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5HTP Capsule 6pcs
- Promotes relaxation and reduces anxiety
- Enhances mood and sleep quality
- Improves sleep patterns and regulates the cycle
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✅ Description:
- Medicinal Part: Brown-grey powdered seed with a peppery odor.
- Botanical Description: A stout, woody, climbing shrub growing to about 3m with greenish flowers and inflated black pods.
- Habitat: Mainly found in West-Central Africa, in thickets, often associated with termite mounds on plains, in forests, secondary vegetation, and old farms. It is an evergreen, vigorous plant with wide adaptability. Commercial production of 5-HTP involves extraction from the seeds.
Valerian: Valerian is an herb commonly used as a sleep aid, available in various commercial forms. The extract from Valeriana officinalis, a flowering plant native to Europe and Asia and also found in North America, contains over 150 active constituents. Valerian root extract includes the fresh or carefully dried subterranean parts of the plant, such as rhizomes, roots, and stolons.
✔️ Composition of 5HTP Capsule
Each vegetable capsule contains:
- 5-Hydroxytryptophan (from Griffonia simplicifolia): 100 mg
- Powdered valerian extract (from Valeriana officinalis): 100 mg
✔️ 5-HTP is indicated for:
- Anxiety
- Insomnia
- Depression
- Chronic headache
- Fibromyalgia
✔️ Side Effects of 5HTP Capsule
- Drowsiness
- Nausea
- Vomiting
- Stomach pain
- Heartburn
- Diarrhea
- Loss of interest in sex
✔️ Pharmacology
5-Hydroxytryptophan (5-HTP): Converted "in vivo" to serotonin, a neuro-hormonal transmitter released by neurons in the brain, spinal cord, and sympathetic ganglia. It is derived from the seeds of the African plant Griffonia simplicifolia. 5-HTP, an aromatic amino acid naturally produced from L-tryptophan, is extracted commercially from these seeds.
Valerian Extract: Effective in treating mild-to-moderate sleeping disorders without adverse effects on REM sleep or significant hangover effects. Valerian has sedative-hypnotic, anxiolytic, antidepressant, anticonvulsant, and antispasmodic properties.
5-HTP primarily increases serotonin levels within the central nervous system. It has also been shown to raise levels of other neurotransmitters and CNS chemicals, such as melatonin, dopamine, norepinephrine, and beta-endorphin, following oral administration.
Valepotriate in valerian binds to dopamine receptors. Valerenic acid appears to inhibit the enzyme system responsible for GABA catabolism in the central nervous system, thereby increasing GABA concentration and decreasing CNS activity.
Valerian extracts, containing amino acids and valeric acid, bind with the GABA-A receptor in the brain cortex. Valerian extract inhibits GABA uptake and stimulates its release, leading to increased GABA concentration in synaptic clefts. Valerenic acid may inhibit enzymes that break down GABA, thus elevating GABA levels and producing a CNS-depressing effect.
✔️ Dosage & Administration of 5HTP Capsule
Take 1 or 2 vegetable capsules daily, or as directed by a registered physician.
- চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
✔️ Interaction
- Carbidopa: Concurrent use may increase the risk of developing scleroderma-like illness in susceptible individuals.
- Monoamine Oxidase Inhibitors (MAOIs) & Selective Serotonin Reuptake Inhibitors (SSRIs): Concurrent use may increase the risk of serotonin syndrome (symptoms include hypertension, hyperthermia, myoclonus, and mental status changes). Combining 5-HTP with SSRIs may enhance the risk of serotonergic side effects. Valerian may potentiate the sedative effects of barbiturates, alcohol, and benzodiazepines.
✔️ Contraindications
The World Health Organization (WHO) advises against using valerian for children under 18 year without medical supervision.
✔️ Pregnancy & Lactation
The safety of 5-HTP during pregnancy or lactation has not been established in controlled trials; therefore, it should not be used during pregnancy.
✔️ Storage Conditions
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
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