Flamyd 250mg 10pcs

Indications

An antibiotic drug called Flamyd 250 aids your body in battling parasitic and bacterial illnesses. It is used to treat infections of the skin, bones, brain, heart, lungs, stomach, intestines, and vagina. After surgery, Flamyd 250 helps prevent infection. Additionally, it is used to treat leg ulcers, pressure sores, and tooth infections. It is preferable to take this medication after a meal. To reap the greatest benefits, it should be taken at the same time every day. Depending on what you are being treated for and how severe it is, your doctor will advise you on how much to take, but you must take this antibiotic exactly as directed.

Pharmacology

Metronidazole is an antibacterial medication that belongs to the imidazole family and is used as an antiprotozoal agent. Anaerobes decrease the 5-nitro group of Metronidazole metabolically. Metronidazole's bactericidal effect is due to the reduced form of the antibiotic interacting with DNA, according to studies.

These conditions are all treated with metronidazole:

• Prevent anaerobic bacteria-related postoperative infections (especially anaerobic Bacteroides and streptococci).
• treatment of anaerobic bacteria-induced sepsis, bacteremia, peritonitis, brain, pelvic, and pelvic cellulitis, as well as postoperative wound infections.
• genitourinary trichomoniasis treatment
• bacteria-caused vaginitis (also called nonspecific vaginitis).
• Amebiasis in all its forms (transmitted by intestinal and extraintestinal diseases and asymptomatic cysts).
• Giardiasis.
• acute gingivitis with ulcers.
• Leg ulcers and anaerobic infection-related pressure sores.
• Anaerobic organisms induce an acute tooth infection.
• pseudomembranous colitis brought on by antibiotics.

Dosage & Administration

Tablet and Suspension:

Trichomoniasis (Adults & Children over 10 yrs)-

• 200 mg tid or 400 mg bid for 7 days
• 800 mg in the morning and 1-2 gm at night for 2 days
• 2 gm as a single dose for 1 days

Trichomoniasis (Children)-

• Children 7-10 yrs: 100 mg tid
• Children 3-7 yrs: 100 mg bid
• Children 1-3 yrs: 50 mg tid

Intestinal amoebiasis (Adults & Children over 10 yrs)- 

• 800 mg tid for 5 days

Intestinal amoebiasis (Children)-

• Children 7-10 yrs: 400 mg tid
• Children 3-7 yrs: 200 mg qid
• Children 1-3 yrs: 200 mg tid

Extra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs)-

• 400-800 mg tid for 5-10 days

Extra-intestinal & Asymptomatic amoebiasis (Children)-

• Children 7-10 yrs: 200-400 mg tid
• Children 3-7 yrs: 100-200 mg qid
• Children 1-3 yrs: 100-200 mg tid

Giardiasis (Adults & Children over 10 yrs)-

2 gm once daily for 3 days

Giardiasis (Children)-

• Children 7-10 yrs: 1 gm once daily
• Children 3-7 yrs: 600-800 mg once daily
• Children 1-3 yrs: 500 mg once daily

Acute ulcerative  gingivitis (Adults & Children over 10 yrs)-

200 mg tid for 3 days

Acute ulcerative  gingivitis (Children)-

• Children 7-10 yrs: 100 mg tid
• Children 3-7 yrs: 100 mg bid
• Children 1-3 yrs: 50 mg tid

Acute dental infections (Adults & Children over 10 yrs)-

• 200 mg tid for 3-7 days

Bacterial Vaginosis (Adults & Children over 10 yrs)-

• 400 mg bid for 7 days
• 2 gm as a single dose for 1 days

Leg ulcers and pressure sores (Adults & Children over 10 yrs)-

• 400 mg tid for 7 days

Anaerobic infections (Adults & Children over 10 yrs)-

• 800 mg initially and then 400 mg tid for 7 days

Anaerobic infections (Children)-

• Children 1-10 yrs: 7.5 mg/kg tid

Surgical prophylaxis (Adults & Children over 10 yrs)-

• 400 mg tid started 24  hours before  surgery for 1 days

Surgical prophylaxis (Children)-

• Children 1-10 yrs: 7.5 mg/kg tid

Vaginal Gel:

One applicator full of metronidazole gel, or around 5 grams and 37.5 milligrams of metronidazole, should be injected intravaginally once or twice a day for five days. Metronidazole gel should be taken at bedtime for a single daily dose.

Suppository:

Anaerobic Infections-

• Adults: 1 g every eight hours for the first three days, then 1 g every twelve.
• Children aged 5 to 10: 500 mg every eight hours for three days, then every twelve hours; above 10 years: adult dosage.

Surgical Precautions

• Adults: 1 g two hours prior to surgery; high-risks procedures, up to three more doses of 1 g may be administered every eight hours.
• Children aged 5 to 10 years: 500 mg two hours prior to surgery; for high-risk procedures, up to three additional 500 mg doses may be given every eight hours.

IV Infusion:

• Metronidazole intravenous infusion requires no dilution and should not be mixed with any other drugs prior to administration.

Adults and children over 12 years: 

• A maximum of 4 g should not be consumed in a 24-hour period, and 500 mg 8 should be infused at a rate of 5 ml/minute every hour. Most patients only need a 7-day course of treatment, however, this might be extended in circumstances where reinfection is anticipated. For surgical prophylaxis, treatment should begin just before surgery and continue for the next 24 hours in 8-hourly dosages.

Children younger than 12 years old: 

• 5 ml/minute, or 7.5 mg/kg body weight, every eight hours.

Interaction

Use in conjunction with disulfiram may result in psychotic responses. The impact of oral anticoagulants may be enhanced. may make lithium poisoning more likely. Can increase the 5-fluorouracil's toxicity by decreasing renal clearance. may raise ciclosporin levels in the blood. may lead to a significant increase in busulfan plasma levels and severe busulfan toxicity. reduced serum concentrations as a result of phenobarbital and phenytoin's enhanced metabolism.

Contraindications

Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.

Side Effects

Metallic taste

Nausea

Vomiting

Diarrhea

Drowsiness

Rashes may be observed during treatment.

Pregnancy & Lactation

Metronidazole is classified as a pregnancy category B by the US Food and Drug Administration. However, no appropriate and well-controlled trials in pregnant women have been conducted. Because animal reproduction studies do not always anticipate a human response, this medication should only be taken during pregnancy if absolutely necessary. Human milk has been found to contain metronidazole. When Metronidazole is given to a breastfeeding mother, care should be used.

Precautions & Warnings

If metronidazole must be given for a longer period of time than is typically suggested, it is recommended that hematological tests, particularly leucocyte counts, be performed on a regular basis and that patients be watched for adverse responses such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, convulsive seizures). Inform your doctor if you have liver disease. Your dose may need to be adjusted in severe liver disease.

Patients with hepatic encephalopathy should be given metronidazole with care.

Metronidazole might cause urine to discolor, therefore patients should be informed.

Storage Conditions

Keep it below 30°C. Protect yourself from the sun. Medicines should be kept out of the reach of youngsters. Do not use it beyond the expiration date.