Utifin SR 100mg Capsule

✔️ Composition

50 mg Capsule

Each capsule contains Nitrofurantoin (as macrocrystal) USP 50 mg.

100 mg Capsule

Each capsule contains Nitrofurantoin (as macrocrystal) USP 100 mg.

Oral Suspension

Each 5 mL suspension contains Nitrofurantoin Monohydrate USP equivalent to Nitrofurantoin 25 mg.

✔️ Nitrofurantoin Capsule – Adults

Acute uncomplicated UTI:

• 50 mg four times daily for 7 days.

Long-term suppression:

• 50–100 mg once daily.

Prophylaxis:

• 50 mg four times daily during the procedure and for 3 days afterward, when prescribed for an appropriate procedure.

✔️ Interaction

• Magnesium trisilicate-containing antacids: May reduce the absorption of nitrofurantoin and decrease its effectiveness. Avoid concomitant use unless advised by a healthcare professional.
• Probenecid and sulfinpyrazone: May inhibit renal tubular secretion of nitrofurantoin, potentially increasing systemic exposure and reducing urinary concentrations. Concomitant use should be discussed with the prescribing physician.

Inform your doctor or pharmacist about all medicines, supplements, and antacids you are taking.

✔️ Utifin SR should not be used in patients with:

• Anuria.
• Oliguria.
• Significant renal impairment.
• Known hypersensitivity to nitrofurantoin or any component of the formulation.
• Infants below 1 month of age.
• Pregnancy at 38–42 weeks, during labour, or during delivery, because of the risk of haemolytic anaemia in the newborn.

✔️ Interaction

• Magnesium trisilicate-containing antacids: May reduce the absorption of nitrofurantoin and decrease its effectiveness. Avoid concomitant use unless advised by a healthcare professional.
• Probenecid and sulfinpyrazone: May inhibit renal tubular secretion of nitrofurantoin, potentially increasing systemic exposure and reducing urinary concentrations. Concomitant use should be discussed with the prescribing physician.

✔️ Side Effects

• Nausea
• Headache
• Flatulence
• Diarrhoea
• Dyspepsia
• Abdominal pain
• Constipation
• Vomiting
• Dizziness
• Drowsiness

✔️ Pregnancy & Lactation

Nitrofurantoin should be used during pregnancy only when clearly indicated and prescribed by a healthcare professional.

It is generally avoided near term, particularly from 38 weeks through labour and delivery, because of the potential risk of haemolytic anaemia in newborns with immature red blood cell enzyme systems.

Small amounts of nitrofurantoin can pass into breast milk. Use during breastfeeding should be discussed with a healthcare professional, particularly when nursing an infant younger than 1 month or an infant with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

✔️ Precautions & Warnings

• Discontinue nitrofurantoin and seek medical attention if symptoms of acute, subacute, or chronic pulmonary reactions occur, such as persistent cough, shortness of breath, fever, or chest discomfort.
• Use with caution in patients with renal impairment, as reduced kidney function may decrease urinary drug concentrations and increase the risk of adverse effects.
• Long-term therapy may require monitoring for pulmonary, hepatic, neurological, and other adverse reactions.
• Avoid magnesium trisilicate-containing antacids while taking nitrofurantoin unless specifically advised by a healthcare professional.
• Nitrofurantoin is intended primarily for urinary tract infections and should not be used to treat systemic infections such as bloodstream infections.

✔️ Storage:

• Store below 30°C.
• Protect from light.
• Keep out of reach of children.
• Store the oral suspension according to the specific instructions provided on the product packaging.