Azyth 500mg Tablet

Uses of Azyth 500mg Tablet

• Bronchitis
• Sinusitis
• Pharyngitis/Tonsillitis
• Upper Respiratory Tract Infection
• Lower Respiratory Tract Infection
• Skin And Structure Infection
• Bacterial Infections

How does Azyth 500mg Tablet work?

Azyth 500mg Tablet works by inhibiting protein synthesis by binding itself to 50S ribosomal subunits of the sensitive micro-organism. This infringes on transpeptidation and translocation and thus inhibits protein synthesis and cell growth.

Side Effects of Azyth 500mg Tablet

The more common side effects of azithromycin oral tablet can include:

• diarrhea
• nausea
• abdominal (belly) pain
• vomiting
• headache

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Quick Suggestions:

• Complete the full course of treatment: It is important not to skip any doses and finish the full course of treatment, even if you start feeling better. Stopping the medication early may allow the infection to come back and make it harder to treat.
• Timing of administration: Take Azyth 500mg Tablet 1 hour before or 2 hours after a meal. This helps optimize the absorption and effectiveness of the medication.
• Antacids: Avoid taking antacids 2 hours before or after taking Azyth 500mg Tablet. Antacids can interfere with the absorption of the medication.
• Diarrhea: Diarrhea may occur as a side effect of Azyth 500mg Tablet. It should generally stop once the course of treatment is complete. However, if diarrhea persists or if you notice blood in your stools, inform your doctor immediately.
• Allergic reactions: Stop taking Azyth 500mg Tablet and seek medical attention immediately if you develop an itchy rash, swelling of the face, throat, or tongue, or experience breathing difficulties. These may be signs of an allergic reaction.
• Probiotics: After completing the full course of Azyth 500mg Tablet, taking probiotics can help restore healthy bacteria in the intestine. Probiotics can be found in certain fermented foods like yogurt, cheese, sauerkraut, and kimchi.
• High-fiber foods: Including more fiber-enriched foods in your diet can stimulate the growth of healthy gut bacteria. Whole grains like whole-grain bread and brown rice are examples of fiber-rich foods that can be beneficial.
• Calcium-enriched foods: Avoid excessive intake of calcium-enriched foods and drinks while taking Azyth 500mg Tablet, as they might interfere with its effectiveness.

Indication of Azyth 500mg Tablet

Azyth is an antibiotic that is used in adults and children to treat bacterial infections of the respiratory tract, ear, nose, throat, lungs, skin, and eyes. It is also useful in the treatment of typhoid fever and some sexually transmitted diseases such as gonorrhea. Azyth is a broad-spectrum antibiotic that is effective against many gram-positive bacteria, some gram-negative bacteria, and other microorganisms. This medication is taken orally, preferably one hour before or two hours after eating. It should be taken on a regular basis at evenly spaced time intervals, as directed by your doctor.

Pharmacology

Azithromycin is acid-stable, so it can be taken orally without fear of being destroyed by stomach acids. It is quickly absorbed; its retention is more noticeable on a purge stomach. For verbal measurement shapes, the time to peak concentration in adults ranges from 2.1 to 3.2 hours. Because of its high concentration in phagocytes, azithromycin is efficiently transported to the site of the disease. Massive amounts of azithromycin are released during dynamic phagocytosis. Azithromycin concentrations in tissues can be more than 50 times higher than in plasma. This is frequently caused by particle catching and high lipid solubility. Because azithromycin is acid-stable, it can be taken orally without fear of being destroyed by gastric acids. It is quickly retained, and its retention is more noticeable on a purge stomach. For verbal measurement shapes, the time to crest concentration in adults ranges from 2.1 to 3.2 hours. Because of its high concentration in phagocytes, azithromycin is efficiently transported to the site of contamination. Azithromycin in high concentrations is released during dynamic phagocytosis. Azithromycin concentrations in tissues can be more than 50 times higher than in plasma. Usually because of particle catching and high lipid solubility.

• Microbiology: Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. Nucleic acid synthesis is not affected. Azithromycin has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections:
• Aerobic and facultative gram-positive microorganisms: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumonia, Streptococcus pyogenes
• Aerobic and facultative gram-negative microorganisms: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae
• Other microorganisms: Chlamydia pneumoniae, Chlamydia trachomatis, Mycoplasma pneumonia, and Beta-lactamase production should have no effect on azithromycin activity.
• Aerobic and facultative gram-positive microorganisms: Streptococci (Groups C, F, G), Viridans group streptococci
• Aerobic and facultative gram-negative microorganisms: Bordetella pertussis, Legionella pneumophila
• Anaerobic microorganisms: Peptostreptococcus species, Prevotella Livia.

Dosage & Administration of Azyth 500mg Tablet

Adults:

• For respiratory system infections: Take 500 mg once daily orally for 3 days, or take 500 mg on day 1 and then 250 mg once daily for days 2-5 (4-day regimen).
• For sexually transmitted diseases caused by Chlamydia trachomatis: Take 1 gram as a single dose, or take 500 mg on day 1 followed by 250 mg once daily for the next 2 days.

Children:

• For children over 6 months: Take 10 mg/kg body weight once daily for 3 days.
• If bodyweight is 15-25 kg: Take 200 mg (1 teaspoonful) for 3 days.
• If bodyweight is 26-35 kg: Take 300 mg (1½ teaspoonfuls) for 3 days.
• If bodyweight is 36-45 kg: Take 400 mg (2 teaspoonfuls) for 3 days.

For typhoid fever, the recommended dosage is 500 mg (2½ teaspoonfuls) once daily for 7-10 days.

Please note that these dosages are general guidelines and may vary depending on the specific condition and individual patient factors. It is essential to follow the prescribed dosage and duration of treatment as instructed by your doctor.

Interaction

Interaction with Alcohol: The interaction of Azyth 500mg Tablet with alcohol is unknown. It is advisable to consult your doctor before consuming alcohol while taking this medication.

Interaction with Lab Tests: Monitoring of liver function tests and complete blood count (CBC) differential should be done while the patient is on this medicine.

Interaction with Other Medicines:

• Increased effect/toxicity: Azyth 500mg Tablet may increase levels of drugs such as tacrolimus, phenytoin, ergot alkaloids, alfentanil, astemizole, terfenadine, bromocriptine, carbamazepine, cyclosporine, digoxin, disopyramide, and triazolam. Caution is advised when administering these drugs together.
• Avoid use with pimozide: Significant risk of cardiotoxicity exists when Azyth 500mg Tablet is used with pimozide.
• No effect on warfarin or theophylline response: Azyth 500mg Tablet does not affect the response to warfarin or theophylline. However, caution is still advised when these drugs are used together. Azyth 500mg Tablet has interactions with various medications, including anti-nausea pills (domperidone), mental health pills (pimozide, amisulpride), anti-migraine medicines (ergotamine, dihydroergotamine), anti-cholesterol pills (simvastatin), bladder weakness medicine (tolterodine), and anti-gout/arthritis medicine (colchicine). Taking these drugs with Azyth 500mg Tablet may cause serious side effects.

Interaction with Food: The rate and extent of gastrointestinal absorption of Azyth 500mg Tablet may decrease when taken with food. It is recommended to take this medicine on an empty stomach.

Interaction with Diseases:

• QT Prolongation: Inform your doctor if you have an arrhythmia, any heart disease, or take drugs that prolong QT intervals, such as psychiatric drugs or anti-arrhythmic drugs.
• Liver Disease: Inform your doctor if you have any liver disease or take drugs that cause liver damage (e.g., TB drugs, HIV drugs).
• Myasthenia Gravis: Azyth 500mg Tablet may interact with myasthenia gravis. Caution is advised in such cases.

Other Considerations:

• Use with caution in patients with hepatic dysfunction, as hepatic impairment with or without jaundice has occurred primarily in older children and adults. Discontinue use if symptoms such as malaise, nausea, vomiting, abdominal colic, and fever occur.
• Azyth 500mg Tablet may mask or delay symptoms of incubating gonorrhea or syphilis, so appropriate culture and susceptibility tests should be performed before initiating treatment.
• Pseudomembranous colitis, a severe intestinal condition, has been reported with the use of macrolide antibiotics.

Contraindications

Patients who are hypersensitive to Azyth 500 or any other macrolide antibiotic should avoid taking it. Ergot derivatives and azithromycin should not be taken together. Patients with hepatic disorders should avoid Azyth 500.

Pregnancy & Lactation

The pregnancy Category of Azithromycin is B. Creature generation ponders have illustrated that Azithromycin has no proof of hurt to the baby. There are no satisfactory and well-controlled things about pregnant ladies. Since creature generation considers is not continuously prescient of human reaction, Azithromycin ought to be utilized amid pregnancy as it were in the event that satisfactory choices are not accessible. It isn't known whether Azithromycin is discharged in the breast drain. So, caution ought to be worked out when Azithromycin is managed by nursing ladies.

Precautions & Warnings

• Antacids should not be taken two hours before or after taking Azyth.
• Diarrhea may occur as a side effect, but it should subside once your course is finished. If it does not stop or if you find blood in your stools, contact your doctor.
• If you develop an itchy rash, swelling of the face, throat, or tongue, or breathing difficulties while taking Azyth, stop taking it immediately and notify your doctor.
• Observation for signs of superinfection with non-susceptible organisms, especially fungus, is suggested with any antibiotic. In patients with renal impairment, there is no need to alter the dose.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach