Inoten 20mg Tablet

Uses of Inoten 20mg Tablet

Pain relief and management of musculoskeletal and joint disorders.

How does Inoten 20mg Tablet work?

It works by inhibiting chemical mediators that cause pain and inflammation.

Side Effects of Inoten 20mg Tablet

• Generally well-tolerated.
• Common: Gastrointestinal discomfort, dyspepsia, nausea, dizziness, headache.
• Less common: Constipation, diarrhea, stomatitis, fatigue, skin reactions, increased liver enzyme activity.
• Rare: Gastrointestinal perforation, visual disturbances, Stevens-Johnson syndrome, blood disorders, hypersensitivity reactions, elevated blood pressure.

Quick Suggestions:

• Take Inoten 20mg Tablet exactly as prescribed by the doctor. Do not take in larger amounts than advised/prescribed.
• Consult the doctor if you experience any undesirable side effects.
• Do not stop the use of this medicine without consulting your doctor.

Indications:

Symptomatic treatment of painful inflammatory and degenerative musculoskeletal disorders.

• Rheumatoid arthritis
• Osteoarthritis
• Arthrosis
• Ankylosing spondylitis
• Extra-articular disorders (tendinitis, bursitis, periarthritis, strains, sprains)
• Acute gout

Pharmacology

• Non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties.
• Inhibits prostaglandin biosynthesis, and acts as a scavenger for active oxygen at the site of inflammation.
• Strong in-vitro inhibitor of human metalloproteinases, explaining its therapeutic benefits in inflammatory and degenerative musculoskeletal disorders.
• No mutagenic, carcinogenic, or teratogenic effects were observed in animals.

Dosage & Administration:

• Standard dosage: 20 mg once daily at the same time of day for all indications (except acute gout).
• Acute gout: 40 mg once daily for two days followed by 20 mg once daily for five days.
• Chronic disorders: Early therapeutic effect, with a progressive increase in response over time. Daily doses >20 mg in chronic disorders should be avoided.
• Reduction to a daily oral dose of 10 mg may be considered for maintenance in long-term treatment.

Interaction

• Salicylates may displace tenoxicam from protein-binding sites, increasing the risk of gastrointestinal reactions.
• Caution with concurrent use of NSAIDs and methotrexate.
• No clinically relevant interaction was found with gold, penicillamine, or probenecid.
• Tenoxicam may decrease the renal clearance of lithium, requiring close monitoring of lithium levels.

Contraindications

• Hypersensitivity to the drug.
• Hypersensitivity to salicylates or other NSAIDs causing asthma, rhinitis, or urticaria.
• History of upper gastrointestinal tract diseases such as gastritis, gastric, and duodenal ulcers.

Pregnancy & Lactation

• Avoid use during the third trimester of pregnancy.
• The small amount excreted in breast milk; no evidence of adverse reactions, but caution is advised.

Precaution & Warnings:

• Caution in patients with asthma, hypertension, heart failure, gastrointestinal diseases, fluid retention, and edema.
• Monitor patients with renal, hepatic, and cardiac conditions.
• Inhibition of platelet aggregation may affect hemostasis.
• Not recommended for patients undergoing major surgery.
• Elderly patients should use the lowest effective dose.

Storage Conditions

Store below 30°C, protect from light and moisture and keep out of children's reach.