Dextrim Syrup 100ml

Uses of Dextrim Syrup

• Dry Cough
• Allergies

How does Dextrim Syrup work?

Dextromethorphan is a cough suppressant that acts by blocking the transmission of nerve signals from the cough center in the brain to the muscles responsible for producing cough. This helps to decrease the urge to cough.

Triprolidine is an antihistamine that works by blocking the action of histamine, a substance involved in allergic reactions. By inhibiting histamine, triprolidine provides relief from allergy symptoms such as sneezing, runny nose, watery eyes, itching, swelling, and congestion or stuffiness.

Phenylephrine is a decongestant that works by constricting and narrowing the blood vessels in the nasal passages and airways. This action helps to relieve congestion or stuffiness in the nose, allowing for improved breathing.

Together, these three drugs in Dextromethorphan+Triprolidine+Phenylephrine provide a combined effect of suppressing cough, relieving allergy symptoms, and alleviating nasal congestion or stuffiness.

Side Effects of Dextrim Syrup

• Drowsiness
• Dizziness
• Stomach upset
• Difficulty in sleeping
• Nervousness and excitable

Quick Suggestions:

• Avoiding dairy products, processed or refined foods, and citrus fruits, as well as consuming plenty of fluids and eating fruits rich in water content, can be helpful for some individuals in managing cough symptoms.
• However, these recommendations may vary depending on the underlying cause of the cough and individual sensitivities. It's always a good idea to consult with a healthcare professional for personalized advice and treatment options.
• Regarding the special advice to consult a doctor if the cough persists or worsens after 1 week of treatment with Dextromethorphan+Triprolidine+Phenylephrine, it is a prudent recommendation. If cough symptoms persist or worsen despite using the medication, it is important to seek further medical evaluation to determine the underlying cause and explore alternative treatment options if necessary.
• It's worth noting that the information provided here is not a substitute for professional medical advice. Always consult with a healthcare professional for proper diagnosis and guidance regarding your specific condition.

Indication

Dextromethorphan 20/5mg/ml + Phenylephrine 10/5mg/ml + Triprolidine 2.5/5mg/ml provides temporary relief for various symptoms associated with upper respiratory tract disorders. These symptoms may include a non-productive cough, runny nose, sneezing, itching of the nose or throat, itchy and watery eyes, nasal congestion, and swelling of nasal passages. The medication can be used to alleviate these symptoms caused by conditions such as the common cold, hay fever (allergic rhinitis), other upper respiratory allergies, as well as cough due to minor throat or bronchial irritation.

It's important to note that this medication does not cure the underlying condition causing these symptoms, but it can help provide relief from them on a temporary basis. If the symptoms persist or worsen, it is advisable to consult a healthcare professional for further evaluation and appropriate treatment.

Pharmacology

Dextromethorphan is a non-narcotic antitussive drug that acts centrally on the cough center in the medulla. It helps to suppress coughing by blocking nerve signals responsible for triggering cough reflexes. Unlike morphine, it does not have analgesic (pain-relieving) effects or habit-forming properties. It also tends to have minimal sedative (sleep-inducing) actions.

Phenylephrine, a decongestant, works by constricting blood vessels in the nasal passages. This action helps to alleviate nasal and sinus congestion by reducing the swelling and allowing for easier breathing. It can also provide relief for congested tubes that drain fluid from the inner ear.

Triprolidine is an antihistamine that offers symptomatic relief for conditions believed to be caused wholly or partly by the release of histamine. Histamine is a substance released during allergic reactions and can cause symptoms such as sneezing, runny nose, watery eyes, and throat irritation. By blocking the action of histamine, triprolidine helps to relieve these allergic symptoms.

These three components together in Dextromethorphan+Triprolidine+Phenylephrine provide a combination of cough suppression, nasal/sinus congestion relief, and alleviation of allergic symptoms.

Dosage & Administration of Dextrim Syrup

• Adults & Children 12 years of age and older: 1 teaspoonful (5 ml) every 4 hours.
• Children 6 to under 12 years of age: ½ teaspoonful (2.5 ml) every 4 hours. (Note: Not to be used in children below 2 years old.)
• Children 2 to 6 years of age: To be used with caution and as advised by the physician. (Physician's advice should be obtained before administering this combination to children less than 6 years.)
• Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Interaction

1. Drug-Drug Interactions:

• Anti-allergic drugs (diphenhydramine, chlorpheniramine, promethazine): There may be potential interactions between Dextromethorphan+Triprolidine+Phenylephrine and these medications. It's important to consult your doctor or healthcare professional before combining them.
• Narcotic analgesics (hydrocodone, codeine, morphine): There may be interactions between Dextromethorphan+Triprolidine+Phenylephrine and narcotic analgesics. It is advisable to seek medical advice before using them together.
• Central nervous system stimulants (methylphenidate): Interactions may occur between Dextromethorphan+Triprolidine+Phenylephrine and central nervous system stimulants. Consult your doctor for guidance on combining these medications.
• Antidepressants (duloxetine, sertraline, escitalopram): Potential interactions may exist between Dextromethorphan+Triprolidine+Phenylephrine and certain antidepressants. It is important to seek medical advice before combining them.
• Bronchodilators (tiotropium): Interactions between Dextromethorphan+Triprolidine+Phenylephrine and bronchodilators may occur. Consult your doctor for guidance on combining these medications.
• Medicines used to treat irregular heartbeats (quinidine): There may be potential interactions between Dextromethorphan+Triprolidine+Phenylephrine and quinidine. It is advisable to seek medical advice before using them together.
• Anticonvulsants (pregabalin): Interactions may occur between Dextromethorphan+Triprolidine+Phenylephrine and anticonvulsant medications such as pregabalin. Consult your doctor for guidance on combining these medications.
• Antianxiety drug (alprazolam): Potential interactions may exist between Dextromethorphan+Triprolidine+Phenylephrine and antianxiety medications like alprazolam. It is important to seek medical advice before combining them.
• Antipsychotics (quetiapine): Interactions between Dextromethorphan+Triprolidine+Phenylephrine and antipsychotic medications such as quetiapine may occur. Consult your doctor for guidance on combining these medications.

1. Drug-Food Interaction:

• Chocolate and caffeine-containing foods: It is advised to avoid or limit the intake of chocolate and caffeine-containing foods, such as cocoa beans and tea leaves, as they may increase the risk of severity of side effects when used with Dextromethorphan+Triprolidine+Phenylephrine.
• Alcohol: Avoid consuming alcohol while taking Dextromethorphan+Triprolidine+Phenylephrine as it may increase the risk of adverse effects such as drowsiness, dizziness, or difficulty in concentrating.
• Grapefruit juice: It is recommended to avoid drinking grapefruit juice or eating grapefruit as it can lead to excessive accumulation of the drugs in Dextromethorphan+Triprolidine+Phenylephrine, potentially increasing their effects.

1. Drug-Disease Interaction:

• Asthma, emphysema, cough with excessive mucus, or cough caused by smoking: Inform your doctor about these conditions before taking Dextromethorphan

Contraindications

This combination is contraindicated in individuals who have a known hypersensitivity to Dextromethorphan, Phenylephrine, or Triprolidine, as well as in those who have recently stopped using a Monoamine Oxidase Inhibitor.

Pregnancy & Lactation

There is no particular evidence on the usage of this combination during pregnancy and lactation.

Precautions & Warnings

• Allergies: If you are allergic to Dextrim Syrup (Dextromethorphan+Triprolidine+Phenylephrine) or any other medicines, it's important to inform your doctor.
• Pregnancy and breastfeeding: If you are pregnant or breastfeeding, it is advised to consult your doctor before using Dextromethorphan+Triprolidine+Phenylephrine. They can provide guidance on the safety and potential risks during pregnancy or breastfeeding.
• Use in children: Dextromethorphan+Triprolidine+Phenylephrine should be used with caution in children. It's advisable to follow the guidance of a healthcare professional regarding the appropriate use and dosage in children.
• Interaction with certain medications: Avoid using Dextrim Syrup if you have taken medicines for Parkinson's disease or antidepressants such as phenelzine, selegiline, rasagiline, isocarboxazid, and tranylcypromine in the past 14 days. These medications can interact with Dextromethorphan+Triprolidine+Phenylephrine and cause adverse effects.
• Caffeine intake: It is advised to avoid caffeine intake while using Dextromethorphan+Triprolidine+Phenylephrine, as it may increase the risk and severity of adverse effects.
• Pre-existing conditions: If you have asthma, emphysema, a cough with excessive mucus, or a cough caused by smoking, inform your doctor before taking Dextromethorphan+Triprolidine+Phenylephrine. They can evaluate your condition and determine if this medication is suitable for you.
• Grapefruit juice interaction: Caution is advised when consuming grapefruit juice or eating grapefruit while using Dextromethorphan+Triprolidine+Phenylephrine. Grapefruit can interfere with the metabolism of certain medications, leading to increased and prolonged effects.

Storage Conditions

Keep away from direct sunlight and keep in a cool, dry location. Keep out of children's reach.