HexPark 5mg Tablet 1 Strip

✔️ Uses of Hexpark 2

• Parkinson disease

✔️ Dosage and Administration

Dosage should be personalized based on the patient’s condition, age, and response to treatment. It is crucial to start with a low dose and increase gradually, especially in individuals over 60 years of ages

✔️ Quick Suggestions:

• HexPark can be taken before or after meals.
• If a patient experiences excessive salivation, taking the tablet after meals is preferable.
• If the medication causes dry mouth, it may be better to take it before meals, unless it induces nausea.
• If taken after meals, thirst-related discomfort can be alleviated with chewing gum, mint candies, or water.
• Abruptly stopping the medication may cause severe worsening of Parkinson’s symptoms or lead to Neuroleptic Malignant Syndrome (NMS), a potentially fatal reaction.

✔️ Potential Side Effects

🔹 Common Side Effects (30–50% of patients may experience these):

• Dry mouth
• Blurred vision
• Dizziness
• Mild nausea
• Nervousness

🔹 Less Common but Serious Side Effects:

• Severe dry mouth → Can cause suppurative parotitis (salivary gland infection).
• Skin rashes
• Gastrointestinal issues (e.g., paralytic ileus, colon dilation).
• Psychiatric effects (delusions, hallucinations, paranoia).
• Cognitive impairment (confusion, memory loss).
• Cardiac effects (tachycardia, bradycardia, arrhythmias).
• Urinary hesitancy or retention.
• Increased intraocular pressure (glaucoma risk).

Withdrawal symptoms → Abrupt discontinuation can lead to Neuroleptic Malignant Syndrome (NMS).

✔️ Overdose Management

🚨 Symptoms of Overdose:

• Extreme dry mouth, dilated pupils, facial flushing
• Confusion, hallucinations, paranoia, seizures
• Elevated heart rate, respiratory distress, potential coma

🛑 Emergency Treatment:

• Gastric lavage (stomach pumping)
• Supportive care (oxygen, IV fluids, respiratory assistance)
• Avoid phenothiazines (can worsen toxicity)
• Administer diazepam or short-acting barbiturates for severe agitation

✔️ Dosage for Different Conditions

✅ Idiopathic Parkinsonism:

• Start with 1 mg on the first day.
• Increase by 2 mg every 3–5 days until reaching 6–10 mg per day.
• Some patients, particularly those with postencephalitic Parkinsonism, may need a higher dose of 12–15 mg daily.

✅ Drug-Induced Parkinsonism (Extrapyramidal Reactions):

• Dosage varies between 5–15 mg daily, depending on symptom severity.
• In some cases, symptoms can be controlled with as little as 1 mg per day.
• If needed, the dose can be gradually increased.

In some cases, reducing the dosage of the causative CNS drug (e.g., tranquilizers) while introducing HexPark can enhance symptom control.

• After a few days of stabilization, the HexPark dose may be gradually lowered.

✅ Combination Therapy with Levodopa:

• When used with levodopa, the dose of both medications may require adjustment.
• A daily Trihexyphenidyl dose of 3–6 mg, divided into multiple doses, is typically sufficient.

✅ Concomitant Use with Other Anticholinergics:

• Trihexyphenidyl can partially or fully replace other parasympathetic inhibitors.
• A gradual substitution method is often followed to transition from one drug to another.

✅ Dividing the Daily Dose:

• The total daily dose is best divided into three doses, taken with meals.
• For doses exceeding 10 mg daily, the dose should be split into four doses—three with meals and one at bedtime.

✅ Use in Children:

• Not recommended due to a lack of sufficient safety and efficacy data.

Reminder: Always follow the prescribed dosage and consult your doctor before making any changes.

✔️ Drug Interactions

HexPark may interact with various substances, potentially increasing side effects or altering drug efficacy:

🚫 CNS Depressants (e.g., alcohol, opiates, barbiturates, cannabinoids) → May enhance sedative effects and lead to misuse potential.
🚫 Monoamine Oxidase Inhibitors (MAOIs) & Tricyclic Antidepressants → May increase anticholinergic effects.
🚫 Neuroleptics (antipsychotics) → May elevate the risk of tardive dyskinesia.
🚫 Levodopa → Dose adjustments may be necessary to prevent excessive involuntary movements.

✔️ Contraindications (Who Should Avoid HexPark?)

❌ Patients allergic to Trihexyphenidyl.
❌ Individuals with narrow-angle glaucoma (risk of blindness reported)

✔️ ⚠️ Pediatric patients may experience additional side effects, including:

• Hyperactivity
• Psychosis
• Forgetfulness
• Weight loss
• Restlessness
• Sleep disturbances

✔️ Warnings and Precautions

• Monitor intraocular pressure before and during treatment (risk of glaucoma).
• Avoid prolonged heat exposure (risk of severe dehydration and hyperthermia).
• If experiencing blurred vision, check for narrow-angle glaucoma.

Abrupt withdrawal can lead to severe complications (e.g., Neuroleptic Malignant Syndrome).

✔️ Use in Pregnancy and Lactation

🔹 Pregnancy:

Not enough data on safety. Should only be used if benefits outweigh risks.

🔹 Breastfeeding:

Unknown if excreted in breast milk, so use it with caution.

May reduce milk production.

✔️ Storage Instructions

• Store at ≤30°C in a dry, dark place.
• Keep away from children.