Indomet 100mg Suppository

Uses of Indomet 100mg Suppository

• Osteoarthritis
• Rheumatoid Arthritis
• Ankylosing Spondylitis
• Bursitis
• Tendinitis
• Acute Gout

How does Indomet 100mg Suppository work?

Indomet 100mg Suppository contains 'Indomethacin' that works by blocking the effect of chemical messengers known as cyclo-oxygenase (COX) enzymes. By blocking the effect of COX enzymes, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Side Effects of Indomet 100mg Suppository

• Mild headache
• Ringing or buzzing or other unexplained noise in the ears
• Difficulty having a bowel movement
• Discouragement, feeling sad or empty
• A general feeling of discomfort or illness
• Hearing loss
• Irritability
• Loss of interest or pleasure
• Sleepiness, trouble concentrating
• Anxiety
• Bloated or full feeling
• Excess air or gas in the stomach or intestines
• The feeling of constant movement of self or surroundings
• Involuntary muscle movements
• Light-headedness
• Sensation of spinning
• Tiredness
• Trouble sleeping
• Trouble with speaking

Quick Suggestions:

• Regular physical activity, such as walking or swimming for 20-30 minutes, can help strengthen muscles and alleviate joint stiffness. Engaging in yoga can improve joint flexibility and assist with pain management. It is important to maintain a healthy weight through regular low-impact exercises and a balanced diet. Sufficient sleep is essential as it allows muscles to rest and reduces inflammation and swelling.
• Heat or cold therapy can be applied to the joints for 15-20 minutes using a hot or cold compress on a regular basis. Finding ways to de-stress, such as meditation, reading, taking warm baths, or listening to soothing music, can also be beneficial. Indomet Suppository has been prescribed to you to relieve pain and inflammation. It is advisable to take it with food or milk to prevent stomach upset.
• Follow the prescribed dose and duration provided by your doctor, as long-term use of the medication can lead to serious complications like stomach bleeding and kidney problems. Be aware that Indomet Suppository may cause dizziness, drowsiness, or visual disturbances, so use caution when driving or performing tasks that require concentration.
• Avoid consuming alcohol while taking Indomet Suppository, as it can increase drowsiness and raise the risk of stomach problems. Inform your doctor if you have a history of heart disease or stroke. If you are using this medication for long-term treatment, your doctor may monitor your kidney function, liver function, and blood components regularly.
• Additional methods such as acupuncture, massage, and physical therapy may also provide relief. Including foods rich in antioxidants in your diet, such as berries, spinach, kidney beans, and dark chocolate, can be beneficial. Foods containing flavonoids, including soy, berries, broccoli, grapes, and green tea, can help reduce inflammation. Finally, it is important to avoid smoking and alcohol consumption for overall health and well-being.

Indication

Indomet 100mg Suppository is used to reduce pain caused by conditions such as:

• Moderate to severe rheumatoid arthritis including acute flares of chronic disease
• Moderate to severe ankylosing spondylitis and osteoarthritis
• Shoulder pain (bursitis and/or tendinitis)
• Acute gouty arthritis (severe pain, redness, and tenderness in joints)

Pharmacology

Indometacin, which is an indole acetic acid derivative, exhibits anti-inflammatory, analgesic, and antipyretic properties. It works by reversibly inhibiting the enzymes cyclooxygenase-1 and -2 (COX-1 and COX-2), thereby reducing the synthesis of prostaglandin precursors. By inhibiting these enzymes, indometacin helps alleviate inflammation, pain, and fever.

Dosage of Indomet 100mg Suppository

Here are the recommended doses for indometacin (indomethacin) in adults and children:

Adult Dose:

• Rectal Pain and inflammation associated with musculoskeletal and joint disorders: As a suppository, 100 mg is to be inserted at night and repeated in the morning if necessary.

Child Dose:

Indomet 100mg Suppository is not recommended for use in children aged below 14 years. Consult your doctor for advice.

Please note that these are general guidelines, and the specific dosage may vary based on the individual's condition and the prescribing doctor's instructions. It is important to follow the prescribed dose and consult with a healthcare professional for personalized dosage recommendations.

Administration of Indomet 100mg Suppository

1. Wash your hands before handling the suppository.
2. Remove the wrapper from the suppository before inserting it.
3. Lie down in a comfortable position, preferably on your side.
4. Gently insert the suppository into the rectum using your finger or an applicator provided, as directed by your doctor.
5. Push the suppository past the sphincter muscle into the rectum.
6. Once inserted, remain lying down for a few minutes to allow the suppository to dissolve.
7. Try to avoid having a bowel movement for at least an hour to allow the medication to be absorbed.
8. Follow the dose and duration prescribed by your doctor. Do not exceed the recommended dose unless instructed by your healthcare provider.
9. If you have any questions or concerns about the correct usage of Indomet 100mg Suppository, consult your doctor or pharmacist for clarification.

Remember, it is important to follow the instructions provided by your healthcare professional to ensure safe and effective use of the medication.

Interaction

Drug-Drug Interactions:

1. Blood thinners (warfarin, aspirin): Indomet 100mg Suppository may increase the risk of bleeding when used concomitantly with blood thinners. Close monitoring of blood clotting parameters is recommended.
2. Diuretics (furosemide): Indomet 100mg Suppository may reduce the diuretic effect of furosemide. Your doctor may need to adjust the dose of diuretic if used together.
3. Cardiac glycoside (digoxin): Indomet 100mg Suppository may increase the levels of digoxin in the blood. Your doctor may need to monitor your digoxin levels closely and adjust the dose if necessary.

Drug-Food Interactions: No interactions have been reported between Indomet 100mg Suppository and food.

Drug-Disease Interactions:

1. Proctitis (inflammation of the rectal lining): Indomet 100mg Suppository should be used with caution in individuals with a history of proctitis, as it may worsen the condition.
2. Recent rectal bleeding: Indomet 100mg Suppository should be avoided in individuals with recent rectal bleeding.
3. Heart bypass surgery: Indomet 100mg Suppositories are not recommended before or after heart bypass surgery.

Contraindications

Indomethacin is contraindicated in patients with ulcers, gastritis, and active ulcerative colitis. These conditions involve inflammation and damage to the gastrointestinal tract, and the use of indomethacin can further aggravate these conditions and increase the risk of complications. Therefore, it is important to avoid using indomethacin in such patients.

Additionally, if a patient has a history of hypersensitivity or an allergic reaction to indomethacin or any other nonsteroidal anti-inflammatory drug (NSAID), the use of indomethacin is contraindicated. Hypersensitivity reactions can range from mild skin reactions to severe allergic reactions, including anaphylaxis, a life-threatening condition.

In patients with a history of ulcers, gastritis, active ulcerative colitis, or hypersensitivity to indomethacin or other NSAIDs, alternative treatment options should be considered. It is important to discuss your medical history and any known allergies with your healthcare provider before starting any new medication.

Pregnancy & Lactation

Pregnant women who are more than 32 weeks pregnant should avoid using indomethacin due to the risk of heart issues in the infant. Women with a history of ulcers, bleeding disorders, or kidney or liver disease should also avoid using indomethacin. It is important to consult with your doctor before taking any medication during pregnancy to ensure the safety of both the mother and the baby.

Precautions & Warnings

• Do not take Indomet 100mg Suppository 5's if you are allergic to Indomet 100mg Suppository 5's or any of its ingredients. It is important to inform your doctor about your allergies before starting any new medication.
• Inform your doctor if you are scheduled to undergo heart bypass surgery (CABG) or graft surgery, as the use of Indomet 100mg Suppository 5's may not be recommended in such cases. It is also important to inform your doctor if you have severe heart failure, a history of proctitis (inflammation of the rectal lining), or recent rectal bleeding, or if you have experienced bleeding problems such as bleeding from the stomach or bowels while taking any painkillers. Additionally, if you have liver or kidney problems, it is important to discuss this with your doctor before usingIndomet 100mg Suppository.
• Indomet 100mg Suppository 5's should not be taken during pregnancy or while breastfeeding unless prescribed by a healthcare professional. It is important to consult with your doctor before using any medication during pregnancy or while breastfeeding.
• Indomet 100mg Suppository 5's can cause dizziness, so it is important to assess your alertness before driving or operating machinery. It is advisable to avoid alcohol consumption while takingIndomet 100mg Suppository 5's as it can increase the risk of dizziness and may also increase the risk of stomach bleeding.
• If you experience stomach pain or notice any signs of bleeding in the intestine or stomach, such as blood in stools, while taking Indomet 100mg Suppository, you should stop taking the medication and consult your doctor immediately. These symptoms could indicate a serious condition and require prompt medical attention.

Storage Conditions

• Keep out of reach of children
• Store in a dry place below 30°C