Class: Selective Leukotriene Receptor Antagonist
Montelukast specifically blocks CysLT1 receptors, preventing the action of leukotrienes (LTC4, LTD4, LTE4).
This inhibition reduces airway edema, smooth muscle contraction, and inflammatory cell activation.
Clinical benefit: improves asthma control and relieves allergic rhinitis symptoms.
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Asthma is a chronic inflammatory disease of the lungs and airways. It occurs when the air passages become overly sensitive to triggers such as viruses, allergens, or exercise. This results in airway narrowing, leading to symptoms like:
Asthmatic attacks are linked to the release of chemicals in the lungs called leukotrienes, which play a key role in airway inflammation and obstruction.
An allergy is an immune system reaction to normally harmless substances, called allergens. Allergic responses differ among individuals and may include sensitivity to:
Common symptoms include coughing, which happens as the body’s reflex to clear mucus or irritants from the throat, along with sneezing, a runny nose, or itchy eyes.
Avoid drinking alcohol while taking Montelukast, as it can worsen your side effects, such as drowsiness.
There is limited data on how Montelukast affects pregnancy. Please consult your doctor if you are planning to conceive or are already pregnant before starting Montelukast.
There is limited data on how Montelukast affects breastfeeding. However, Montelukast may pass into breast milk. Please consult your doctor before starting Montelukast.
Do not drive or operate machinery if you experience drowsiness or difficulty in concentrating while using Montelukast. Montelukast may affect your ability to drive. Seek medical attention if the symptoms persist longer.
Inform your doctor if you have a history of kidney disease.
Inform your doctor if you have a history of liver disease.
Long-term management and prevention of asthma.
Acute prevention of Exercise-Induced Bronchoconstriction (EIB).
Relief of symptoms of allergic rhinitis (both seasonal & perennial).
Adults & Adolescents (≥15 years): 10 mg once daily.
Children 6–14 years: 5 mg once daily.
Children 2–5 years: 4 mg once daily (chewable tablet).
Children 6 months–5 years: 4 mg oral granules once daily (directly or mixed with cold water/soft food).
Elderly, renal impairment, mild-moderate hepatic impairment: No dose adjustment needed.
Generally safe with commonly used asthma therapies and drugs such as theophylline, steroids, digoxin, warfarin, and oral contraceptives.
Phenobarbital & rifampin: Reduce plasma levels (~40%) due to hepatic enzyme induction → monitor clinically.
No major interactions reported with thyroid hormones, NSAIDs, benzodiazepines, decongestants, etc.
Hypersensitivity to Montelukast or any component of the formulation.
Not for acute asthma attacks or status asthmaticus → patients must carry a rescue inhaler.
Can be continued during asthma exacerbations but should not replace corticosteroids abruptly.
Not to be used as sole therapy for exercise-induced bronchospasm.
Patients with aspirin-sensitive asthma must still avoid aspirin/NSAIDs.
Caution in pregnancy & lactation—use only if clearly needed.
Store below 30°C, in a cool, dry place away from moisture and light.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.