Naproxen Plus Tablet | 20mg+500mg |
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Naproxen Plus Tablet

Generic: Naproxen + Esomeprazole

Type: Tablet

Pack Size: 10 Pcs

Naproxen+Esomeprazole is used for pain relief.

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✅ Description:

Naproxen Plus Tablet is a combination of Naproxen and esomeprazole, belonging to the group of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or painkillers used to reduce pain and inflammation. Naproxen works by blocking certain chemicals that cause pain and swelling, while esomeprazole helps prevent stomach irritation caused by Naproxen.

Take Naproxen Plus Tablet as prescribed by your doctor for the duration recommended based on your medical condition. Common side effects may include indigestion, stomach pain, constipation, dizziness, nausea, and diarrhea, which usually resolve over time.

Before taking this medicine, inform your doctor about any allergies to Naproxen, esomeprazole, NSAIDs, or other medications. If you are pregnant, breastfeeding, or have a history of heart rhythm problems or ulcers caused by painkillers, consult your doctor before using Naproxen Plus Tablet. Patients above 65 years of age or with pre-existing cardiac, gastrointestinal, respiratory, liver, kidney diseases, or bleeding disorders should use the medicine under the doctor's guidance. Keep your doctor informed about your health condition and medications to avoid any potential side effects.

Safety Advices


Alcohol
UNSAFE

It is unsafe to consume alcohol with Naproxen Plus Tablet.


Pregnancy
UNSAFE

Naproxen Plus Tablet may be unsafe to use during pregnancy. Consult your doctor before using it, as limited human studies and animal studies have shown harmful effects on the developing baby.


Breastfeeding
CONSULT YOUR DOCTOR

Naproxen Plus Tablet is safe to use during breastfeeding. It is not harmful to the baby as studies suggest the drug does not pass into breast milk significantly.


Driving
CAUTION

Naproxen Plus Tablet may cause side effects that can affect your ability to drive. It may make you feel dizzy, depressed, sleepy, and tired, or affect your vision, which can impact your driving ability.


Kidney
CONSULT YOUR DOCTOR

Use Naproxen Plus Tablet with caution in patients with kidney disease. Dose adjustment may be needed. Consult your doctor for proper guidance.


Liver
CAUTION

Use Naproxen Plus Tablet with caution in patients with Liver disease. Dose adjustment may be needed. Consult your doctor for proper guidance.

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✔️ Uses of Naproxen Plus Tablet
  • Pain Relief
✔️ How does Naproxen Plus Tablet work?

Naproxen Plus Tablet is a pain-relieving medication that contains a combination of two medicines: Naproxen and Esomeprazole. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers responsible for causing pain, fever, and inflammation (redness and swelling). Esomeprazole is a proton-pump inhibitor that reduces stomach acid levels, protecting the stomach lining from damage caused by Naproxen.

✔️ Side Effects of Naproxen Plus Tablet
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Indigestion
  • Flatulence
  • Stomach pain
  • Flu-like symptoms
✔️ Quick Suggestions:
  • Naproxen Plus Tablet is used to treat various painful conditions.
  • Take it with a glass of milk in order to prevent side effects such as indigestion.
  • If you have asthma, symptoms such as wheezing or breathlessness might get worse with Naproxen Plus Tablet. In such a case see your doctor right away.
  • Inform your doctor if you have or ever had ulcers in your stomach or intestines.
  • Inform your doctor if you are planning to have an operation (even a minor one, such as tooth extraction) since Naproxen Plus Tablet increases the risk of bleeding.
✔️ Indication of Naproxen Plus Tablet

Naproxen Plus Tablet contains Naproxen and esomeprazole (antacid). Naproxen is an anti-inflammatory and analgesic agent that reduces inflammation and relieves pain by blocking the COX enzyme responsible for producing pain-causing substances called prostaglandins. This reduces pain, swelling, and joint stiffness in various conditions, including fibrositis, tenosynovitis, low back pain, strains, and sprains.

Naproxen, like other NSAIDs, may cause gastric discomfort and increase the risk of stomach ulcers. To address this, it is combined with esomeprazole, a proton pump inhibitor that reduces stomach acid secretion. This combination helps minimize gastric irritation and ulceration risk, making it suitable for long-term treatment in individuals with pre-existing stomach ulcers or a history of developing stomach ulcers while using NSAIDs.

✔️ Pharmacology

Naproxen Plus Tablet consists of a fast-releasing Esomeprazole Magnesium coating and an enteric-coated Naproxen core. Esomeprazole is released in the stomach first, while Naproxen dissolves in the small intestine.

Naproxen is an NSAID with analgesic and antipyretic effects that work by blocking prostaglandin production. Esomeprazole is a proton pump inhibitor that inhibits gastric acid secretion by targeting the H+/K+ ATPase in gastric cells, leading to reduced gastric acidity. It selectively acts on the proton pump, blocking the final stage of acid generation.

✔️ Dosage & Administration of Naproxen Plus Tablet

Before using Naprosyn ES 500mg DR Tablet 10's, carefully consider the potential benefits and risks, as well as other treatment options. Use the lowest effective dose for the shortest duration that aligns with the individual patient's treatment goals. If a lower dose of Esomeprazole (less than 40 mg total daily dose) is more appropriate, consider alternative treatments.

Dosage for different conditions:

Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis in adults: Take one tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole.

Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age and Older:

  • Weight greater than 50 kg: Take one tablet twice daily of 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole.
  • Weight 38 kg to less than 50 kg: Take one tablet twice daily of 375 mg naproxen/20 mg of esomeprazole.

Important instructions:

  • Do not split, chew, crush, or dissolve the tablet.
  • Take the tablet at least 30 minutes before meals.
✔️ Interaction

Naproxen Plus Tablet may interact with several drugs and should be used with caution in certain medical conditions:

Drug-Drug Interactions:

  • Interaction with anti-inflammatory medicines (e.g. aspirin, ibuprofen)
  • Interaction with blood thinners (e.g. warfarin, rivaroxaban)
  • Interaction with steroids (e.g. prednisolone)
  • Interaction with diuretic medicines (e.g. furosemide)
  • Interaction with heart and high blood pressure-lowering medicines (e.g. propranolol, enalapril, losartan, candesartan)
  • Interaction with antidepressants (e.g. citalopram)
  • Interaction with medicine used to treat rheumatoid arthritis (e.g. methotrexate)

Drug-Food Interactions:

  • Interaction with alcohol: Avoid alcohol intake while taking Naproxen Plus Tabletas it may increase the risk of stomach bleeding and cause drowsiness and dizziness.

Drug-Disease Interactions:

  • People with diabetes, stomach ulcers, gastrointestinal bleeding, asthma, kidney, liver, or heart problems, and autoimmune conditions like systemic lupus erythematosus, colitis, or Crohn’s disease should consult a doctor before taking Naproxen Plus Tablet.
✔️ Contraindications

Naproxen Plus Tablet is contraindicated in the following situations:

  • Hypersensitivity to any of the ingredients of the product.
  • Patients who have developed asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
  • Treatment of intraoperative pain during coronary artery bypass grafting (CABG).
✔️ Pregnancy & Lactation

Use of Naproxen Plus Tablet should be avoided during pregnancy and breastfeeding unless the benefit of the other tablet outweighs the possible risk to the fetus.

✔️ Precautions & Warnings
  • Avoid Naproxen Plus Tablet if you are allergic to it.
  • Long-term use of NSAIDs like naproxen may increase the risk of heart attack, stroke, and stomach ulcers.
  • Higher risk of ulcers if you have a history of ulcers, bleeding disorders, alcoholism, or multiple diseases.
  • Elderly patients are at greater risk for gastrointestinal bleeding problems, so their dose should be limited.
  • Not recommended for pregnant women, especially in the third trimester, as it may harm the baby. Consult a doctor if pregnant or breastfeeding.
  • Not recommended for children unless prescribed by a doctor.
  • Do not take other NSAIDs for pain relief along with Naproxen Plus Tablet unless prescribed.
  • Prolonged use of esomeprazole may affect bone health, so taking Vitamin D and calcium might be advised by the doctor.
  • Avoid alcohol with Naproxen Plus Tablet to reduce the risk of stomach bleeding or ulcer.
✔️ Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
Product Availability & Pricing Notice Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.

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