Motigut 10mg Tablet

Uses of Motigut 10

• Indigestion
• Nausea
• Vomiting

Side effects of Motigut 10

• Extrapyramidal effects
• Drowsiness
• Galactorrhea,
• Gynecomastia
• Constipation or diarrhea
• Lethargy, loss of libido
• Skin rash, and itching
• Convulsions
• Arrhythmias and cardiac arrest,
• Dysrhythmias in people with cardiovascular disease or hypokalemia
• and people receiving chemotherapy for cancer are all potentially fatal. seizures and hypertensive crises in pheochromocytoma patients.

Quick Suggestions:

• Motigut 10 aids in the relief of nausea, vomiting, and indigestion.
• It should be taken before meals, according to your doctor's instructions.
• In adults and adolescents 12 years of age and older with a body weight of 35kg or more, domperidone should be used at the lowest effective dose.
•  
• It can make you dizzy and sleepy. Do not drive or engage in any activity that requires mental focus until you have determined how it affects you.
• When taking Motigut 10, avoid drinking alcohol as it may cause excessive drowsiness.
• As a side effect, dry mouth is possible. Frequent mouth rinses, good oral hygiene, increased water consumption, and sugarless candy may be beneficial.
• Inform your doctor if you develop watery diarrhea, a fever, or persistent stomach pain.
• Contact your doctor if you have palpitations, difficulty breathing, or loss of consciousness while taking this medication. Domperidone treatment should be discontinued. Without consulting your doctor, do not take it for more than 7 days.

Indications

Motigut is an antiemetic and prokinetic medication. It belongs to a class of drugs known as dopamine antagonists. It is used to treat stomach problems such as nausea and vomiting, as well as stomach pain and discomfort caused by decreased stomach and upper gastrointestinal (GI) tract movement. It is also used to increase the supply of breast milk.

Pharmacology

Motigut may be a dopamine antagonist that primarily targets the stomach's and the Chemoreceptor rigger Zone's (CTZ) dopamine receptors. Its gastroprokinetic function is dependent on the dopamine receptors it blocks, which affect gastrointestinal tract motility. Domperidone has a negligible effect on the dopaminergic receptors in the brain because of its inability to cross the blood-brain barrier; as a result, it has no psychotropic or neurologic adverse effects. Domperidone improves antral and duodenal peristalsis, restores normal upper gastrointestinal tract motility and tone, and inhibits pylorus withdrawal. It also promotes gastric purge. Domperidone also increases esophageal peristalsis and decreases the weight of the esophageal sphincter, preventing the release of gastric contents.

Dosage & Administration of Motigut 10

Motigut should be consumed 15 to 30 minutes after supper and, if necessary, just before retiring.

The regular suggested verbal dosage of Domperidone is as follows: 

• Adults: 10–20 mg every 6–8 hours throughout the day (1-2 tablets or 10–20 ml solution). The highest dosage of Domperidone is 80 mg per day.
• Children: every 6 to 8 hours, 2-4 ml suspension/10 kg body weight or 0.4 to 0.8 ml pediatric drops/10 kg body weight.

In Dyspeptic symptoms: 

• Adults: 10–20 mg every 6–8 hours (1-2 tablets or 10–20 ml solution).
• Children: every 6 to 8 hours, 0.2 to 0.4 mg/kg (2-4 ml suspension/10 kg or 0.4 to 0.8 ml pediatric drops/10 kg) body weight.

In intense and sub-acute conditions (primarily in intense sickness and vomiting): 

• Adults: twice daily, every 6 to 8 hours, 20 mg (2 tablets or 20 ml suspension).
• Children: every 6 to 8 hours, 0.2 to 0.4 mg/kg (2-4 ml suspension/10 kg or 0.4 to 0.8 ml pediatric drops/10 kg) body weight. The most extreme treatment term for severe nausea and vomiting is 12 weeks.

Renal Dose

• Mild to moderate kidney impairment: No dosage adjustment needed. Severe: With prolonged treatment, reduce dosing to 1-2 times daily.

How to use Motigut 10

• Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole.
• Do not chew, crush or break it.
• Motigut 10 is to be taken empty stomach.

How Motigut 10 works

Motigut 10 is a prokinetic. It works on the region in the brain that controls vomiting. It also acts on the upper digestive tract to increase the movement of the stomach and intestines, allowing food to move more easily through the stomach.

What if you forget to take Motigut 10?

If you miss a dose of Motigut 10, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Interaction

The risk of bromocriptine's hypoprolactemic effects may be reduced by Motigut. Antimuscarinics and opioid analgesics may counteract Motigut's activity on Gl work. When domperidone is used in conjunction with MAO (monoamine oxidase) inhibitors, caution should be taken.

Contraindications

Neonatal patients and those with documented high sensitivity to this sedative should not use Motigut. When gastrointestinal stimulation can be dangerous, such as when it results in gastrointestinal hemorrhage, mechanical obstruction, or puncturing, domperidone shouldn't be taken. Too dangerous for people with prolactin-releasing pituitary tumors (prolactinoma).

Pregnancy & Lactation

The security of domperidone has not been demonstrated and it is in this manner not suggested amid pregnancy. The creature thinks about has not illustrated the teratogenic impact within the embryo. Motigut may accelerate galactorrhea and move forward post-natal lactation. It is emitted in breast drain but in exceptionally little amounts deficiently to be considered destructive.

Precautions & Warnings

• Motigut should be used with extreme caution when treating children because extrapyramidal reactions may be more likely in young children due to an incompletely formed blood-brain barrier.
• Since domperidone is exceedingly metabolized in the liver, it ought to be utilized with caution in understanding hepatic disability.

Storage Conditions

Store below 30°C, Secured from light & dampness. Keep out of children's reach.