Clinda-A Gel (1.2% + 0.025%)

Composition of Clinda-A Gel

Clindamycin 1.2% + Tretinoin 0.025% 

Uses of Clinda-A Gel

• Manages acne in adults and in adolescents (aged 12 years or older)

Side Effects of Clinda-A Gel

• Increased sebum production
• Skin rash, scaling, sunburn
• Skin discoloration
• Skin redness, irritation, itching, burning, or stinging sensation at the site of application
• Skin dryness, peeling of the skin, sensitivity to sunlight

Quick Suggestions:

• Avoid using products that may cause skin irritation such as harsh soaps, skin cleansers, shampoos, hair removers or waxes, hair coloring or permanent chemicals, detergents, and rough fabrics.
• You are advised to apply any other lotions, creams, or ointments including cosmetics and moisturizers after 30 minutes of applying Clinda-A Gel as using both simultaneously may reduce the effectiveness of Clinda-A Gel.
• Avoid contact with Clinda-A Gel with the nose, mouth, eyes, or ears. In case Clinda-A Gel comes in contact with these areas accidentally, rinse with water.
• Do not squeeze, pop, or pick spots as it may worsen them and cause permanent scarring.

Indication of Clinda-A Gel

Clindamycin with Tretinoin gel is indicated for the topical treatment of acne vulgaris.

Pharmacology

Clinda-A Gel combines Clindamycin phosphate, a lincosamide antibiotic, with Tretinoin, a retinoid. Clindamycin binds to the 50s ribosomal subunit of susceptible bacteria, preventing peptide chain elongation and inhibiting bacterial protein synthesis by interfering with peptidyl transfer. This action reduces the occurrence of acne by inhibiting the activity of Propionibacterium acne. Tretinoin promotes cell turnover and reduces the cohesion of follicular epithelial cells, helping to clear comedones.

Dosage & Administration of Clinda-A Gel

Adult Dose:

• Condition: Acne Vulgaris
• Administration: Apply a pea-sized amount of gel once daily, preferably at bedtime.
• Duration: Continue treatment for 12 weeks.

Child Dose:

• Age <12 years: Safety and efficacy not established.
• Age >12 years: Apply a pea-sized amount of gel once daily, preferably at bedtime.

1. Gently wash the face or affected area with warm water or mild soap.
2. Allow the skin to dry completely (approximately 30 minutes).
3. Apply a pea-sized amount of gel to your fingertip and spread it evenly over the face.

Interaction

Use caution when combining with other potentially irritating topical treatments, such as medicated or abrasive soaps and cleansers, products with high alcohol content, astringents, spices, or lime. Clindamycin should not be used simultaneously with Erythromycin as their actions can be reduced when used together. When used with neuromuscular medications, the activity of these medications can be enhanced. Exercise caution when using these products together.

Contraindications

Do not use Clindamycin or Tretinoin in individuals who are hypersensitive to any component of the gel.

Pregnancy & Lactation

It is not known whether Clindamycin or Tretinoin is excreted in human milk. Use extreme caution when applying these medications to a breastfeeding mother.

Precautions & Warnings

• Do not apply Clinda-A Gel to cuts, open wounds, broken, sunburnt, or sensitive skin areas.
• Avoid sun exposure while using Clinda-A Gel as it may make the skin more sensitive to sunlight and cause sunburn.
• Wear protective clothing and use sunscreen while going out to protect your skin from sunburn.
• If you have intestine problems or eczema, please inform your doctor before taking Clinda-A Gel.
• If you are pregnant or breastfeeding, please inform your doctor before taking Clinda-A Gel.

Storage Conditions:

Store below 25°C, away from light and moisture. Keep out of the reach of children.