Disopan | Clonazepam 1mg/ml Injection | Price | ePharma
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Disopan 1mg/ml Injection

Generic: Clonazepam

Type: Injection

Pack Size: 1 Pc

Clonazepam 1mg/ml is a prescription medicine used to treat anxiety disorder and epilepsy (seizures). It works by suppressing the abnormal and excessive activity of the nerve cells in the brain.

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Discount Price: ৳ 143
MRP: ৳ 150 5% Off

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✅ Description:

Disopan 1mg/ml Injection is a formulation of clonazepam, a benzodiazepine derivative primarily used for its anticonvulsant and anxiolytic properties. 

  • Treatment of panic disorder with or without agoraphobia.
  • Adjunctive therapy in Lennox-Gastaut Syndrome (petit mal variant), akinetic, myoclonic seizures, and absence seizures refractory to succinimides.
  • Acts by enhancing GABAergic neurotransmission, leading to increased GABA receptor affinity and subsequent enhanced chloride ion influx, exerting anticonvulsant, sedative, muscle relaxant, and anxiolytic effects.
  • For acute conditions in adults, administer 1 mg slowly by IV injection, repeated if necessary, with careful monitoring (maximum total dose 10 mg).

No significant alteration in the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital was noted. Hypersensitivity to benzodiazepines, acute narrow-angle glaucoma, significant liver disease. Monitor for increased seizure activity in mixed seizure disorders. Enhanced pharmacologic effects in geriatric patients; caution in hepatic impairment.

Safety Advices


Alcohol
UNSAFE

Do not consume alcohol after receiving Disopan 1mg/ml Injection as it may provoke seizures and may worsen side effects.


Pregnancy
UNSAFE

Disopan 1mg/ml Injection is generally not recommended for use in pregnant women unless considered necessary. Consult your doctor before receiving it.


Breastfeeding
UNSAFE

Disopan 1mg/ml Injection is generally not recommended for use in breastfeeding women as it passes through the breast milk. Consult your doctor before receiving it.


Driving
CAUTION

Disopan 1mg/ml Injection can cause dizziness, drowsiness, and decreased alertness. Do not drive or operate any machines after administration of Disopan 1mg/ml Injection.


Kidney
CONSULT YOUR DOCTOR

Disopan 1mg/ml Injection should be used with caution in patients with kidney disease. Consult your doctor before receiving it.


Liver
CONSULT YOUR DOCTOR

Disopan 1mg/ml Injection is not recommended for use in patients with severe liver disease. Consult your doctor before receiving it.

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Relevant Products / প্রাসঙ্গিক পণ্য

✔️ Uses of Disopan 1mg/ml Injection
  • Treatment of Anxiety disorder
  • Treatment of Epilepsy/Seizures
✔️ How does Disopan 1mg/ml Injection work?

It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.

✔️ Side Effects of Disopan 1mg/ml Injection
  • Common CNS depressant effects include drowsiness, ataxia, behavior changes, and eye movement abnormalities.
  • Less frequent: coma, tremor, vertigo, confusion, depression, hallucinations, insomnia, psychosis, palpitations.
✔️ Quick Suggestions:
  • The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor
  • It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
  • Avoid consuming alcohol as it may increase dizziness and drowsiness.
  • Inform your doctor if you experience worsened anxiety, depression anger, or violent behavior and mania while taking this medicine.
  • Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremors, and confusion.
✔️ Disopan (Clonazepam) is indicated for the treatment of:
  • Panic disorder, with or without agoraphobia, is characterized by unexpected panic attacks and associated concerns.
  • Lennox-Gastaut Syndrome (petit mal variant), akinetic and myoclonic seizures.
  • Absence of seizures (petit mal) in patients who have not responded to succinimides.
✔️ Pharmacology
  • Clonazepam, a benzodiazepine, enhances GABAergic neurotransmission, leading to increased GABA receptor affinity and enhanced postsynaptic chloride ion flux.
  • Animal and human data indicate clonazepam's rapid suppression of various seizure types, including spike-and-wave discharges.
✔️ Dosage of Disopan 1mg/ml Injection

Injection:

  • Children: Administer 0.5 mg (half vial) slowly by IV injection or infusion.
  • Adults: Administer 1 mg (full vial) slowly by IV; repeat dose as needed, up to 10 mg total, with caution on injection rate (0.25-0.5 mg/min).
✔️ Administration of Disopan 1mg/ml Injection

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

✔️ Overdose Effects of Disopan 1mg/ml Injection
  • Symptoms include severe CNS depression, respiratory depression, and coma.
  • Manage with supportive measures; consider activated charcoal and use flumazenil cautiously.
✔️ Interaction

No significant alteration of phenytoin, carbamazepine, or phenobarbital pharmacokinetics was noted with Disopan.

✔️ Contraindications

Hypersensitivity to benzodiazepines, acute narrow-angle glaucoma, significant liver disease.

✔️ Pregnancy & Lactation
  • Avoid during pregnancy unless the benefits outweigh the risks; may cause fetal abnormalities.
  • Discontinue breastfeeding during treatment due to small amounts excreted in breast milk.
✔️ Precautions & Warnings
  • Monitor for increased seizure activity in certain seizure disorders.
  • Geriatric patients may experience enhanced pharmacologic effects.
  • No dosage adjustment is necessary for renal impairment; caution in hepatic impairment.
✔️ Storage Conditions:
  • Keep Disopan in a dry place away from light and heat.
  • Ensure it is stored out of the reach of children.
✔️ Before Reconstitution:
  • Disopan is typically provided in vials for intravenous administration.
  • Store the vials at room temperature (approximately 20°C to 25°C or 68°F to 77°F) unless otherwise specified by the manufacturer.
✔️ Reconstitution and Administration:
  • For slow intravenous injection, each vial of Disopan (1 mg) should be diluted with 1 mL of water for injection before administration to prevent local irritation of the veins.
  • For intravenous infusion, Disopan can be diluted in a ratio of 1 vial (1 mg) to at least 85 mL of diluting media (e.g., sodium chloride 0.9%, glucose 5%). Use infusion bags other than PVC if possible. If PVC bags are used, infuse immediately or within 4 hours.
  • Intramuscular injection should only be used in exceptional cases or when intravenous administration is not feasible.
✔️ Specific Storage Conditions Post-Reconstitution:
  • After reconstitution, follow specific guidelines based on the type of administration:
    • For intravenous infusion, the diluted solution is stable for 24 hours at room temperature.
    • If using PVC bags, infuse immediately or within 4 hours.
    • Do not use sodium bicarbonate solution for preparing Disopan infusions due to potential precipitation.
Frequently Asked Questions (FAQ)

No

Disopan 1mg/ml Injection will be given to you only by a doctor or a nurse into a vein. Your doctor will administer the correct dose and duration of management for you depending upon your age, body weight and disease condition.
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⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
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