Methasol-N 5 ml

Indications of Methasol-N 5 ml Ophthalmic Solution

Eyes: Inflammatory conditions (eg, uveitis, marginal keratitis, allergic conjunctivitis, blepharitis, and perineitis) predispose to the development of bacterial infection.

Ear: Otitis externa and other inflammatory conditions when bacterial infection is present or suspected.

Nose: Inflammation, where infection is present or suspected.

Pharmacology of Methasol-N 5 ml Ophthalmic Solution

Betamethasone is an effective corticosteroid in inflammatory dermatoses. It is also effective in less sensitive conditions such as psoriasis.

Betamethasone has a 16βmethyl group which enhances the molecule's anti-inflammatory activity and reduces the water and sodium retention properties of the 9 carbon-bound fluorine atom.

Neomycin sulfate is bactericidal against many commonly associated bacteria. related to skin infections. Neomycin is a broad-spectrum antibiotic that is actively transported across bacterial cell membranes, binds to specific receptor proteins on the 30s subunit of the bacterial ribosome, and interferes with the promoter complex between mRNAs. tin) and the 30s subunit, which inhibits the protein. synthesis. DNA can be misread, thus producing non-functional proteins; polyribosomes are cleaved and are unable to synthesize proteins.

Dosage & Administration of Methasol-N 5 ml Ophthalmic Solution

Drops:

• Eye: 1 drop instilled into the eye every one or two hours until control is achieved, when the frequency may be reduced.
• Ear: 2 or 3 drops instilled into the ear, every two or three hours until control is achieved, when the frequency can be reduced.
• Nose: 2 or 3 drops instilled into each nostril two or three times daily.

Eye Ointment: It should be applied thinly and evenly to the conjunctival sac at night (If eye drops used during day) or 3-4 times daily (if ointment used alone).

Contraindications

Viral, fungal, tuberculous or purulent conditions. Use in the eye is contraindicated if glaucoma is present or wherein herpetic keratitis (for example, dendritic ulcer) is considered a possibility. Inadvertent use of topical steroids in the last condition may result in expanding ulcer and marked visual deterioration. Preparations containing neomycin should not be used for the treatment of otitis external when the drum of the head is pierced due to the risk of otoxicity.

Side Effects of Methasol-N 5 ml Ophthalmic Solution

Acute sensitization to neomycin is a rare but possible occurrence following topical application to the eye. Corticosteroid eye drops cause a large increase in intraocular pressure in a small percentage of the population, including most people with a family history of glaucoma. A larger proportion of adults may perceive a more moderate increase if treatment is continued for more than a few weeks. Corneal thinning leading to perforation has occurred with the use of topical corticosteroids. Cataracts are thought to have occurred after excessive prolonged treatment of eye diseases with topical corticosteroids.

Pregnancy & Lactation

Classified category of pregnancy. The FDA has not yet classified the drug in a specific pregnancy category. Topical administration of corticosteroids to pregnant animals can cause fetal development anomalies. The relevance of this discovery to human beings has not been established; However, topical steroids should not be widely used during pregnancy, that is, in large quantities or for prolonged periods.

Precautions & Warnings

Steroids should not be administered to "red eyes" until a definitive diagnosis has been made. Ophthalmic treatment with steroid preparations should not be repeated or prolonged without regular review to exclude erected intraocular pressure or unsuspected infections. The topical useless use of neomycin-containing products should be avoided to minimize the occurrence of neomomomomylyted organisms (and cross-body for other aminoglycosides).

Therapeutic Class

Ophthalmic steroid - antibiotic combined preparations

Storage Conditions

Store below 25° C