Supadopa TR 61.25mg+245mg Capsule

✔️ Uses of Supadopa TR 61.25mg+245mg Capsule

• Parkinson disease

✔️ Dosage & Administration of Supadopa TR 61.25mg+245mg Capsule

For Patients New to Levodopa Treatment:

• The initial recommended dose of Supadopa TR for individuals who have not previously used levodopa is 95 mg, taken three times daily for the first three days.
• From the fourth day, the dosage may be increased to 145 mg three times daily, based on the patient’s response and tolerance.
• The maximum recommended dose is 390 mg per dose, taken three times daily, with adjustments up to five doses per day if necessary.
• The maximum daily dosage should not exceed 2,450 mg.

Transitioning from Immediate-Release Carbidopa-Levodopa to Supadopa TR:

• The dosages of different carbidopa-levodopa formulations are not interchangeable on a 1:1 ratio.
• When switching from immediate-release formulations to Supadopa TR, the total daily levodopa intake should be recalculated, with dosages adjusted accordingly.
• If a patient is also taking a catechol-O-methyl transferase (COMT) inhibitor (e.g., entacapone), an increased initial daily levodopa dose may be necessary.

Conversion Guidelines from Immediate-Release Levodopa-Carbidopa to Supadopa TR:

This medication should only be taken as directed by a registered physician.

✔️ Side Effects of Supadopa TR 61.25mg+245mg Capsule

Common Side Effects:

• Nausea
• Vomiting
• Dry mouth
• Constipation
• Dizziness
• Drowsiness
• Headache
• Unusual dreams
• Anxiety
• Insomnia
• Involuntary movements (dyskinesia)
• Low blood pressure upon standing (orthostatic hypotension)

Rare but Serious Side Effects:

• Edema
• Hallucinations
• Increased trembling
• Memory loss
• Restlessness
• Vivid dreams
• Alopecia (hair loss)
• Increased sweating or skin reactions
• Stomach pain, diarrhea, or difficulty swallowing
• Muscle cramps or spasms
• Urinary retention or dark-colored urine
• Blurred or double vision
• Severe postural hypotension, especially in elderly patients

✔️ Drug Interactions

• Iron supplements and dopamine D2 antagonists (such as metoclopramide) may reduce the effectiveness of Supadopa TR.
• Monoamine oxidase inhibitors (MAOIs): This medication should not be used alongside nonselective MAOIs (e.g., phenelzine, tranylcypromine) or within two weeks of discontinuing such drugs, as it may cause severe hypertension.

✔️ Supadopa TR should not be used in patients with:

• Current or recent use (within 2 weeks) of nonselective MAO inhibitors
• Lactation
• Narrow-angle glaucoma
• Melanoma
• Severe psychiatric disorders, such as psychosis
• Severely decompensated endocrine conditions

✔️ Use in Pregnancy & Lactation

• Pregnancy: Supadopa TR should be used during pregnancy only if necessary, as animal studies have indicated potential harm to the developing fetus. The prescribing doctor should carefully assess the risks and benefits before recommending this medication.
• Breastfeeding: The medication is likely safe during lactation, though levodopa may reduce milk production. If lactation is affected, milk supply typically returns to normal upon discontinuation of the drug.

✔️ Precautions & Warnings

• Alcohol consumption is unsafe with Supadopa TR 245.
• Driving & Operating Machinery: The medication may cause dizziness, drowsiness, or blurred vision, impairing the ability to drive.
• Renal Impairment: Likely safe, but consultation with a doctor is advised.
• Liver Impairment: Use with caution; dosage adjustment may be required.
• Risk of Sleep Attacks & Drowsiness: Some patients may experience sudden sleep episodes during daily activities.
• Psychiatric Effects: Can cause hallucinations, confusion, or compulsive behaviors such as gambling or excessive spending.
• Withdrawal Risks: Abrupt discontinuation may result in fever, rigidity, confusion, and autonomic instability.

✔️ Special Population Considerations

• Pediatric Use: Safety and efficacy have not been established in children.
• Elderly Patients: More susceptible to orthostatic hypotension and other adverse effects. Regular monitoring of kidney and liver function is recommended.

✔️ Storage Instructions

• Keep in a cool and dry place away from direct light and moisture.
• Ensure the medication is out of reach of children.