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Perkirol 2mg Tablet | 10's
Perkirol is a dopamine agonist indicated for:
- Idiopathic Parkinson’s disease – to relieve symptoms and improve motor function.
- Moderate-to-severe primary Restless Legs Syndrome (RLS) – to reduce discomfort and improve sleep.
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বাহিরে
✅ Description:
Ropinirole is a non-ergoline dopamine agonist with its highest affinity at D3 receptors, located in the limbic system, which may account for some neuropsychiatric effects.
- In Parkinson’s disease, its action is thought to result from selective stimulation of dopamine D2 receptors within the caudate-putamen system, which regulates movement.
- In RLS, while the exact mechanism is unclear, it is believed to act through dopamine receptor stimulation.
Ropinirole shows negligible activity at peripheral α2-adrenoceptors, 5HT-1 receptors, benzodiazepine receptors, or GABA receptors, and no affinity for D1-like receptors.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Therapeutic Class
Antiparkinson drugs (dopamine agonists)
✔️ Dosage & Administration
For Parkinson’s Disease (Adults):
- Initial dose: 0.25 mg three times daily.
- Titration: Adjust weekly based on patient response and tolerance.
- Maximum dose: 24 mg/day (8 mg three times daily).
Titration Schedule:
- Week 1: 0.25 mg TID (0.75 mg/day)
- Week 2: 0.5 mg TID (1.5 mg/day)
- Week 3: 0.75 mg TID (2.25 mg/day)
- Week 4: 1 mg TID (3 mg/day)
Further titration as needed up to max dose.
For Restless Legs Syndrome (Adults):
- Starting dose: 0.25 mg once daily, 1–3 hours before bedtime.
- After 2 days → may increase to 0.5 mg once daily.
- At the end of week 1 → 1 mg once daily.
Further titration based on response, up to a maximum of 4 mg daily.
Suggested Titration (if needed):
- Days 1–2: 0.25 mg once daily
- Days 3–7: 0.5 mg once daily
- Week 2: 1 mg once daily
- Week 3: 1.5 mg once daily
- Week 4: 2 mg once daily
- Week 5: 2.5 mg once daily
- Week 6: 3 mg once daily
- Week 7: 4 mg once daily
✔️ Side Effects
Commonly reported adverse reactions include:
- Neurological: fainting, drowsiness, dizziness, confusion, hallucinations, uncontrolled, sudden movements
- Gastrointestinal: nausea, vomiting, abdominal discomfort, upset stomach
- General: fatigue, headache, increased sweating
- Other: leg swelling, orthostatic hypotension
✔️ Drug Interactions
Dopamine antagonists (e.g., neuroleptics such as phenothiazines, butyrophenones, thioxanthenes, or metoclopramide) may reduce the therapeutic effect of Perkirol.
✔️ Contraindications:
Known hypersensitivity to Ropinirole or any component of the formulation.
✔️ Precautions & Warnings
- Pregnancy Category C – use only if potential benefits outweigh the risks, as safety in pregnancy is not established.
- May inhibit prolactin secretion, potentially reducing lactation.
- Risk of sudden sleep episodes during daily activities.
- May impair blood pressure regulation → risk of orthostatic hypotension.
- Caution in patients with cardiovascular risk or CNS side effects.
✔️ Storage:
Store below 25°C, protected from light and moisture.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
