Disopan 2mg | Tablet | Clonazepam | Uses, Dosage, Price | ePharma
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Disopan 2mg Tablet

Generic: Clonazepam

Type: Tablet

Pack Size: 10 Pcs

A prescription drug called Disopan 2 is used to treat panic and anxiety disorders, as well as epilepsy (seizures). It helps to calm the brain and lessen abnormal and excessive nerve cell activity.


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Discount Price: ৳ 116.25
MRP: ৳ 125 7% Off

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Description:

  • Disopan 2 Tablet is a benzodiazepine medicine that is primarily used to treat seizures or fits caused by epilepsy, panic disorder, and involuntary muscular spasms. Disopan 2 can also help with restless leg syndrome.
  • Epilepsy is a common neurological condition characterized by recurring seizures. Seizures are caused by a rapid burst of electrical activity in the brain, which impairs normal brain function.
  • Panic disorder is an anxiety condition characterized by frequent panic or fright attacks. Disopan 2 includes clonazepam, which acts in the brain by raising the level of a relaxing substance called gamma-aminobutyric acid (GABA). This alleviates anxiety and convulsions. (fits). It also aids in the relaxation of stiff muscles.
  • As a result, Disopan 2 can help with the treatment of seizures, panic attacks, and involuntary muscular spasms.

Safety Advices


Alcohol
UNSAFE

You are recommended not to consume alcohol along with Disopan 2  to avoid unpleasant side effects like drowsiness, dizziness, or sleepiness.


Pregnancy
UNSAFE

Disopan 2 Tablet belongs to pregnancy Category D. It is usually not recommended during pregnancy. However, consult your doctor if you are pregnant or planning for pregnancy.


Breastfeeding
CONSULT YOUR DOCTOR

Avoid breastfeeding while on treatment with Disopan 2 Tablet .


Driving
UNSAFE

Disopan 2 Tablet may cause dizziness, drowsiness, and visual disturbances which may affect the ability to drive or operate machinery. So, do not drive or operate heavy machinery if you feel sleepy or dizzy after taking Disopan 2 Tablet 50s.


Kidney
CAUTION

Disopan 2 is to be taken with caution, especially if you have a history of kidney disorders. The dose may have to be adjusted by your doctor.


Liver
CAUTION

Disopan 2 is to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Uses of Disopan 2mg Tablet
  • Seizures
  • Panic Disorder
  • Involuntary muscle spasms
  • Restless leg syndrome
How does Disopan 2mg Tablet work?

Disopan 2mg Tablet belongs to benzodiazepines which work by enhancing the activity of GABA (gamma-aminobutyric acid) an inhibitory neurotransmitter (a chemical in the brain).

Side Effects of Disopan 2mg Tablet
  • Sedation
  • Drowsiness
  • Dizziness
  • Problems with walking and coordination
  • Depression
  • Fatigue, lethargy
  • Problems with memory
Quick Suggestions:
  • This medication has a high potential for addiction or dependence. Take it only as prescribed by your doctor in terms of dosage and duration.
  • Be cautious of dizziness caused by this medication and avoid driving or engaging in activities that require mental focus until you understand its effects on you.
  • It is advised to refrain from consuming alcohol as it can intensify dizziness and drowsiness.
  • Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Notify your doctor if you experience worsening anxiety, depression, anger, violent behavior, or mania while taking this medication. Regular exercise can be beneficial in reducing anxiety by releasing endorphins and improving sleep and self-image.
  • Finding humor in daily life and watching light-hearted shows can help alleviate stress.
  • Incorporating mindfulness practices such as yoga, meditation, mindfulness-based cognitive therapy, and mindfulness-based stress reduction can enhance your mindfulness.
  • Stay hydrated by drinking enough water and limiting or avoiding alcohol and caffeine to relieve anxiety.
  • Include a diet rich in whole grains, vegetables, and fruits. Herbs like turmeric, ginger, and chamomile, known for their anti-inflammatory properties, can be incorporated into meals to reduce inflammation caused by anxiety disorders.
  • Reduce intake of alcohol, caffeine, added sugar, high salt, and high-fat foods. Particularly, avoiding trans fats can help reduce inflammation.
  • Include antioxidants in your daily diet, such as ashwagandha, omega-3 fatty acids, green tea, and lemon.
  • Spending time with friends and family can be beneficial as having a strong social network may lower the risk of anxiety.
  • Do not abruptly discontinue the medication without consulting your doctor, as it may lead to symptoms such as nausea, anxiety, agitation, flu-like symptoms, sweating, tremors, and confusion.
Indication of Disopan 2mg Tablet

Clonazepam is an antiepileptic medication used to prevent and treat seizures. It is classified as a benzodiazepine and also functions as an anti-convulsant. This drug helps control panic attacks by calming the nerves and the brain.

Pharmacology

Clonazepam is a medication that belongs to the benzodiazepine class and exhibits various pharmacological characteristics such as anticonvulsive, sedative, muscle relaxing, and anxiolytic actions. The central effects of benzodiazepines, including clonazepam, are primarily mediated by an increase in GABAergic neurotransmission at inhibitory synapses in the brain.

Benzodiazepines like clonazepam exert their effects by positively modulating the GABA receptor, which is a neurotransmitter receptor involved in inhibitory signaling in the brain. Clonazepam enhances the effect of GABA released in the synaptic cleft, leading to an increased influx of chloride ions through the transmembrane channels of the postsynaptic neuron. This influx of chloride ions hyperpolarizes the neuron, reducing its excitability and resulting in the observed anticonvulsant, sedative, muscle relaxing, and anxiolytic effects.

Additionally, there is evidence suggesting that clonazepam may impact serotonin in animals. It has been observed to suppress various types of paroxysmal activity, including spike and wave discharges seen in absence seizures (petit mal), slow spike wave activity, generalized spike wave patterns, as well as irregular spikes and waves. These effects have been demonstrated in animal studies and electroencephalographic investigations in humans.

Clonazepam has shown efficacy in repressing EEG abnormalities, both in generalized and localized epilepsies, according to the available studies. However, it's important to note that the specific effects and efficacy of clonazepam can vary depending on the individual and the underlying condition being treated. It is always recommended to consult with a healthcare professional for accurate information and guidance regarding the use of clonazepam or any other medication.

Dosage and Administration of Disopan 2mg Tablet

Adults with Seizure Disorders:

  • Initial dose: Should not exceed 1.5 mg/day, divided into three doses.
  • Dosage adjustment: The dose can be increased in increments of 0.5 to 1 mg every 3 days.
  • Purpose of adjustment: Increase the dose until seizures are adequately controlled or until side effects prevent further increases.
  • Maintenance dosage: This must be individualized for each patient based on their response.
  • Maximum daily dose: The recommended maximum daily dose is 20 mg.

Adults with Panic Disorder:

  • Initial dose: 0.25 mg given in two divided doses.
  • Dosage adjustment: After 3 days, the dose can be increased to the target dose for most patients, which is 1 mg/day.

Pediatric Patients (up to 10 years of age or 30 kg of body weight):

  • Initial dose: To minimize drowsiness, the initial dose should be between 0.01 and 0.03 mg/kg/day.
  • Maximum initial dose: The initial dose should not exceed 0.05 mg/kg/day.
  • Dosage frequency: The dose is given in two or three divided doses.

Take Disopan 2mg Tablet as advised by your physician. It can be taken with or without meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Interaction

Disopan 2mg Tablet can potentially interact with several medications:

  • Opioid analgesics (such as alfentanil, buprenorphine, codeine, hydrocodone, and hydromorphone): Concurrent use of  Disopan 2mg Tablet with opioids can result in severe drowsiness, breathing problems, coma, and even death. Caution is advised when combining these medications.
  • Antipsychotic medications (such as droperidol, and olanzapine): Combining  Disopan 2mg Tablet with antipsychotics can increase the risk of excessive sedation and respiratory depression. Close monitoring is recommended.
  • Anesthesia medications (such as ketamine): Concurrent use of  Disopan 2mg Tablet with anesthesia medications may lead to enhanced sedative effects. Proper monitoring is important.
  • Antidepressant medications (such as sodium oxybate): Combining  Disopan 2mg Tablet with certain antidepressants can result in increased sedation and respiratory depression. Careful monitoring is advised.
  • Medications used to lower blood pressure (such as enalapril, amlodipine, felodipine, and indapamide):  Disopan 2mg Tablet may potentiate the blood pressure-lowering effects of these medications. Close monitoring of blood pressure is recommended.
  • Acidity medication (cimetidine): Cimetidine may increase the blood levels of  Disopan 2mg Tablet, leading to an increased risk of side effects. Dose adjustment or monitoring may be necessary.
  • Antibiotic medications (such as rifampicin, and fluconazole): Rifampicin may decrease the blood levels of  Disopan 2mg Tablet, while fluconazole may increase its blood levels. Dose adjustment or monitoring may be required.
  • Anticonvulsants (such as diazepam, lorazepam): Concurrent use of  Disopan 2mg Tabletwith other anticonvulsants can potentiate sedation and respiratory depression. Caution is advised.
Contraindications

Hypersensitivity to benzodiazepines, acute pulmonary insufficiency, acute narrow-angle glaucoma.

Pregnancy & Lactation

There is a lack of sufficient and well-controlled studies on the use of Klonopin (Clonazepam) in pregnant women. The available human data regarding the risk of birth defects caused by this medication are inconclusive. In terms of neurodevelopmental effects, there is insufficient evidence in humans to assess the impact of benzodiazepine exposure during pregnancy.

Administering benzodiazepines, including Klonopin, immediately before or during childbirth can lead to a syndrome characterized by hypothermia, hypotonia, respiratory depression, and difficulties with feeding in the newborn. Furthermore, infants born to mothers who have taken benzodiazepines during the later stages of pregnancy can develop dependence and experience withdrawal symptoms during the postnatal period.

Data from studies involving other benzodiazepines suggest the possibility of adverse developmental effects, such as long-term effects on neurobehavioral and immunological function, in animals exposed to these medications prenatally.

The effects of Klonopin on breastfeeding infants and milk production are unknown. When considering the use of this medication, the potential benefits of breastfeeding in terms of infant development and health should be weighed against the mother's clinical need for therapy and any potential adverse effects on the breastfed infant arising from the medication itself or the underlying maternal condition.

Precautions & Warnings
  • If you are allergic to clonazepam or any benzodiazepine medications (such as diazepam, chlordiazepoxide, bromazepam, or flurazepam), it is important not to take  Disopan 2mg Tablet. You should inform your doctor about any lung disease, glaucoma, muscle weakness (myasthenia gravis), sleep apnea (difficulty sleeping), depression, mood problems, suicidal thoughts or behavior, as well as liver or kidney problems that you may have.
  • Taking  Disopan 2mg Tablet in combination with opioid medicines can lead to severe drowsiness, breathing difficulties, coma, and even death. Therefore, caution should be exercised when using these medications together.
  • If you have a history of alcohol or drug abuse,  Disopan 2mg Tablet should be taken with extreme caution.
  • It is important not to abruptly stop taking Disopan 2mg Tablet, as this can result in withdrawal symptoms. It is advisable to consult your doctor for guidance on gradually reducing the dosage and discontinuing the medication safely.
Storage Conditions

Keep away from light and heat in a dry area. Keep out of children's reach.

Frequently Asked Questions (FAQ)

The effects of Clonazepam lasts for about six to eight hours for adult patients and for twelve hours in children as well as infants.

The effects of clonazepam start to show up in about thirty to forty minutes.

Yes

Avoid foods containing caffeine (tea, coffee, chocolates, etc.) while taking Lonazep 0.25 Tablet, as caffeine stimulates the brain, and Lonazep 0.25 Tablet calms it. Too much caffeine can hinder the calming effects of the medicine and worsen your condition. Additionally, refrain from consuming alcohol during Lonazep 0.25 Tablet treatment, as it may cause excessive sleepiness and increased drowsiness. If you have further questions about your diet while on Lonazep 0.25 Tablet, consult your doctor.

Long-term or high-dose usage of Disopan 2mg Tablet may lead to addiction. Individuals with a history of alcoholism or drug abuse have a higher risk of becoming addicted. Therefore, it's crucial to take Lonazep 0.25 Tablet for the shortest duration and in the lowest effective dose possible.

Avoid abruptly stopping Disopan 2mg Tablet, as it may cause withdrawal effects like depression, nervousness, difficulty sleeping, irritability, sweating, upset stomach, or diarrhea. Sudden cessation could worsen the symptoms and make them harder to treat. Even after taking low doses for a short time, you may experience mood changes, anxiety, restlessness, and disruptions in sleep patterns. Always consult your doctor before discontinuing the medication to ensure a safe and gradual tapering process.
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Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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