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Barbit Elixir Syrup 50ml
Phenobarbital / Barbit Elixir belongs to a class of medicines called barbiturates. It is a prescription medicine used to treat and prevent epilepsy (seizures).
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✅ Description:
Indications
- Epilepsy: Treatment and prevention of seizures.
- Hypnotic: Reduces brain activity, causing drowsiness or tiredness.
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✔️ Pharmacology
- Mechanism: Suppresses sensory cortex, decreases motor activity, alters cerebellar function. Increases synaptic inhibition via GABAA receptors, raising seizure threshold and reducing seizure activity spread. Potentially inhibits calcium channels, decreasing excitatory transmitter release.
✔️ Dosage & Administration
Adults:
- Hypnosis: 100-320 mg
- Sedation: 30-120 mg/day in 2-3 doses
- Epilepsy: 60-250 mg/day
- Convulsions: 50-100 mg/day in 2-3 doses
- IV (Status epilepticus): 10-20 mg/kg, repeat as necessary
Children:
- Preoperative Sedation: 1-3 mg/kg
- Seizures: 4-6 mg/kg/day
- IV (Status epilepticus): 15-20 mg/kg over 10-15 minutes
✔️ Interactions
- Interacts with acetaminophen, anticoagulants, MAOIs, antidepressants, asthma, cold, allergy treatments, sedatives, steroids, tranquilizers, and vitamins. Increases drowsiness when combined with these drugs.
✔️ Contraindications
- Acute intermittent porphyria, barbiturate hypersensitivity.
✔️ Side Effects
- Common: Drowsiness.
- Others: CNS depression, agitation, psychiatric disturbances, bradycardia, apnea, nausea, constipation, restlessness, confusion in the elderly, and hyperkinesia in children.
✔️ Pregnancy & Lactation
- Category D: Potential fetal damage. May cause coagulation defects in newborns, preventable with Vitamin K.
- Excreted in breast milk; use caution.
✔️ Precautions & Warnings
- Potential for addiction with long-term use.
- Avoid use for more than two weeks for insomnia.
- Use caution in patients with depression, liver damage, suicidal thoughts, or a history of drug abuse.
✔️ Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.
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