Dalatic Plus Gel 15gm is a combination medication containing Clindamycin and Tretinoin
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Common side effects include dryness, erythema (skin redness), scaling, burning sensation, skin exfoliation
Clindamycin with Tretinoin gel is indicated for the topical treatment of acne vulgaris.
This is a combination of lincosamide antibiotic Clindamycin phosphate and retinoid Tretinoin. Clindamycin binds with the 50s ribosomal subunit of susceptible bacteria and prevents the elongation of the peptide chain by interfering with the peptidyl transfer, thereby suppressing bacterial protein synthesis. Clindamycin inhibits the activity of Propionibacterium acne and reduces the occurrence of acne. Tretinoin decreases the cohesiveness of follicular epithelial cells and increases the turnover thereby bringing the comedones out.
Adult Dose:
Child Dose:
Safety and effectiveness in children below 12 years of age have not been established.
Concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution. While using concomitantly with Erythromycin, the activity of both Clindamycin and Erythromycin is decreased. So, Clindamycin should not be used with Erythromycin concomitantly. While using concomitantly with neuromuscular medicine, the activity of the neuromuscular medicine is increased. So, care should be taken during these concomitant uses.
Clindamycin and Tretinoin should not be administered to individuals who are hypersensitive to Clindamycin or Tretinoin or any other component of the Gel.
It is not known whether Clindamycin or Tretinoin is excreted in human milk. Exercise special caution while applying Clindamycin or Tretinoin to a nursing mother.
Do not use Clindamycin with Tretinoin to treat infections of the eyes, nose, ear, lips, or on cuts or burns. Avoid direct sunlight on the treated area after application.
Keep away from direct sunlight and moisture, Store below 30°C temperature in a cool and dry place. Keep the medicine out of reach of children.
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