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Tenaxit 0.5mg+10mg Tablet 1 Strip
Flupentixol and Melitracen tablets are indicated for the treatment of various depressive and anxiety-related conditions, including:
- Generalized anxiety and depressive disorders
- Apathy and lack of motivation
- Psychogenic depression
- Neurotic depression and masked depression
- Psychosomatic conditions associated with anxiety and apathy
- Menopausal mood disturbances
- Dysphoria and depression in individuals with a history of alcohol or drug abuse
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✅ Description:
This combination unites two clinically established agents:
- Flupentixol, a neuroleptic with intrinsic antidepressant and anti-anxiety activity in low doses
- Melitracen, a thymoleptic antidepressant with stimulating effects in mild to moderate depression
The synergistic effect results in improved mood, reduced anxiety, and increased motivation. Peak blood levels are typically achieved within 4 hours of oral dosing. The half-lives are approximately 35 hours for flupentixol and 19 hours for melitracen. No significant pharmacokinetic interactions occur between the two ingredients.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Each tablet contains:
- Flupentixol 0.5 mg – an antipsychotic with anxiolytic and mild antidepressant effects
- Melitracen 10 mg – a tricyclic antidepressant with energizing and mood-stabilizing properties
✔️ Dosage & Administration
Adults:
- Common dose: 2 tablets daily, one in the morning and one at noon
- Severe cases: May increase morning dose to 2 tablets
Elderly patients:
- Usually 1 tablet in the morning
Maintenance therapy:
- Typically 1 tablet daily in the morning
- In cases of insomnia or acute restlessness, an additional sedative may be prescribed during initial treatment.
✔️ Overdose Management
Symptoms of overdose typically reflect melitracen toxicity, including anticholinergic effects. Less frequently, extrapyramidal symptoms may result from flupentixol.
Management includes:
- Immediate gastric lavage
- Activated charcoal administration
- Supportive care for cardiovascular and respiratory functions
- Avoid epinephrine (adrenaline)
- Diazepam may be used to control convulsions
- Biperiden may be used to manage extrapyramidal reactions
✔️ Side Effects
- Side effects are uncommon at recommended doses. Some individuals may experience:
- Restlessness
- Difficulty sleeping (insomnia)
- These effects are usually mild and transient.
✔️ Words of Advice:
- This medicine treats depression and anxiety effectively
- Can cause drowsiness—avoid driving or hazardous tasks
- Do not consume alcohol during treatment
- Monitor blood sugar if you are diabetic
- Report any mood swings or unusual thoughts to your doctor
✔️ Drug Interactions
- May enhance the sedative effects of alcohol, barbiturates, and CNS depressants
- Concurrent use with MAO inhibitors can cause hypertensive crises; avoid co-administration or use within 14 days of MAOIs
- May reduce the efficacy of antihypertensive drugs such as guanethidine
- May potentiate the action of adrenaline or noradrenaline
✔️ Contraindications
- Recent myocardial infarction recovery phase
- Cardiac conduction abnormalities (e.g., bundle-branch block)
- Untreated narrow-angle glaucoma
- Acute intoxication from alcohol, opioids, or barbiturates
- Use of MAO inhibitors within the past two weeks
- Not suitable for hyperactive or excitable patients due to its activating effects
✔️ Use in Pregnancy & Lactation
- This medication is not recommended during pregnancy or breastfeeding due to insufficient safety data. Use only if the potential benefit justifies the risk.
- Precautions & Warnings
- Discontinue other sedative medications gradually if switching to this therapy
- Monitor closely for signs of mood changes or suicidal ideation, particularly at treatment initiation
- Caution advised in patients with liver impairment, cardiovascular disease, glaucoma, urinary retention, or thyroid dysfunction
✔️ Storage Conditions
- Store below 30°C in a dry place
- Protect from direct light
- Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
