Brezofil SR 400 Tablet 1 Strip

✔️ Brezofil is indicated for the management of:

Bronchial asthma

Bronchospasm

Chronic obstructive pulmonary disease (COPD)

Pulmonary disorders associated with bronchial spasm

✔️ Words of Advice:

• Regular blood tests are recommended while taking Doxofylline to monitor potassium levels and levels of Doxofylline in the blood.
• Doxofylline can cause serious side effects, possibly similar to those that occur when taking too much amount of caffeine. Avoid consuming Doxofylline with caffeinated beverages, such as chocolate and coffee.

✔️ Dosage & Administration

Elderly:

200 mg tablet, two or three times daily

Adults:

400 mg tablet, two or three times daily, or as directed by the physician

Children:

Above 12 years: 10 ml syrup or 200 mg tablet, two or three times daily

6–12 years: 6–9 mg/kg body weight, twice daily

Example: For a child weighing 10 kg, 3 ml (60 mg) twice daily

If the total daily requirement is 400 mg, a Doxophylline sustained-release (SR) tablet may be administered once daily, preferably as prescribed by the physician.

✔️ Interaction

Drug-Drug Interaction: Doxofylline may interact with medicines used to treat gout (allopurinol), antacids (cimetidine), antibiotics (erythromycin, clindamycin, lincomycin), drugs used to lower high blood pressure (propranolol), central nervous system stimulants (ephedrine), flu vaccines (influenza vaccines), and anticonvulsants (phenytoin).

Drug-Food Interaction: Doxofylline may interact with caffeine. Therefore, avoid consuming Doxofylline with chocolate and caffeine-containing foods, such as cocoa beans and tea leaves, as they may increase the risk of severe side effects.

Drug-Disease Interaction: If you have low blood pressure, congestive heart failure, hypoxemia (low oxygen levels in the blood), hyperthyroidism (an overactive thyroid), pulmonary heart disease, stomach ulcers, kidney, liver, or heart disease, inform your doctor before taking Doxofylline.

✔️ Pregnancy & Lactation

Animal studies indicate that doxophylline does not adversely affect pre- or postnatal development. However, due to limited clinical data in pregnant women, use during pregnancy should be carefully considered based on the risk-benefit ratio.
The drug is contraindicated during lactation.

✔️ Brezofil is contraindicated in patients with:

• Known hypersensitivity to doxophylline or other xanthine derivatives
• Acute myocardial infarction
• Hypotension
• Lactation

In cases of overdose, severe cardiac arrhythmias and tonic-clonic seizures may occur and may represent early signs of toxicity. If adverse effects appear, treatment may need to be discontinued and restarted at a lower dose after symptoms resolve, based on the physician's discretion.

✔️ Safety Information:

If you are allergic to Brezofil SR 400 or any other medicines, please tell your doctor. You are recommended to avoid taking Doxofylline with chocolate and caffeinated foods, such as cocoa beans or tea leaves, as they may increase the risk of severe side effects. Doxofylline is contraindicated in breastfeeding mothers. If you are pregnant or planning a pregnancy, please consult a doctor before using Doxofylline. Do not take Doxofylline if you have low blood pressure or have had a heart attack. Brezofil SR 400 should be used with caution in congestive heart failure patients, as these patients have slow drug clearance, leading to high blood levels even after stopping treatment with Doxofylline. If you have low blood pressure, congestive heart failure, hypoxemia (low oxygen levels in the blood), hyperthyroidism (overactive thyroid), pulmonary heart diseases, stomach ulcer, kidney, liver, or heart diseases, inform your doctor before taking Doxofylline. Doxofylline is not recommended for children under 6 years of age, as its safety and efficacy have not been fully established.

✔️ Storage:

Store in a dry place, protected from light and heat.
Keep out of reach of children.