Catium Trio 80 Convicap 1 Strip

✔️ Pharmacology – How Catium Trio Works?

💨 Indacaterol (Ultra-LABA)

• A long-acting beta-2 adrenergic receptor agonist that promotes bronchodilation by increasing intracellular cyclic AMP (cAMP) levels.
• Rapid onset of action and long-lasting effects ensure sustained airway relaxation.
• While primarily targeting beta-2 receptors in the lungs, it also has minimal interaction with beta-1 and beta-3 receptors, reducing cardiovascular side effects.

💨 Glycopyrronium (Ultra-LAMA)

• A muscarinic receptor antagonist that blocks bronchoconstriction by preventing acetylcholine from acting on airway smooth muscles.
• Highly selective for M1 and M3 receptors, ensuring effective airway relaxation with minimal M2 receptor interaction.
• Rapid absorption and long duration allow for once-daily dosing.

💨 Mometasone Furoate (ICS - Inhaled Corticosteroid)

• A potent glucocorticoid receptor agonist with strong anti-inflammatory effects.
• Suppresses pro-inflammatory cytokines, including IL-1, IL-5, IL-6, and TNF-alpha, which contribute to airway inflammation.
• Reduces the release of leukotrienes, helping to control asthma-related allergic responses.

✔️ Why Choose Catium Trio for Asthma Management?

✅ Triple-action therapy: Relieves airway constriction, reduces inflammation and prevents asthma flare-ups.
✅ Once-daily dosing: Ensures convenient and effective long-term control.
✅ Clinically tested ingredients: Backed by research for improved lung function and symptom relief.

✔️ Dosage & Administration

✔ For inhalation use only with the prescribed inhalation device.
✔ One capsule per day – do not exceed the recommended dose.
✔ Remove the capsule just before use and inhale the full dose through the inhaler.
✔ Not intended for oral ingestion.

✔️ Use with caution in patients taking:

• Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants – may prolong the QT interval.
• Methylxanthine derivatives, steroids, or non-potassium-sparing diuretics – may increase the risk of hypokalemia.
• Beta-blockers (ß2-adrenergic blockers) – should not be used together with Catium Trio, as they may counteract its therapeutic effects.

✔️ Potential Side Effects

🔹 Most common adverse reactions reported over 52 weeks of use include:
✔ Nasopharyngitis (common cold symptoms)
✔ Upper respiratory tract infections
✔ Headaches

✔️ Contraindications

❌ Do not use Catium Trio if you have a known hypersensitivity to any of its active ingredients or excipients.

✔️ Use in Pregnancy & Lactation

🤰 Pregnancy: Limited data is available. Animal studies suggest potential fetal risk, so use only if the benefits outweigh potential harm.
🤱 Breastfeeding: The presence of the drug in human milk is unknown, but similar corticosteroids have been found in breast milk. Use with caution under medical advice.

✔️ Precautions & Warnings

✔ Not for acute asthma attacks – This is a maintenance therapy, not a rescue inhaler.
✔ Monitor cardiovascular effects – It may increase heart rate or blood pressure in some patients.
✔ Diabetes caution – May cause elevated blood sugar levels, requiring closer plasma glucose monitoring.
✔ Oral hygiene recommendation – Rinse your mouth with water (without swallowing) or brush your teeth after inhalation to prevent oral fungal infections (oropharyngeal candidiasis).
✔ Proper usage – Do not swallow capsules; they should only be used with the inhaler device.

✔️ Storage Instructions

✔ Store below 30°C, away from light and moisture.
✔ Keep out of reach of children.