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- Xytrex 10 works well in schizophrenia and bipolar disorder.
- It is less likely to cause heart and movement problems compared to other similar medicines.
- It may take 4 to 6 weeks to see the full effects on thoughts and mood. Keep taking it as prescribed.
- Use caution while driving or doing anything that requires concentration, as Xytrex 10 can cause dizziness and sleepiness.
- It may increase your weight, blood sugar, and cholesterol. Eat healthy, exercise regularly, and monitor your blood levels regularly.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Do not stop taking Xytrex 10 without talking to your doctor first, as it may cause worsening of symptoms.
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✅ Description:
Xytrex is prescribed for:
- Schizophrenia and related psychoses – particularly when positive symptoms (delusions, hallucinations, disordered thinking, hostility, suspiciousness) and/or negative symptoms (flattened affect, emotional/social withdrawal, limited speech) are significant.
- Bipolar disorder – treatment of acute manic or mixed episodes, with or without psychotic features, including cases with rapid cycling.
Use only under the guidance of a registered physician.
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✔️ Drug Interactions
- May reduce the effects of levodopa and dopamine agonists
- Drugs inducing CYP1A2 or glucuronyl transferase (e.g., omeprazole, rifampicin) may increase clearance of Xytrex
- CYP1A2 inhibitors may reduce Xytrex elimination
- Carbamazepine may increase clearance
- Activated charcoal reduces oral bioavailability by 50–60%
- Use caution with centrally acting drugs and alcohol
✔️ Side Effects
Very common:
- Somnolence (sleepiness)
- Weight gain
Other possible effects:
- Increased appetite
- Elevated glucose and triglycerides
- Dizziness
- Akathisia (restlessness)
- Parkinsonian symptoms or dyskinesia
- Orthostatic hypotension
- Mild anticholinergic effects: constipation, dry mouth
- Asthenia (weakness), edema, photosensitivity
✔️ Pharmacology
Olanzapine is an atypical antipsychotic that interacts with:
Serotonin receptors: 5HT2A/2C, 5HT3, 5HT6
Dopamine receptors: D1–D5
Cholinergic muscarinic receptors: M1–M5
α1 adrenergic and histamine H1 receptors
Mechanism of Action:
The precise mechanism is not fully understood. It is believed that Xytrex’s effects in schizophrenia are due to a combination of dopamine and serotonin 5-HT2 receptor antagonism.
Pharmacokinetics:
Well absorbed orally, peak plasma levels in 5–8 hours
Food does not affect absorption
Not mutagenic, clastogenic, or carcinogenic
- Children (<18 years): Not studied
- Elderly (>65 years): Start at 5 mg/day
- Hepatic or renal impairment: Start at 5 mg/day
✔️ Administration
Can be taken with or without food
Dose tapering is recommended when discontinuing treatment
✔️ Dosage
Schizophrenia or bipolar disorder (combination therapy):
- Initial: 5–10 mg once daily
- Adjust according to clinical response, range: 5–20 mg/day
- Doses above 10 mg/day should follow reassessment
- Maximum: 20 mg/day
Monotherapy for mania:
- Initial: 15 mg once daily
- Adjust according to response, range: 5–20 mg/day
- Doses above 15 mg/day require reassessment
- Maximum: 20 mg/day
Use only under physician supervision.
✔️ Contraindications:
Hypersensitivity to olanzapine or any component of the product
Known risk for narrow-angle glaucoma
✔️ Pregnancy & Lactation
- Use during pregnancy only if the benefits outweigh the risks
- Notify your physician if pregnant or planning a pregnancy
- Breastfeeding is not recommended while taking Xytrex
✔️ Use cautiously in patients with:
- Seizure history or risk of seizures
- Low leukocyte/neutrophil counts or drug-induced bone marrow suppression
- Hypereosinophilic conditions
- Liver impairment or hepatotoxic drug use
- Drugs that prolong QT interval
- Elderly patients require caution
- Avoid operating machinery or driving if dizziness occurs
✔️ Storage:
Store below 30°C, away from light and moisture
Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
