Nobesit 500mg (60pcs Box) - ePharma
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Nobesit 500mg (60pcs Box)

Generic: Metformin Hydrochloride

Type: Tablet

Pack Size: 60 Pcs

Generic Name: Metformin Hydrochloride, 

Manufacturer: Incepta Pharmaceuticals Ltd.


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Discount Price: ৳ 223.2
MRP: ৳ 240 7% Off

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Description:

Indications

In order to improve glycemic control, patients with type 2 diabetes mellitus who are not adequately controlled on Vildagliptin or Metformin Hydrochloride alone, or who are already receiving treatment with the combination of Vildagliptin and Metformin Hydrochloride as separate tablets, should take this tablet in addition to a healthy diet and regular exercise.

Pharmacology

Vildagliptin acts fundamentally by hindering DPP-4 (Dipeptidyl peptidase-4), the chemical mindful for the debasement of the incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). The organization of Vildagliptin comes about in a quick and total hindrance of DPP-4 action coming about in expanded fasting and postprandial endogenous levels of the incretin hormones GLP-1 and GIP. By expanding the endogenous levels of these incretin hormones, Vildagliptin increments affront emission from the pancreatic beta-cell and diminishes glucagon discharge from the alpha cell. The improved increment within the insulin/glucagon proportion amid hyperglycemia due to expanded incretin hormone levels comes about in a diminish in fasting and postprandial hepatic glucose generation, driving to reduced glycemia. Metformin Hydrochloride could be a biguanide sort of verbal antihyperglycemic medication utilized within the administration of sort 2 diabetes. It brings down both basal and postprandial plasma.

Dosage & Administration

Metformin immediate-release tablet: 

The dosage of Metformin Hydrochloride must be individualized on the basis of both effectiveness and tolerance, while not exceeding the maximum recommended daily doses.

Adult:

  • Metformin's standard starting dose is 500 mg twice daily or 850 mg once daily, taken with meals. Increases in dosage should be made in divided doses of 500 mg every week or 850 mg every two weeks, up to a maximum of 2000 mg per day. A maximum daily dose of 2550 mg of glucosamine may be given to patients who need additional glycemic control. Taking doses over 2000 mg three times daily with meals may improve tolerance.

Children: 

  • Metformin is typically started with a dose of 500 mg twice daily, taken with meals. Increases in dosage should be made in weekly increments of 500 mg, up to a daily cap of 2000 mg, administered in divided doses.

Metformin extended-release tablet: 

  • Swallow the Metformin XR tablet whole and never crush, cut, or chew.

Adult: 

  • 500 mg once daily with dinner is the typical Metformin XR starting dose. The dose should be raised in 500 mg weekly increments, up to a maximum of 2000 mg taken with a meal once per day in the evening, or 1000 mg twice daily. Up to the maximum recommended daily dose, patients taking metformin immediate-release tablets may switch to metformin extended-release tablets.

Children:

  • Metformin extended-release tablet has not been studied in children.

Renal impaired patient: 

  • Do not use Metformin in patients with eGFR below 30 mL/min/1.73 m2. Assess the risk/benefit of counting if eGFR falls below 45 mL/min/1.73 m2.

Interaction

No clinically pertinent pharmacokinetic interaction was watched when Vildagliptin (100 mg once day by day) was co-administered with Metformin Hydrochloride (1,000 mg once day by day). Vildagliptin incorporates a low potential for sedate intuition. Since Vildagliptin isn't a cytochrome P (CYP) 450 chemical substrate nor does it restrain nor actuate CYP 450 chemicals, it isn't likely to connect with co-medications that are substrates, inhibitors, or inducers of these proteins. As a result of these considers no clinically significant intelligence with other verbal antidiabetics (glibenclamide, pioglitazone, metformin hydrochloride), amlodipine, digoxin, ramipril, simvastatin, valsartan or warfarin were watched after co-administration with vildagliptin. On the other hand, furosemide, nifedipine, and glyburide increment Cmax and blood AUC of Metformin with no alteration in renal clearance of Metformin.

Contraindications

This combination is contraindicated in patients with known touchiness to Vildagliptin or Metformin Hydrochloride or to any of the excipients. It is contraindicated in patients with renal illness or renal brokenness, intense myocardial localized necrosis, and septicemia. It is additionally contraindicated in patients with congestive heart disappointment patients and in patients with intense or inveterate metabolic acidosis, counting diabetic ketoacidosis, with or without coma. It ought to be incidentally suspended in patients experiencing radiologic thinks about including intravascular organization of iodinated differentiate materials, since the utilization of such items may result in an intense change of renal work.

Side Effects

  • Nausea
  • Headache
  • Vomiting
  • Taste change
  • Hypoglycemia
  • dizziness
  • Diarrhea
  • Tremors
  • Abdominal pain
  • Loss of appetite

Pregnancy & Lactation

There are no satisfactory and well-controlled ponders in pregnant ladies and so, this combination ought to not be utilized amid pregnancy unless the potential advantage legitimizes the potential chance for the embryo. No ponders have been conducted with the components of this combination. Because it isn't known whether Vildagliptin and/or Metformin Hydrochloride is excreted in the human drain this combination ought to not be managed for breastfeeding ladies.

Precautions & Warnings

There are no satisfactory and well-controlled ponders in pregnant ladies and so, this combination ought to not be utilized amid pregnancy unless the potential advantage legitimizes the potential chance for the embryo. No ponders have been conducted with the components of this combination. Because it isn't known whether Vildagliptin and/or Metformin Hydrochloride is excreted in the human drain this combination ought to not be managed for breastfeeding ladies.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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