Lorfast 10 | Strip

✔️ Dosage & Administration

Adults and children ≥12 years: 1 tablet (10 mg) once daily, preferably in the morning or as needed.

Children 2–12 years:

Body weight >30 kg: 1 tablet (10 mg) once daily.

Body weight ≤30 kg: ½ tablet (5 mg) once daily.

Children <2 years: Not recommended due to lack of established safety and efficacy.

✔️ Overdose Effects

Symptoms of overdose in adults may include somnolence, headache, and tachycardia. In children, palpitations or extrapyramidal symptoms may occur.
Management:

Initiate symptomatic and supportive care immediately.

Administer activated charcoal if the patient presents early.

Induce emesis or perform gastric lavage in conscious patients when appropriate.

✔️ Drug Interactions

No significant or hazardous drug interactions have been reported.
Unlike many antihistamines, Lorfast does not potentiate the effects of alcohol on psychomotor performance.
Coadministration with drugs that inhibit or are metabolized by hepatic cytochrome P450 enzymes (CYP3A4 and CYP2D6)—such as cimetidine, erythromycin, or ketoconazole—may increase plasma concentrations of loratadine, but no clinically significant adverse effects have been reported.

✔️ Side Effects

Clinical trials have shown that the incidence of adverse effects, including sedation or anticholinergic symptoms, is comparable to placebo.
Performance studies demonstrate no impairment in driving ability, cognitive function, or psychomotor performance.

✔️ Contraindications

Lorfast is contraindicated in individuals with hypersensitivity to Loratadine or any of its components.

✔️ Pregnancy & Lactation

Use during pregnancy is not recommended, as adequate human data are unavailable.

Loratadine is excreted in breast milk in small amounts; therefore, nursing mothers should avoid using Lorfast.

✔️ Precautions & Warnings

Use cautiously in patients with hepatic impairment or severe renal insufficiency (eGFR <30 ml/min).

Dose adjustment may be considered based on clinical judgment.

✔️ Storage Conditions

Store in a cool, dry place, away from light and heat.
Keep out of the reach of children.