Ace 500mg Tablet

Uses of Ace 500mg Tablet

• Fever
• Mild to Moderate pain
• Post Vaccination Fever

How does Ace 500mg Tablet work?

Ace 500mg Tablet decreases the intensity of pain signals in the brain. It also stops the release of prostaglandins, the chemical responsible for pain, and increases body temperature. Thus, this medicine provides relief from fever and mild to moderate pain.

Side Effects of Ace 500mg Tablet

• Stomach pain
• Dark colored urine
• Nausea and Vomiting
• Stomach pain
• Diarrhea
• Indigestion
• Skin Rash

Indication

Paracetamol is indicated in: 

• Fever, common cold, and influenza.
• Headache, toothache, earache, body ache, myalgia, dysmenorrhoea, neuralgia, and sprains.
• The pain of colic, back pain, post-operative pain, postpartum pain, chronic pain of cancer, inflammatory pain, post-vaccination pain and fever of children.
• Rheumatism and osteoarthritic pain & stiffness of joints in fingers, hips, knees, wrists, elbows, feet, ankles, and top & bottom of the spine.

Pharmacology

Paracetamol, also known as acetaminophen, is an analgesic (pain reliever) and antipyretic (fever reducer) medication. It is commonly used to relieve mild to moderate pain and reduce fever. Paracetamol is believed to exert its effects mainly in the central nervous system by increasing the pain threshold.

The exact mechanism of action of paracetamol is not fully understood, but it is thought to involve the inhibition of cyclooxygenase enzymes, specifically COX-1, COX-2, and COX-3. These enzymes are involved in the synthesis of prostaglandins, which are chemical messengers that contribute to the sensation of pain and the generation of fever. By inhibiting these enzymes, paracetamol reduces the production of prostaglandins, thereby providing pain relief and reducing fever.

It is important to note that while paracetamol has analgesic and antipyretic properties, its anti-inflammatory activity is weak compared to non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or aspirin. Paracetamol is generally considered safe and well-tolerated when used as directed. However, it is always important to follow the recommended dosage and consult a healthcare professional if you have any concerns or questions about its use.

Dosage & Administration of

The recommended dosage of the tablet form of paracetamol (acetaminophen) varies depending on the age and condition of the individual. Here are the general dosing guidelines:

For Adults: Take 1-2 tablets (500-1000 mg) every 4 to 6 hours as needed for pain or fever. However, the maximum daily dose should not exceed 4 grams (8 tablets).

For Children (6-12 years): Take ½ to 1 tablet (250-500 mg) 3 to 4 times daily as needed. It is important to follow the recommended dosage for children and consult a healthcare professional for appropriate dosing instructions based on the child's age and weight.

It is advisable not to exceed the maximum daily dose of 4 grams (8 tablets) for adults and 2.6 grams for children to avoid the risk of liver damage. If the symptoms persist or worsen, it is recommended to consult a healthcare professional.

When taking the tablet or capsule form of paracetamol, swallow it whole with a glass of water. It can be taken with or without food at any time. It should not be crushed, broken, or chewed unless specifically instructed by your healthcare provider. Following these instructions helps ensure the proper absorption and effectiveness of the medication.

Interaction

Drug-Drug Interactions: Ace 500mg Tablet may interact with various medications, including:

• Blood thinners (warfarin)
• Cholesterol-lowering drugs (cholestyramine)
• Analgesics (aspirin)
• Antibiotics (chloramphenicol, rifampicin)
• Anti-gout medicines (probenecid)
• Antitubercular drug (isoniazid)
• Anticonvulsants (lamotrigine, carbamazepine, phenytoin)
• Anti-nausea agents (metoclopramide, domperidone)

It is important to be cautious when using these medications together, and it may be necessary to adjust the doses or closely monitor for any potential interactions or side effects. It is advisable to consult a healthcare professional or pharmacist for more specific information based on individual circumstances.

Drug-Food Interactions: 

Ace 500mg Tablet may interact with St. John's wort, an herbal medicine used to treat depression. Additionally, it is recommended to avoid foods rich in carbohydrates and pectin, such as jellies, cabbage, Brussels sprouts, and broccoli, as they may interact with Ace 500mg Tablet. Alcohol consumption should also be avoided as it can increase the risk of liver damage when taken with Ace 500mg Tablet.

Drug-Disease Interactions: 

If you have kidney or liver disease, hepatitis, Gilbert's syndrome, hemolytic anemia, G-6-PD deficiency, or blood poisoning, it is important to inform your physician before taking Ace 500mg Tablet. These conditions may require special monitoring or adjustments in the dosage or frequency of Ace 500mg Tablet.

Please note that this information is not exhaustive, and it is always recommended to consult a healthcare professional or pharmacist for personalized advice regarding potential interactions with specific medications, foods, or medical conditions.

Contraindications

It is contraindicated in known hypersensitivity to Paracetamol.

Pregnancy & Lactation

Paracetamol (the active ingredient in Ace 500mg Tablet) is generally considered safe for use during pregnancy and is classified as pregnancy category B by the U.S. Food and Drug Administration (FDA). Pregnancy category B means that animal reproduction studies have not shown any risk to the fetus, but there are no well-controlled studies in pregnant women.

Paracetamol is commonly used to relieve pain and reduce fever during pregnancy when necessary. However, as with any medication, it is always recommended to consult with a healthcare professional or your doctor before taking any medications during pregnancy. They can provide specific guidance based on your individual circumstances and help weigh the benefits and potential risks of using paracetamol during pregnancy.

It's important to note that the safety of any medication during pregnancy should be determined by a healthcare professional, taking into account the potential benefits and risks for both the mother and the unborn baby.

Precautions & Warnings

• Allergy: Avoid taking Ace 500mg Tablet if you are allergic to it or have had a previous allergic reaction to it.
• Age restrictions: Ace 500mg Tablet is not recommended for children below 6 years of age. Use in pediatric patients should be based on the advice and guidance of a healthcare professional.
• Pregnancy and breast-feeding: If you are pregnant or breastfeeding, it is important to consult a physician before using Ace 500mg Tablet They can assess the potential risks and benefits for you and your baby.
• Alcohol consumption: Avoid consuming alcohol while taking Ace 500mg Tablet as it may increase the risk of liver damage.
• Impaired nutritional state or dehydration: Inform your doctor if you have an impaired nutritional state caused by anorexia, malnutrition, alcohol abuse, or if you are dehydrated. These conditions may require special consideration or monitoring when taking Ace 500mg Tablet.
• Dosage: It is important to follow the recommended dosage and avoid exceeding the recommended doses of Ace 500mg Tablet. Taking more than the recommended dose may increase the risk of serious liver damage.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.