Intasone 10mg 10pcs

Intasone belongs to a group of medicines called corticosteroids. It is used to treat a variety of diseases and conditions such as severe allergic reactions, allergic conditions, cancer, and skin and eye disorders. Intasone is best taken with food. This will prevent you from getting upset stomach. You need to take it regularly to get the maximum benefit of the medicine. Do not stop taking this medicine without speaking to your doctor as it may worsen your symptoms. This medicine is generally safe with little or no side effects. However, it may cause dizziness, headaches, swollen ankles and, weakness. Taking medicine can also make it harder for your body to fight off infections. Tell your doctor if you have any signs of infection such as a fever or sore throat. Also before taking this medicine, you should let your doctor know all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before taking this medicine.

Uses of Intasone

Severe allergic reactions

Allergic conditions

Cancer

Skin disorders

Eye disorders

Side effects of Intasone

Common

Ankle swelling

How to use Intasone

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Intasone is to be taken with food.

How Intasone works

Intasone is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.

Quick Tips

Intasone helps treat inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems that require either reduction of inflammation or suppression of the immune system.

Do not use it more often or for longer than advised by your doctor.

Take it with food to avoid an upset stomach.

Intasone can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.

Side effects such as mood changes or stomach problems can happen when you start taking Intasone. Inform your doctor if this bothers you.

Do not stop taking Intasone suddenly without talking to your doctor first as it may worsen your symptoms.

Brief Description

Indication

Corticosteroid-responsive dermatoses, hypersensitivity reactions such as, angioedema, status asthmaticus, Soft tissue inflammation, Joint inflammations, Primary or secondary adrenocortical insufficiency, Acute adrenocortical insufficiency, Shock unresponsive to conventional therapy, Congenital adrenal hyperplasia, Hypercalcemia associated with cancer, Nonsuppurative thyroiditis, Rheumatic Disorders, Dermatologic Diseases, (Allergic States, Severe seborrheic dermatitis, Severe psoriasis, Pemphigus, Severe erythema multiforme), Control of severe or incapacitating allergic conditions, (Bronchial asthma, Contact dermatitis, Atopic dermatitis, Serum sickness, Seasonal or perennial allergic rhinitis, Drug hypersensitivity reactions, Urticarial transfusion reactions, Acute noninfectious laryngeal edema), Ophthalmic Diseases, (Herpes zoster ophthalmicus, Iritis, iridocyclitis, Chorioretinitis, Diffuse posterior uveitis and choroiditis, Optic neuritis), Gastrointestinal Diseases, Fulminating or disseminated pulmonary tuberculosis, when used concurrently with appropriate antituberculous chemotherapy, Loeffler's syndrome, Aspiration pneumonitis, Hematologic Disorders, (Acquired, autoimmune hemolytic anemia, Idiopathic thrombocytopenic purpura in adults, Secondary thrombocytopenia, Erythroblastopenia), Neoplastic Diseases, (Leukemias and lymphomas in adults, Acute leukemia of childhood), Edematous States, Acute exacerbations of multiple sclerosis

Administration

Should be taken with food.

Adult Dose

Oral Replacement therapy in adrenocortical insufficiency Adult: 20-30 mg daily in 2 divided doses. Intravenous As supplement in adrenal insufficiency during minor surgery under general anaesthesia Adult: In patients taking >10 mg of prednisolone or its equivalent by mouth daily. 25-50 mg at induction. Resume with usual oral corticosteroid after surgery. As supplement in adrenal insufficiency during moderate or major surgery Adult: In patients taking >10 mg of prednisolone or its equivalent by mouth daily. Usual oral corticosteroid dose on the morning of the surgery followed by 25-50 mg at induction, then similar doses of hydrocortisone tid for 24 hr after moderate surgery or 48-72 hr after major surgery. Resume oral therapy once injections are stopped. Acute adrenocortical insufficiency Adult: 100-500 mg 3-4 times/24 hr according to the severity of the condition and patient response. Fluids and electrolytes should be administered as needed to correct any metabolic disorder. Doses may also be given via IM inj but the response may be slower. Status Asthmaticus 1-2 mg/kg IV q6hr initially for 24 hours; maintenance: 0.5-1 mg/kg q6hr Injection Soft tissue inflammation Adult: As Na phosphate or Na succinate esters: 100-200 mg as local inj. Intra-articular Joint inflammations Adult: As acetate: 5-50 mg depending on size of affected joint.

Child Dose

Oral Replacement therapy in adrenocortical insufficiency Child: 400-800 mcg/kg/day, in 2-3 divided doses. Intravenous Acute adrenocortical insufficiency Child: <1 yr: 25 mg; 1-5 yr: 50 mg; 6-12 yr: 100 mg. Fluids and electrolytes should be administered as needed to correct any metabolic disorder. Doses may also be given via IM inj but the response may be slower. Status Asthmaticus 1-2 mg/kg IV q6hr for 24 hr; not to exceed 250 mg IV Maintenance: 2 mg/kg/day IV divided q6hr

Contraindication

Viral/fungal infections, tubercular or syphilitic lesions, bacterial infections unless used in conjunction with appropriate chemotherapy.

Mode of Action

Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.

Precaution

CHF, hypertension, DM, epilepsy, elderly, patients on prolonged therapy. Gradual withdrawal, pregnancy and lactation. Lactation: Drug enters breast milk; use with caution

Side Effect

Sodium and fluid retention. Potassium and calcium depletion. Muscle wasting, weakness, osteoporosis. GI disturbances and bleeding. Increased appetite and delayed wound healing. Bruising, striae, hirsutism, acne, flushing. Raised intracranial pressure, headache, depression, psychosis, menstrual irregularities. Hyperglycaemia, glycosuria, DM, obesity, moon-face, buffalo hump. Suppression of pituitary-adrenocortical system. Growth retardation in childn (prolonged therapy). Increased susceptibility for infection. Topical use: Dermal atrophy, local irritation, folliculitis, hypertrichosis. Inhaled corticosteroids: May cause hoarseness, candidiasis of mouth and throat. Topical application to the eye: Can produce corneal ulcers, raised IOP and reduced visual function. Intralesional injection: Local hypopigmentation of deeply pigmented skin. Intra-articular injection: Joint damage, fibrosis esp in load bearing joints. Potentially Fatal: Abrupt withdrawal leading to acute adrenal insufficiency. Rapid IV Inj may cause CV collapse.

Interaction

Thiazides may enhance hyperglycaemia and hypokalaemia caused by corticosteroids. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and antihypertensives needs to be increased. Decreases serum conc of salicylates and antimuscarinic agents. Ethanol may enhance gastric mucosal irritation. Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. Mutual inhibition of metabolism between ciclosporin and corticosteroids increase plasma conc of both drugs. Enhanced effect in women taking oestrogens or oral contraceptives.