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Recodep 12.5mg/5mg Tablet 1 Strip
Recodep is prescribed for the treatment of moderate to severe depression accompanied by moderate to severe anxiety. The symptoms that may respond within the first week of treatment include insomnia, feelings of guilt or worthlessness, agitation, both psychic and somatic anxiety, suicidal thoughts, and loss of appetite.
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✅ Description:
Recodep contains Amitriptyline, a tricyclic antidepressant, and Chlordiazepoxide, an anxiolytic.
- Amitriptyline works by inhibiting the reuptake of norepinephrine and serotonin in the brain, which contributes to its antidepressant effect.
- Chlordiazepoxide enhances the effect of GABA (gamma-aminobutyric acid) by increasing chloride influx through GABA receptor channels, leading to membrane hyperpolarization and resulting in sedative and anxiolytic effects.
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✔️ Side Effects
Common side effects related to depression symptoms include anorexia, fatigue, weakness, restlessness, and lethargy. More specific side effects reported include:
- Frequent: drowsiness, dry mouth, constipation, blurred vision, dizziness, and bloating.
- Less frequent: vivid dreams, impotence, tremors, confusion, and nasal congestion.
✔️ Dosage & Administration
The optimal dose depends on the severity of the symptoms and the patient’s response. Once a satisfactory response is achieved, the dosage should be reduced to the minimum required to maintain remission. The majority of the total daily dose is usually taken at bedtime. For some patients, a single bedtime dose may be sufficient. A typical starting dosage is 3 to 4 tablets per day, divided into doses, or as directed by a physician.
✔️ Interactions
Due to the Amitriptyline component, Recodep may reduce the antihypertensive effects of guanethidine or similar medications.
✔️ Contraindications
Recodep should not be used by individuals who are hypersensitive to benzodiazepines or tricyclic antidepressants. It is also contraindicated for patients taking monoamine oxidase inhibitors (MAOIs).
✔️ Pediatric Use:
- Safety and effectiveness in children and adolescents have not been established. The risks and benefits must be carefully weighed when considering use in this population.
✔️ Geriatric Use:
For elderly and debilitated patients, the dosage should be limited to the lowest effective amount to avoid the risks of ataxia, excessive sedation, confusion, and anticholinergic effects.
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Overdose Effects
Overdosing on Recodep can be fatal. Amitriptyline overdose may result in severe manifestations such as cardiac arrhythmias, hypotension, convulsions, and CNS depression, including coma. Benzodiazepine overdose can cause somnolence, confusion, coma, and reduced reflexes.
Withdrawal symptoms may occur if Chlordiazepoxide or Amitriptyline is abruptly discontinued, including convulsions, tremors, muscle cramps, vomiting, and sweating. Milder withdrawal symptoms like dysphoria and insomnia can occur with abrupt cessation of benzodiazepines used continuously for several months. Amitriptyline withdrawal can cause symptoms like nausea, headache, and malaise.
✔️ Pregnancy & Lactation
The safety of Recodep during pregnancy and lactation has not been established.
✔️ Precautions & Warnings
- Use with caution in patients with a history of seizures.
- Close monitoring is required for hyperthyroid patients or those on thyroid medication.
- Use cautiously in patients with renal or hepatic impairment.
- Pediatric patients on antidepressants should be closely monitored for clinical worsening, suicidality, and unusual changes in behavior.
✔️ Storage Conditions
Store in a cool, dry place, away from light. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
