Generic Name: Enoxaparin 40mg/0.4ml
Manufacturer/Distributor: Drug International Ltd.
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Indications of Cardinex-40 IV SC Injection
Treatment of deep vein thrombosis with or without pulmonary embolism with enoxaparin.
Concurrently administered aspirin for the treatment of unstable angina and non-Q-wave myocardial infarction.
During haemodialysis, thrombus development in the extracorporal circulation is avoided.
Prophylaxis for venous thromboembolic illness (the prevention of blood clots in the veins), particularly in cases when orthopedic or general surgery is involved.
Thromboembolic disease prevention in medical patients who are bedridden owing to an acute illness, such as heart insufficiency, respiratory failure, severe infections, or rheumatic disorders.
Pharmacology of Cardinex-40 IV SC Injection
Enoxaparin Sodium is a heparin with a low molecular weight that has a significant anti-Xa activity but a poor anti-lla or antithrombin activity. Enoxaparin Sodium does not enhance bleeding time at the levels recommended for the various purposes. Enoxaparin Sodium has no effect on the activated partial thromboplastin time at preventative dosages (aPTT). It has no effect on platelet aggregation or fibrinogen binding to platelets. Enoxaparin Sodium is metabolized mostly in the liver.
Dosage & Administration of Cardinex-40 IV SC Injection
Prophylaxis of venous thromboembolic disease in surgical patients:
Interaction of Cardinex-40 IV SC Injection
Unless strictly necessary, medications that impair hemostasis should be stopped prior to starting Enoxaparin Sodium therapy. Other antiplatelet aggregation agents include glycoprotein llb/llla antagonists, acetylsalicylic acid (and derivatives), NSAIDs (including ketorolac), ticlopidine,clopidogrel,dextran 40,glucocorticoids, thrombolytics and anticoagulants, and thrombolytics and anticoagulants. If the combination is appropriate, it should be used under close clinical and laboratory supervision.
Contraindications
Patients who have previously been allergic to Enoxaparin Sodium, heparin, or other low molecular weight heparins. Active severe bleeding and circumstances that increase the likelihood of uncontrolled hemorrhage, such as recent hemorrhagic stroke.
Side Effects of Cardinex-40 IV SC Injection
Thrombocytopenia, haemorrhage (bleeding), and serum aminotransferase increases. Pain, bluish markings, and skin rash at injection sites are all common side effects. Neurologic damage have been reported in cases of neuraxial hematomas caused by the use of Enoxaparin and spinal/epidural anesthesia or spinal puncture.
Pregnancy & Lactation
Category B pregnancy. Enoxaparin Sodium does not appear to penetrate the placental barrier in humans. Enoxaparin Sodium should only be taken during pregnancy if obviously needed, as there are no good and well-controlled studies in pregnant women. Thromboembolism may be more common in pregnant women who have mechanical prosthetic heart valves.
Enoxaparin is not known to be eliminated in human milk. Because many medicines are excreted in human milk and there is a risk of serious adverse reactions in nursing infants, it is important to consider whether to stop nursing or stop taking Enoxaparin, taking into account the value of Enoxaparin to the mother and the known benefits of breastfeeding.
Precautions & Warnings
In preventative and curative treatment, Enoxaparin Sodium should be injected deep subcutaneously, and during hemodialysis, it should be given intravascularly. The intramuscular route should not be used. In conditions where there is a higher risk of bleeding, such as impaired hemostasis, a history of peptic ulcer, recent ischemic stroke, uncontrolled severe arterial hypertension, diabetic retinopathy, and recent neuro- or ophthalmologic surgery, and concomitant use of medications that affect hemostasis, Enoxaparin Sodium should be used with caution. Platelet counts should be checked before starting treatment and then on a frequent basis after that.
Storage Conditions
Protect from light and moisture by storing in a cool, dry location. Store at a temperature of no more than 25°C. Do not keep in the fridge or freezer. Keep out of children's reach.
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