracetamol. It is well tolerated and devoid of aspirin's numerous adverse effects.
Dosage & Administration
Suppository:
Interaction
Barbiturates, tricyclic antidepressants, and alcohol may impair the capacity of patients to metabolize large doses of paracetamol. Overdosing paracetamol can cause hepatotoxicity if used with alcohol. Anticonvulsants and oral steroid contraceptives cause liver enzymes to increase, which may prevent therapeutic Paracetamol levels from being reached by increasing first-pass metabolism or clearance.
Contraindications
It is contraindicated in known hypersensitivity to Paracetamol.
Side Effects
Although hematological responses such as thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been described, paracetamol's side effects are typically moderate. Pancreatitis, rashes, and other allergic responses can happen at any time.
Pregnancy & Lactation
It is not recommended if you have a known hypersensitivity to paracetamol.
Precautions & Warnings
Storage Conditions
Keep below 30°C temperature in a dry place. Protected from light. Do not freeze. Keep out of reach of children.
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