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Coughex 45mg Tablet 1 Strip
Coughex is used for the treatment of:
- Refractory chronic cough (persistent cough unresponsive to treatment).
- Unexplained chronic cough in adults.
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✅ Description:
- Gefapixant is a P2X3 receptor antagonist.
- Mechanism of action:
- P2X3 receptors are found in sensory C-fibers of the vagus nerve.
- Inflammation releases ATP, which binds to P2X3 receptors, triggering a cough reflex.
- Gefapixant blocks ATP-mediated activation, reducing chronic cough.
✔️ Dosage & Administration
- Adults: 45 mg tablet twice daily (with or without food).
- Missed dose: Skip the missed dose and take the next scheduled dose.
- Elderly: No dose adjustment required, but caution is advised due to potential renal impairment.
- Pediatric patients (<18 years): Safety and efficacy not established.
- Obstructive sleep apnea: Not recommended for patients with this condition.
- Liver disease: Not studied in hepatic impairment.
- Renal impairment:
- Severe impairment (eGFR <30 mL/min/1.73m², non-dialysis): 45 mg once daily.
- Mild to moderate impairment: No dose adjustment required.
🔹 Dizziness may occur – caution when driving or operating machines.
✔️ Side Effects
- Taste disturbances (dysgeusia, ageusia, hypogeusia).
- Upper respiratory infections.
- Reduced appetite.
- Dizziness, nausea, diarrhea, dry mouth, hypersalivation.
- Epigastric pain, dyspepsia, oral numbness (hypoesthesia), tingling (paresthesia).
✔️ Drug Interactions
- Proton pump inhibitors (e.g., Omeprazole): No significant interaction.
- CYP inhibition/induction potential: Low.
- No major drug interactions were identified.
✔️ Contraindications
Severe hypersensitivity reaction to Gefapixant or any ingredient.
✔️ Use in Pregnancy & Lactation
- Not recommended in pregnancy due to lack of data.
- Unknown if excreted in breast milk—avoid during breastfeeding.
- Fertility effects: No known impairment in humans, but animal studies show no adverse impact.
✔️ Precautions & Warnings
- Caution in patients with sulfonamide hypersensitivity.
- Do not discontinue without consulting a doctor.
✔️ Storage Conditions
- Store below 30°C in a cool, dry place.
- Keep away from light and out of children's reach.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
